Puromycin aminonucleoside‐induced podocyte injury is ameliorated by the Smad3 inhibitor SIS3

Puromycin aminonucleoside‐induced podocyte injury is ameliorated by the Smad3 inhibitor SIS3

Smad3 signaling and transgelin expression are often activated during puromycin aminonucleoside (PAN)‐induced podocyte injury. Here, we investigated whether the Smad3 inhibitor SIS3 can ameliorate damage to injured podocytes. A model of PAN‐induced podocyte injury was constructed using the MPC5 cell...

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Bibliographic Details
Main Authors: Lina Jiang, Hong Cui, Jie Ding, Aijun Yang, Yingchao Zhang
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:FEBS Open Bio
Subjects:
podocyte injury
puromycin aminonucleoside
smad3
transgelin
Online Access:https://doi.org/10.1002/2211-5463.12916

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