Assessment and evaluation of Chitosan‐Metamizole nanoparticles for the fracture healing and analgesic effect: Preclinical study in rat model
Abstract To assess and evaluate Chitosan‐Metamizole nanoparticles for fracture healing and analgesic potential, nanoparticles were formulated using the ionotropic gelation method. The nanoparticles were evaluated for particle size, zeta potential, polydispersity index, loading efficiency, surface ch...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Hindawi-IET
2023-06-01
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| Series: | IET Nanobiotechnology |
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| Online Access: | https://doi.org/10.1049/nbt2.12131 |
| _version_ | 1797425760376455168 |
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| author | Li Yin Liyong Yuan Chunling Peng Qionghua Wang |
| author_facet | Li Yin Liyong Yuan Chunling Peng Qionghua Wang |
| author_sort | Li Yin |
| collection | DOAJ |
| description | Abstract To assess and evaluate Chitosan‐Metamizole nanoparticles for fracture healing and analgesic potential, nanoparticles were formulated using the ionotropic gelation method. The nanoparticles were evaluated for particle size, zeta potential, polydispersity index, loading efficiency, surface characteristics and drug release properties. The analgesic activity was determined in carrageenan‐induced arthritic male Wister rats. Further fracture healing potency, mechanical testing, radiographic examination and bone histology of the femur were studied. The drug loading efficiency of 11.38%–17.45%, particle size of 140–220 nm, and zeta potential of 19.12–23.14 mV were observed with a spherical, smooth appearance. Nanoparticles showed sustained release behaviour over a longer period. Nearly 4‐fold inhibition of oedema was observed in animals treated with nanoparticles with excellent fracture healing potential. The femurs treated with nanoparticles required greater force to fracture. Nanoparticles significantly improved the strength and healing process. Histopathological studies showed the potential of nanoparticles in the healing process. The study confirmed the potential of nanoparticles in fracture healing and enhancement of analgesic activity. |
| first_indexed | 2024-03-09T08:19:44Z |
| format | Article |
| id | doaj.art-8b731e2f9fcf4ba5bd339bcdc79c9452 |
| institution | Directory Open Access Journal |
| issn | 1751-8741 1751-875X |
| language | English |
| last_indexed | 2024-03-09T08:19:44Z |
| publishDate | 2023-06-01 |
| publisher | Hindawi-IET |
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| series | IET Nanobiotechnology |
| spelling | doaj.art-8b731e2f9fcf4ba5bd339bcdc79c94522023-12-02T21:51:44ZengHindawi-IETIET Nanobiotechnology1751-87411751-875X2023-06-0117436036710.1049/nbt2.12131Assessment and evaluation of Chitosan‐Metamizole nanoparticles for the fracture healing and analgesic effect: Preclinical study in rat modelLi Yin0Liyong Yuan1Chunling Peng2Qionghua Wang3Department of Anesthesiology Chongqing Jiangjin District Central Hospital Chongqing ChinaDepartment of Anesthesiology Ningbo NO.6 Hospital Ningbo Zhejiang ChinaDepartment of Anesthesiology Chongqing Jiangjin District Central Hospital Chongqing ChinaDepartment of Anesthesiology Chongqing Jiangjin District Central Hospital Chongqing ChinaAbstract To assess and evaluate Chitosan‐Metamizole nanoparticles for fracture healing and analgesic potential, nanoparticles were formulated using the ionotropic gelation method. The nanoparticles were evaluated for particle size, zeta potential, polydispersity index, loading efficiency, surface characteristics and drug release properties. The analgesic activity was determined in carrageenan‐induced arthritic male Wister rats. Further fracture healing potency, mechanical testing, radiographic examination and bone histology of the femur were studied. The drug loading efficiency of 11.38%–17.45%, particle size of 140–220 nm, and zeta potential of 19.12–23.14 mV were observed with a spherical, smooth appearance. Nanoparticles showed sustained release behaviour over a longer period. Nearly 4‐fold inhibition of oedema was observed in animals treated with nanoparticles with excellent fracture healing potential. The femurs treated with nanoparticles required greater force to fracture. Nanoparticles significantly improved the strength and healing process. Histopathological studies showed the potential of nanoparticles in the healing process. The study confirmed the potential of nanoparticles in fracture healing and enhancement of analgesic activity.https://doi.org/10.1049/nbt2.12131analgesicbonechitosanfracture healingmetamizolenanoparticles |
| spellingShingle | Li Yin Liyong Yuan Chunling Peng Qionghua Wang Assessment and evaluation of Chitosan‐Metamizole nanoparticles for the fracture healing and analgesic effect: Preclinical study in rat model IET Nanobiotechnology analgesic bone chitosan fracture healing metamizole nanoparticles |
| title | Assessment and evaluation of Chitosan‐Metamizole nanoparticles for the fracture healing and analgesic effect: Preclinical study in rat model |
| title_full | Assessment and evaluation of Chitosan‐Metamizole nanoparticles for the fracture healing and analgesic effect: Preclinical study in rat model |
| title_fullStr | Assessment and evaluation of Chitosan‐Metamizole nanoparticles for the fracture healing and analgesic effect: Preclinical study in rat model |
| title_full_unstemmed | Assessment and evaluation of Chitosan‐Metamizole nanoparticles for the fracture healing and analgesic effect: Preclinical study in rat model |
| title_short | Assessment and evaluation of Chitosan‐Metamizole nanoparticles for the fracture healing and analgesic effect: Preclinical study in rat model |
| title_sort | assessment and evaluation of chitosan metamizole nanoparticles for the fracture healing and analgesic effect preclinical study in rat model |
| topic | analgesic bone chitosan fracture healing metamizole nanoparticles |
| url | https://doi.org/10.1049/nbt2.12131 |
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