Radioactive Seed Localization for Nonpalpable Breast Lesions: Systematic Review and Meta-Analysis
Background: This study is a systematic review with meta-analysis comparing radioactive seed localization (RSL) versus radio-guided occult lesion localization (ROLL) and wire-guided localization (WGL) for patients with impalpable breast cancer undergoing breast-conserving surgery and evaluating effic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/4/441 |
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| author | Hortência H. J. Ferreira Carla Daruich de Souza Lorena Pozzo Martha S. Ribeiro Maria Elisa C. M. Rostelato |
| author_facet | Hortência H. J. Ferreira Carla Daruich de Souza Lorena Pozzo Martha S. Ribeiro Maria Elisa C. M. Rostelato |
| author_sort | Hortência H. J. Ferreira |
| collection | DOAJ |
| description | Background: This study is a systematic review with meta-analysis comparing radioactive seed localization (RSL) versus radio-guided occult lesion localization (ROLL) and wire-guided localization (WGL) for patients with impalpable breast cancer undergoing breast-conserving surgery and evaluating efficacy, safety, and logistical outcomes. The protocol is registered in PROSPERO with the number CRD42022299726. Methods: A search was conducted in the Embase, Lilacs, Pubmed, Scielo, Web of Science, and clinicaltrials.gov databases, in addition to a manual search in the reference list of relevant articles, for randomized clinical trials and cohort studies. Studies selected were submitted to their own data extraction forms and risk of bias analysis according to the ROB 2 and ROBINS 1 tools. A meta-analysis was performed, considering the random effect model, calculating the relative risk or the mean difference for dichotomous or continuous data, respectively. The quality of the evidence generated was analyzed by outcome according to the GRADE tool. Overall, 46 articles met the inclusion criteria and were included in this systematic review; of these, 4 studies compared RSL and ROLL with a population of 1550 women, and 43 compared RSL and WGL with a population of 19,820 women. Results: The results showed that RSL is a superior method to WGL in terms of surgical efficiency in the impalpable breast lesions’ intraoperative localization, and it is at least equivalent to ROLL. Regarding security, RSL obtained results equivalent to the already established technique, the WGL. In addition to presenting promising results, RSL has been proven to be superior to WGL and ROLL technologies. |
| first_indexed | 2024-03-07T22:35:37Z |
| format | Article |
| id | doaj.art-8b701cbda9fa4d17bb935ca5e07e5d66 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-07T22:35:37Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-8b701cbda9fa4d17bb935ca5e07e5d662024-02-23T15:13:55ZengMDPI AGDiagnostics2075-44182024-02-0114444110.3390/diagnostics14040441Radioactive Seed Localization for Nonpalpable Breast Lesions: Systematic Review and Meta-AnalysisHortência H. J. Ferreira0Carla Daruich de Souza1Lorena Pozzo2Martha S. Ribeiro3Maria Elisa C. M. Rostelato4Nuclear and Energy Research Institute (IPEN/CNEN—SP), University of São Paulo (USP), Av. Professor Lineu Prestes 2242, São Paulo 05508-000, SP, BrazilNuclear and Energy Research Institute (IPEN/CNEN—SP), University of São Paulo (USP), Av. Professor Lineu Prestes 2242, São Paulo 05508-000, SP, BrazilNuclear and Energy Research Institute (IPEN/CNEN—SP), University of São Paulo (USP), Av. Professor Lineu Prestes 2242, São Paulo 05508-000, SP, BrazilNuclear and Energy Research Institute (IPEN/CNEN—SP), University of São Paulo (USP), Av. Professor Lineu Prestes 2242, São Paulo 05508-000, SP, BrazilNuclear and Energy Research Institute (IPEN/CNEN—SP), University of São Paulo (USP), Av. Professor Lineu Prestes 2242, São Paulo 05508-000, SP, BrazilBackground: This study is a systematic review with meta-analysis comparing radioactive seed localization (RSL) versus radio-guided occult lesion localization (ROLL) and wire-guided localization (WGL) for patients with impalpable breast cancer undergoing breast-conserving surgery and evaluating efficacy, safety, and logistical outcomes. The protocol is registered in PROSPERO with the number CRD42022299726. Methods: A search was conducted in the Embase, Lilacs, Pubmed, Scielo, Web of Science, and clinicaltrials.gov databases, in addition to a manual search in the reference list of relevant articles, for randomized clinical trials and cohort studies. Studies selected were submitted to their own data extraction forms and risk of bias analysis according to the ROB 2 and ROBINS 1 tools. A meta-analysis was performed, considering the random effect model, calculating the relative risk or the mean difference for dichotomous or continuous data, respectively. The quality of the evidence generated was analyzed by outcome according to the GRADE tool. Overall, 46 articles met the inclusion criteria and were included in this systematic review; of these, 4 studies compared RSL and ROLL with a population of 1550 women, and 43 compared RSL and WGL with a population of 19,820 women. Results: The results showed that RSL is a superior method to WGL in terms of surgical efficiency in the impalpable breast lesions’ intraoperative localization, and it is at least equivalent to ROLL. Regarding security, RSL obtained results equivalent to the already established technique, the WGL. In addition to presenting promising results, RSL has been proven to be superior to WGL and ROLL technologies.https://www.mdpi.com/2075-4418/14/4/441breast-conserving surgeryintraoperative localizationradioactive seed localizationsystematic reviewmeta-analysis |
| spellingShingle | Hortência H. J. Ferreira Carla Daruich de Souza Lorena Pozzo Martha S. Ribeiro Maria Elisa C. M. Rostelato Radioactive Seed Localization for Nonpalpable Breast Lesions: Systematic Review and Meta-Analysis Diagnostics breast-conserving surgery intraoperative localization radioactive seed localization systematic review meta-analysis |
| title | Radioactive Seed Localization for Nonpalpable Breast Lesions: Systematic Review and Meta-Analysis |
| title_full | Radioactive Seed Localization for Nonpalpable Breast Lesions: Systematic Review and Meta-Analysis |
| title_fullStr | Radioactive Seed Localization for Nonpalpable Breast Lesions: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Radioactive Seed Localization for Nonpalpable Breast Lesions: Systematic Review and Meta-Analysis |
| title_short | Radioactive Seed Localization for Nonpalpable Breast Lesions: Systematic Review and Meta-Analysis |
| title_sort | radioactive seed localization for nonpalpable breast lesions systematic review and meta analysis |
| topic | breast-conserving surgery intraoperative localization radioactive seed localization systematic review meta-analysis |
| url | https://www.mdpi.com/2075-4418/14/4/441 |
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