Rational Use of Antibiotics in Postoperative Class 1 Wound: A Prospective Study
Introduction: Surgical Site Infections (SSI) are the cause of significant postoperative morbidity. The role of antibiotics and its rational use for the prevention of operative wound infections has been an area of interest for research. Aim: To compare the incidence of SSI in postoperative class...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Pvt. Ltd.
2020-10-01
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| Series: | International Journal of Anatomy Radiology and Surgery |
| Subjects: | |
| Online Access: | http://www.ijars.net/articles/PDF/2567/44297_CE[Ra1]_F(SHU)_PF1(AG_SHU)_PFA(SHU)_PB(AG_SHU)_PN(SHU)_PF2_(MG_OM).pdf |
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| author | Junaid Minhaj Shaikh Muzaffar Ali Qamar Ravindra Rangrao Mistry |
| author_facet | Junaid Minhaj Shaikh Muzaffar Ali Qamar Ravindra Rangrao Mistry |
| author_sort | Junaid Minhaj Shaikh |
| collection | DOAJ |
| description | Introduction: Surgical Site Infections (SSI) are the cause of
significant postoperative morbidity. The role of antibiotics and
its rational use for the prevention of operative wound infections
has been an area of interest for research.
Aim: To compare the incidence of SSI in postoperative class 1
wound with single dose antibiotic use and its empirical doses.
Materials and Methods: The present study, was a prospective
cross-sectional study in which two groups of patients were
classified based on usage on antibiotics. Study Group included
100 patients who were given single dose antibiotic (Injection
amoxicillin+clavulanic acid in a dose as per weight) within half
an hour before the incision for the procedure with no antibiotics
being prescribed after the surgical procedure. Control Group
included 100 patients who were prescribed antibiotic (Injection
amoxicillin + clavulanic acid in a dose as per weight) before the
incision for the procedure as well as empirical antibiotics for
five days or more after the surgical procedure. Operative wound
was examined on day 5, day 8, day 10, day 15 postoperative
days, for signs of SSI. Graph Pad online calculator was used
for analysis.
Results: Of the 100 patients who underwent clean surgery and
received only one dose of preoperative prophylactic antibiotic,
three of these patients developed features of SSI (3%). Of
the 100 patients who underwent clean surgery and received
preoperatively single dose of antibiotics and postoperatively
empirical antibiotics for more than five days, two of these
patients developed features of SSI (2%) on day five. The
difference between groups was statistically not significant
(p-0.65). Similarly, the difference was not significant on day 8
(p-0.65) and day 10 (p-0.65), there was no difference between
groups at day 15 (p=0.32).
Conclusion: Single dose of antibiotic prophylaxis was
therapeutically almost as efficient in comparison with multiple
doses of postoperative antibiotic usage for prevention of SSI in
uncomplicated elective clean surgery in studied patients. |
| first_indexed | 2024-12-16T11:18:12Z |
| format | Article |
| id | doaj.art-8b80a2af891a41a483f3b5cee64721b8 |
| institution | Directory Open Access Journal |
| issn | 2277-8543 2455-6874 |
| language | English |
| last_indexed | 2024-12-16T11:18:12Z |
| publishDate | 2020-10-01 |
| publisher | JCDR Research and Publications Pvt. Ltd. |
| record_format | Article |
| series | International Journal of Anatomy Radiology and Surgery |
| spelling | doaj.art-8b80a2af891a41a483f3b5cee64721b82022-12-21T22:33:32ZengJCDR Research and Publications Pvt. Ltd.International Journal of Anatomy Radiology and Surgery2277-85432455-68742020-10-0194010310.7860/IJARS/2020/44297:2567Rational Use of Antibiotics in Postoperative Class 1 Wound: A Prospective StudyJunaid Minhaj Shaikh0Muzaffar Ali Qamar 1Ravindra Rangrao Mistry2Associate Professor, Department of Surgery, Government Medical College, Aurangabad, Maharashtra, IndiaAliAssociate Professor, Department of Surgery, Government Medical College, Aurangabad, Maharashtra, India.Introduction: Surgical Site Infections (SSI) are the cause of significant postoperative morbidity. The role of antibiotics and its rational use for the prevention of operative wound infections has been an area of interest for research. Aim: To compare the incidence of SSI in postoperative class 1 wound with single dose antibiotic use and its empirical doses. Materials and Methods: The present study, was a prospective cross-sectional study in which two groups of patients were classified based on usage on antibiotics. Study Group included 100 patients who were given single dose antibiotic (Injection amoxicillin+clavulanic acid in a dose as per weight) within half an hour before the incision for the procedure with no antibiotics being prescribed after the surgical procedure. Control Group included 100 patients who were prescribed antibiotic (Injection amoxicillin + clavulanic acid in a dose as per weight) before the incision for the procedure as well as empirical antibiotics for five days or more after the surgical procedure. Operative wound was examined on day 5, day 8, day 10, day 15 postoperative days, for signs of SSI. Graph Pad online calculator was used for analysis. Results: Of the 100 patients who underwent clean surgery and received only one dose of preoperative prophylactic antibiotic, three of these patients developed features of SSI (3%). Of the 100 patients who underwent clean surgery and received preoperatively single dose of antibiotics and postoperatively empirical antibiotics for more than five days, two of these patients developed features of SSI (2%) on day five. The difference between groups was statistically not significant (p-0.65). Similarly, the difference was not significant on day 8 (p-0.65) and day 10 (p-0.65), there was no difference between groups at day 15 (p=0.32). Conclusion: Single dose of antibiotic prophylaxis was therapeutically almost as efficient in comparison with multiple doses of postoperative antibiotic usage for prevention of SSI in uncomplicated elective clean surgery in studied patients.http://www.ijars.net/articles/PDF/2567/44297_CE[Ra1]_F(SHU)_PF1(AG_SHU)_PFA(SHU)_PB(AG_SHU)_PN(SHU)_PF2_(MG_OM).pdfclean woundprophylactic antibioticssurgical site infection |
| spellingShingle | Junaid Minhaj Shaikh Muzaffar Ali Qamar Ravindra Rangrao Mistry Rational Use of Antibiotics in Postoperative Class 1 Wound: A Prospective Study International Journal of Anatomy Radiology and Surgery clean wound prophylactic antibiotics surgical site infection |
| title | Rational Use of Antibiotics in Postoperative Class 1 Wound: A Prospective Study |
| title_full | Rational Use of Antibiotics in Postoperative Class 1 Wound: A Prospective Study |
| title_fullStr | Rational Use of Antibiotics in Postoperative Class 1 Wound: A Prospective Study |
| title_full_unstemmed | Rational Use of Antibiotics in Postoperative Class 1 Wound: A Prospective Study |
| title_short | Rational Use of Antibiotics in Postoperative Class 1 Wound: A Prospective Study |
| title_sort | rational use of antibiotics in postoperative class 1 wound a prospective study |
| topic | clean wound prophylactic antibiotics surgical site infection |
| url | http://www.ijars.net/articles/PDF/2567/44297_CE[Ra1]_F(SHU)_PF1(AG_SHU)_PFA(SHU)_PB(AG_SHU)_PN(SHU)_PF2_(MG_OM).pdf |
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