Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment

Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely unknown. Using single-cell transcriptomics, we identified a distinct subpopulation of old HSCs carrying a p53 signature indicative of stem c...

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Bibliographic Details
Main Authors: Kristina Kirschner, Tamir Chandra, Vladimir Kiselev, David Flores-Santa Cruz, Iain C. Macaulay, Hyun Jun Park, Juan Li, David G. Kent, Rupa Kumar, Dean C. Pask, Tina L. Hamilton, Martin Hemberg, Wolf Reik, Anthony R. Green
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
aging
scRNA-seq
hematology
JAK2
p53
stem cells
cellular aging
cancer
leukemia
genomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306034

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