Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Etodolac Derivatives
Three new hydrazone derivatives of Etodolac were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method. All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy, and 1HNMR analysis. The synthesis of the ta...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2019-06-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/942 |
| _version_ | 1828412752964616192 |
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| author | Omeed M. Hassan Susan W. Sarsam |
| author_facet | Omeed M. Hassan Susan W. Sarsam |
| author_sort | Omeed M. Hassan |
| collection | DOAJ |
| description |
Three new hydrazone derivatives of Etodolac were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method. All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy, and 1HNMR analysis. The synthesis of the target (P1-P3) compounds was accomplished following multistep reaction procedures. The synthesized target compounds were found to be active in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Etodolac).
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| first_indexed | 2024-12-10T12:54:28Z |
| format | Article |
| id | doaj.art-8b74ae7b05494743a2bfe31e51c8067e |
| institution | Directory Open Access Journal |
| issn | 2521-3512 1683-3597 |
| language | English |
| last_indexed | 2024-12-10T12:54:28Z |
| publishDate | 2019-06-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-8b74ae7b05494743a2bfe31e51c8067e2022-12-22T01:48:08ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972019-06-0128110.31351/vol28iss1pp106-112Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Etodolac DerivativesOmeed M. HassanSusan W. Sarsam Three new hydrazone derivatives of Etodolac were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method. All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy, and 1HNMR analysis. The synthesis of the target (P1-P3) compounds was accomplished following multistep reaction procedures. The synthesized target compounds were found to be active in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Etodolac). https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/942: Etodolac hydrazone derivatives, Anti-inflammatory, Paw edema method. |
| spellingShingle | Omeed M. Hassan Susan W. Sarsam Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Etodolac Derivatives Iraqi Journal of Pharmaceutical Sciences : Etodolac hydrazone derivatives, Anti-inflammatory, Paw edema method. |
| title | Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Etodolac Derivatives |
| title_full | Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Etodolac Derivatives |
| title_fullStr | Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Etodolac Derivatives |
| title_full_unstemmed | Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Etodolac Derivatives |
| title_short | Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Etodolac Derivatives |
| title_sort | synthesis characterization and preliminary anti inflammatory evaluation of new etodolac derivatives |
| topic | : Etodolac hydrazone derivatives, Anti-inflammatory, Paw edema method. |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/942 |
| work_keys_str_mv | AT omeedmhassan synthesischaracterizationandpreliminaryantiinflammatoryevaluationofnewetodolacderivatives AT susanwsarsam synthesischaracterizationandpreliminaryantiinflammatoryevaluationofnewetodolacderivatives |