Secreted NS1 proteins of tick-borne encephalitis virus and West Nile virus block dendritic cell activation and effector functions

Secreted NS1 proteins of tick-borne encephalitis virus and West Nile virus block dendritic cell activation and effector functions

ABSTRACT The flavivirus non-structural protein 1 (NS1) is secreted from infected cells into the circulation and the serum levels correlate with disease severity. The effect of secreted NS1 (sNS1) on non-infected mammalian immune cells is largely unknown. Here, we expressed recombinant sNS1 proteins...

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Bibliographic Details
Main Authors: António A. R. Camarão, Olivia Luise Gern, Felix Stegmann, Felix Mulenge, Bibiana Costa, Babak Saremi, Klaus Jung, Bernd Lepenies, Ulrich Kalinke, Imke Steffen
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
flavivirus
non-structural protein 1
tick-borne encephalitis virus
West Nile virus
dendritic cells
innate immunity
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02192-23

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