Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCoV-19) vaccine: report of two cases
Vaccination with ChAdOx1 nCoV-19 can result in vaccine-induced immune thrombotic thrombocytopenia (VITT). This phenomenon mimics heparin-induced thrombocytopenia, yet it does not require heparin as a trigger. This case report highlights the potentially lifethreatening complication associated with C...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2022-05-01
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| Series: | Bleeding, Thrombosis and Vascular Biology |
| Subjects: | |
| Online Access: | https://btvb.org/btvb/article/view/23 |
| _version_ | 1797835174921109504 |
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| author | Rita Carlotta Santoro Roberto Minici Marzia Leotta Mariapia Falbo Lucia Concetta Elia Francesca Leo Antonella Ierardi Alessandra Strangio Simona Prejanò |
| author_facet | Rita Carlotta Santoro Roberto Minici Marzia Leotta Mariapia Falbo Lucia Concetta Elia Francesca Leo Antonella Ierardi Alessandra Strangio Simona Prejanò |
| author_sort | Rita Carlotta Santoro |
| collection | DOAJ |
| description |
Vaccination with ChAdOx1 nCoV-19 can result in vaccine-induced immune thrombotic thrombocytopenia (VITT). This phenomenon mimics heparin-induced thrombocytopenia, yet it does not require heparin as a trigger. This case report highlights the potentially lifethreatening complication associated with ChAdOx1 nCov-19 vaccine, clinical presentation, diagnostic approach, and treatment. We report two cases of vaccine-induced immune thrombotic thrombocytopenia after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. We attribute these thrombotic conditions to the vaccine due to the remarkable temporal relationship. The proposed mechanism of VITT is a production of antibodies against platelet factor-4 resulting in massive platelet activation. Healthcare providers should be aware of the possibility of such a fatal complication, and the vaccine recipients should be warned about the symptoms of VITT.
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| first_indexed | 2024-04-09T14:48:59Z |
| format | Article |
| id | doaj.art-8b7321d08d4d4f3e8584a0bd18571035 |
| institution | Directory Open Access Journal |
| issn | 2785-5309 |
| language | English |
| last_indexed | 2024-04-09T14:48:59Z |
| publishDate | 2022-05-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Bleeding, Thrombosis and Vascular Biology |
| spelling | doaj.art-8b7321d08d4d4f3e8584a0bd185710352023-05-02T10:09:35ZengPAGEPress PublicationsBleeding, Thrombosis and Vascular Biology2785-53092022-05-011210.4081/btvb.2022.23Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCoV-19) vaccine: report of two casesRita Carlotta Santoro0Roberto Minici1Marzia Leotta2Mariapia Falbo3Lucia Concetta Elia4Francesca Leo5Antonella Ierardi6Alessandra Strangio7Simona Prejanò8Hemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, CatanzaroDiagnostic Radiology Unit, Azienda Ospedaliera Pugliese-Ciaccio, CatanzaroHemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, CatanzaroHemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, CatanzaroHemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, CatanzaroHemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, CatanzaroHemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, CatanzaroHemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, CatanzaroHemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro Vaccination with ChAdOx1 nCoV-19 can result in vaccine-induced immune thrombotic thrombocytopenia (VITT). This phenomenon mimics heparin-induced thrombocytopenia, yet it does not require heparin as a trigger. This case report highlights the potentially lifethreatening complication associated with ChAdOx1 nCov-19 vaccine, clinical presentation, diagnostic approach, and treatment. We report two cases of vaccine-induced immune thrombotic thrombocytopenia after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. We attribute these thrombotic conditions to the vaccine due to the remarkable temporal relationship. The proposed mechanism of VITT is a production of antibodies against platelet factor-4 resulting in massive platelet activation. Healthcare providers should be aware of the possibility of such a fatal complication, and the vaccine recipients should be warned about the symptoms of VITT. https://btvb.org/btvb/article/view/23ThrombosisThrombocytopeniaVaccineSARS-CoV-2 |
| spellingShingle | Rita Carlotta Santoro Roberto Minici Marzia Leotta Mariapia Falbo Lucia Concetta Elia Francesca Leo Antonella Ierardi Alessandra Strangio Simona Prejanò Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCoV-19) vaccine: report of two cases Bleeding, Thrombosis and Vascular Biology Thrombosis Thrombocytopenia Vaccine SARS-CoV-2 |
| title | Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCoV-19) vaccine: report of two cases |
| title_full | Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCoV-19) vaccine: report of two cases |
| title_fullStr | Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCoV-19) vaccine: report of two cases |
| title_full_unstemmed | Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCoV-19) vaccine: report of two cases |
| title_short | Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCoV-19) vaccine: report of two cases |
| title_sort | vaccine induced immune thrombotic thrombocytopenia following astrazeneca chadox1 ncov 19 vaccine report of two cases |
| topic | Thrombosis Thrombocytopenia Vaccine SARS-CoV-2 |
| url | https://btvb.org/btvb/article/view/23 |
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