Atypical presentation of Hand foot mouth disease (HFMD) caused by enterovirus serotype Coxsackievirus A6, in India
A 27-year-old male presented in the OPD of Naval Hospital in Port Blair, Andaman Islands, India, in 2011 with a history of low-grade fever associated with malaise and a pruritic skin rash. Case 2 – A 17-year-old male student reported to the OPD at Naval Hospital, Kochi Kerala, India, in August 2015....
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Sarajevo
2019-08-01
|
| Series: | Journal of Health Sciences |
| Subjects: | |
| Online Access: | https://www.jhsci.ba/ojs/index.php/jhsci/article/view/733 |
| _version_ | 1828430179632939008 |
|---|---|
| author | Muruganandam Nagarajan Itta Krishna Chaaithanya Rehnuma Parvez Surya Palani Anwesh Maile Madhuri Matta Paluru Vijayachari |
| author_facet | Muruganandam Nagarajan Itta Krishna Chaaithanya Rehnuma Parvez Surya Palani Anwesh Maile Madhuri Matta Paluru Vijayachari |
| author_sort | Muruganandam Nagarajan |
| collection | DOAJ |
| description | A 27-year-old male presented in the OPD of Naval Hospital in Port Blair, Andaman Islands, India, in 2011 with a history of low-grade fever associated with malaise and a pruritic skin rash. Case 2 – A 17-year-old male student reported to the OPD at Naval Hospital, Kochi Kerala, India, in August 2015. He presented with eruptions on both the palm and soles with a history of high-grade fever for the past 3–4 days. Clinically, both the cases were diagnosed as hand, foot, and mouth disease (HFMD). Both samples were tested against measles virus and varicella-zoster IgM antibodies by enzyme immunoassay and found negative. Stool sample (case 1) and lesion swab (case 2) were processed by enterovirus reverse transcription polymerase chain reaction and phylogenetic analysis, and both were positive for enterovirus human coxsackievirus A6 (CVA6) (untranslated region [UTR]). Phylogenetic analysis also confirmed that both the CVA6 etiology belonged to the genotype F. HFMD in adults often asymptomatic and very few patients get atypical symptoms. Clinical diagnosis is often troublesome to identify HFMD in such cases. An epidemiological surveillance/vigilance is essential to document these atypical cases in near future in developing countries like India. |
| first_indexed | 2024-12-10T17:44:49Z |
| format | Article |
| id | doaj.art-8b6ecfe40dd4457a97e2d58ac48fb918 |
| institution | Directory Open Access Journal |
| issn | 2232-7576 1986-8049 |
| language | English |
| last_indexed | 2024-12-10T17:44:49Z |
| publishDate | 2019-08-01 |
| publisher | University of Sarajevo |
| record_format | Article |
| series | Journal of Health Sciences |
| spelling | doaj.art-8b6ecfe40dd4457a97e2d58ac48fb9182022-12-22T01:39:16ZengUniversity of SarajevoJournal of Health Sciences2232-75761986-80492019-08-0110.17532/jhsci.2019.733Atypical presentation of Hand foot mouth disease (HFMD) caused by enterovirus serotype Coxsackievirus A6, in IndiaMuruganandam Nagarajan0Itta Krishna Chaaithanya 1Rehnuma Parvez2Surya Palani3Anwesh Maile4Madhuri Matta5Paluru Vijayachari6ICMR - Regional Medical Research Centre, Post Bag No.13, Port Blair 744 101, Andaman & Nicobar Islands, India.Health Research Unit, Department of Health Research, Government of India, Dahanu, District - Palghar 401 601, Maharashtra, IndiaICMR - Regional Medical Research Centre, Post Bag No.13, Port Blair 744 101, Andaman & Nicobar Islands, India.ICMR - Regional Medical Research Centre, Post Bag No.13, Port Blair 744 101, Andaman & Nicobar Islands, India.ICMR - Regional Medical Research Centre, Post Bag No.13, Port Blair 744 101, Andaman & Nicobar Islands, India.Commanding Officer, INHS Dhanvantri, Sanjivani, Kochi 682 001, Kerala IndiaICMR - Regional Medical Research Centre, Post Bag No.13, Port Blair 744 101, Andaman & Nicobar Islands,A 27-year-old male presented in the OPD of Naval Hospital in Port Blair, Andaman Islands, India, in 2011 with a history of low-grade fever associated with malaise and a pruritic skin rash. Case 2 – A 17-year-old male student reported to the OPD at Naval Hospital, Kochi Kerala, India, in August 2015. He presented with eruptions on both the palm and soles with a history of high-grade fever for the past 3–4 days. Clinically, both the cases were diagnosed as hand, foot, and mouth disease (HFMD). Both samples were tested against measles virus and varicella-zoster IgM antibodies by enzyme immunoassay and found negative. Stool sample (case 1) and lesion swab (case 2) were processed by enterovirus reverse transcription polymerase chain reaction and phylogenetic analysis, and both were positive for enterovirus human coxsackievirus A6 (CVA6) (untranslated region [UTR]). Phylogenetic analysis also confirmed that both the CVA6 etiology belonged to the genotype F. HFMD in adults often asymptomatic and very few patients get atypical symptoms. Clinical diagnosis is often troublesome to identify HFMD in such cases. An epidemiological surveillance/vigilance is essential to document these atypical cases in near future in developing countries like India.https://www.jhsci.ba/ojs/index.php/jhsci/article/view/733atypical hand, foot, and mouth diseaseenteroviruscoxsackievirus A6A6Andaman IslandsIndia |
| spellingShingle | Muruganandam Nagarajan Itta Krishna Chaaithanya Rehnuma Parvez Surya Palani Anwesh Maile Madhuri Matta Paluru Vijayachari Atypical presentation of Hand foot mouth disease (HFMD) caused by enterovirus serotype Coxsackievirus A6, in India Journal of Health Sciences atypical hand, foot, and mouth disease enterovirus coxsackievirus A6 A6 Andaman Islands India |
| title | Atypical presentation of Hand foot mouth disease (HFMD) caused by enterovirus serotype Coxsackievirus A6, in India |
| title_full | Atypical presentation of Hand foot mouth disease (HFMD) caused by enterovirus serotype Coxsackievirus A6, in India |
| title_fullStr | Atypical presentation of Hand foot mouth disease (HFMD) caused by enterovirus serotype Coxsackievirus A6, in India |
| title_full_unstemmed | Atypical presentation of Hand foot mouth disease (HFMD) caused by enterovirus serotype Coxsackievirus A6, in India |
| title_short | Atypical presentation of Hand foot mouth disease (HFMD) caused by enterovirus serotype Coxsackievirus A6, in India |
| title_sort | atypical presentation of hand foot mouth disease hfmd caused by enterovirus serotype coxsackievirus a6 in india |
| topic | atypical hand, foot, and mouth disease enterovirus coxsackievirus A6 A6 Andaman Islands India |
| url | https://www.jhsci.ba/ojs/index.php/jhsci/article/view/733 |
| work_keys_str_mv | AT muruganandamnagarajan atypicalpresentationofhandfootmouthdiseasehfmdcausedbyenterovirusserotypecoxsackievirusa6inindia AT ittakrishnachaaithanya atypicalpresentationofhandfootmouthdiseasehfmdcausedbyenterovirusserotypecoxsackievirusa6inindia AT rehnumaparvez atypicalpresentationofhandfootmouthdiseasehfmdcausedbyenterovirusserotypecoxsackievirusa6inindia AT suryapalani atypicalpresentationofhandfootmouthdiseasehfmdcausedbyenterovirusserotypecoxsackievirusa6inindia AT anweshmaile atypicalpresentationofhandfootmouthdiseasehfmdcausedbyenterovirusserotypecoxsackievirusa6inindia AT madhurimatta atypicalpresentationofhandfootmouthdiseasehfmdcausedbyenterovirusserotypecoxsackievirusa6inindia AT paluruvijayachari atypicalpresentationofhandfootmouthdiseasehfmdcausedbyenterovirusserotypecoxsackievirusa6inindia |