Metformin protects trabecular meshwork against oxidative injury via activating integrin/ROCK signals

Metformin protects trabecular meshwork against oxidative injury via activating integrin/ROCK signals

This study aimed to investigate the protective effect of metformin on trabecular meshwork (TM) and explore its molecular mechanisms in vivo and in vitro. Ocular hypertension (OHT) mouse models were induced with dexamethasone and further treated with metformin to determine the intraocular pressure (I...

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Bibliographic Details
Main Authors: Lijuan Xu, Xinyao Zhang, Yin Zhao, Xiaorui Gang, Tao Zhou, Jialing Han, Yang Cao, Binyan Qi, Shuning Song, Xiaojie Wang, Yuanbo Liang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
open-angle glaucoma
trabecular meshwork
cytoskeleton remodelling
metformin
Online Access:https://elifesciences.org/articles/81198

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