Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma
Abstract A recent study on 15 patients with synovial sarcoma demonstrated very low prevalence of tumor-specific fusion transcripts in peripheral blood specimens. Our results in an independent cohort of 38 patients with synovial sarcoma support these findings. Synovial sarcoma patients could greatly...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13000-019-0800-x |
| _version_ | 1818301065368436736 |
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| author | Joanna Przybyl Matt van de Rijn Piotr Rutkowski |
| author_facet | Joanna Przybyl Matt van de Rijn Piotr Rutkowski |
| author_sort | Joanna Przybyl |
| collection | DOAJ |
| description | Abstract A recent study on 15 patients with synovial sarcoma demonstrated very low prevalence of tumor-specific fusion transcripts in peripheral blood specimens. Our results in an independent cohort of 38 patients with synovial sarcoma support these findings. Synovial sarcoma patients could greatly benefit from a non-invasive monitoring of tumor burden by liquid biopsies. However, given the low detection rate of SS18-SSX1/2 in circulation, we conclude that alternative markers other than the tumor-type specific fusion transcripts should be considered. |
| first_indexed | 2024-12-13T05:17:05Z |
| format | Article |
| id | doaj.art-8b8024e7e421463782002659a0bf4b67 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-13T05:17:05Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-8b8024e7e421463782002659a0bf4b672022-12-21T23:58:24ZengBMCDiagnostic Pathology1746-15962019-03-011411210.1186/s13000-019-0800-xDetection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcomaJoanna Przybyl0Matt van de Rijn1Piotr Rutkowski2Department of Pathology, Stanford University School of MedicineDepartment of Pathology, Stanford University School of MedicineDepartment of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Institute - Oncology CenterAbstract A recent study on 15 patients with synovial sarcoma demonstrated very low prevalence of tumor-specific fusion transcripts in peripheral blood specimens. Our results in an independent cohort of 38 patients with synovial sarcoma support these findings. Synovial sarcoma patients could greatly benefit from a non-invasive monitoring of tumor burden by liquid biopsies. However, given the low detection rate of SS18-SSX1/2 in circulation, we conclude that alternative markers other than the tumor-type specific fusion transcripts should be considered.http://link.springer.com/article/10.1186/s13000-019-0800-xLiquid biopsyCirculating tumor cells (CTCs)Nested RT-PCRSS18-SSX fusion transcriptSynovial sarcoma |
| spellingShingle | Joanna Przybyl Matt van de Rijn Piotr Rutkowski Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma Diagnostic Pathology Liquid biopsy Circulating tumor cells (CTCs) Nested RT-PCR SS18-SSX fusion transcript Synovial sarcoma |
| title | Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma |
| title_full | Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma |
| title_fullStr | Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma |
| title_full_unstemmed | Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma |
| title_short | Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma |
| title_sort | detection of ss18 ssx1 2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma |
| topic | Liquid biopsy Circulating tumor cells (CTCs) Nested RT-PCR SS18-SSX fusion transcript Synovial sarcoma |
| url | http://link.springer.com/article/10.1186/s13000-019-0800-x |
| work_keys_str_mv | AT joannaprzybyl detectionofss18ssx12fusiontranscriptsincirculatingtumorcellsofpatientswithsynovialsarcoma AT mattvanderijn detectionofss18ssx12fusiontranscriptsincirculatingtumorcellsofpatientswithsynovialsarcoma AT piotrrutkowski detectionofss18ssx12fusiontranscriptsincirculatingtumorcellsofpatientswithsynovialsarcoma |