Exposure to Olfactory Alcohol Cues During Non-rapid Eye Movement Sleep Did Not Decrease Craving in Patients With Alcohol Dependence
Background and ObjectivesCue exposure therapy (CET) has been used to reduce alcohol use, but the effect of CET during sleep on alcohol dependence (AD) is unclear. The present study examined the effect of repeated exposure to an olfactory stimulus during non-rapid eye movement (NREM) sleep on cue rea...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.837573/full |
| _version_ | 1811328475610480640 |
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| author | Ran Zhu Zhaojun Ni Ran Tao Jun Cheng Liangjun Pang Shun Zhang Yang Zhang Yanxue Xue Yundong Ma Wei Sun Lin Lu Lin Lu Lin Lu Jiahui Deng Hongqiang Sun |
| author_facet | Ran Zhu Zhaojun Ni Ran Tao Jun Cheng Liangjun Pang Shun Zhang Yang Zhang Yanxue Xue Yundong Ma Wei Sun Lin Lu Lin Lu Lin Lu Jiahui Deng Hongqiang Sun |
| author_sort | Ran Zhu |
| collection | DOAJ |
| description | Background and ObjectivesCue exposure therapy (CET) has been used to reduce alcohol use, but the effect of CET during sleep on alcohol dependence (AD) is unclear. The present study examined the effect of repeated exposure to an olfactory stimulus during non-rapid eye movement (NREM) sleep on cue reactivity and craving in patients with AD.MethodsThirty-five patients with AD were enrolled according to the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV). All the subjects were randomly assigned to the experimental or control group. The experimental group was exposed to alcohol odor for 10 min during NREM sleep. The other group (controls) was exposed to water [control stimulus (CtrS)] for 10 min during NREM sleep. Demographic, alcohol-related, and clinical characteristics were collected at baseline. A cue-reactivity test was conducted before and after exposure to evaluate the effect of memory manipulation on acute response to an alcohol stimulus.ResultsThere were no significant time × group interactions according to the visual analog scale (VAS) score of craving intensity, skin conductance response (SCR), systolic blood pressure (SBP), and diastolic blood pressure (DBP; all p > 0.05). Two-way ANOVA showed significant main effects of time on SCR [F(1,33) = 4.453, p = 0.043], SBP [F(1,33) = 14.532, p = 0.001], DBP [F(1,33) = 8.327, p = 0.007], Craving-VAS [F(1,33) = 1.997, p = 0.167] in two groups.ConclusionExposure to olfactory alcohol cues during NREM sleep had no significant effect on alcohol craving in subjects with AD during hospitalization. |
| first_indexed | 2024-04-13T15:26:57Z |
| format | Article |
| id | doaj.art-8b8331ba2e1d46569194aca37854c59a |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-13T15:26:57Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-8b8331ba2e1d46569194aca37854c59a2022-12-22T02:41:30ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-04-011310.3389/fpsyt.2022.837573837573Exposure to Olfactory Alcohol Cues During Non-rapid Eye Movement Sleep Did Not Decrease Craving in Patients With Alcohol DependenceRan Zhu0Zhaojun Ni1Ran Tao2Jun Cheng3Liangjun Pang4Shun Zhang5Yang Zhang6Yanxue Xue7Yundong Ma8Wei Sun9Lin Lu10Lin Lu11Lin Lu12Jiahui Deng13Hongqiang Sun14NHC Key Laboratory of Mental Health, Peking University Institute of Mental Health, Peking University Sixth Hospital, Peking University, Beijing, ChinaNHC Key Laboratory of Mental Health, Peking University Institute of Mental Health, Peking University Sixth Hospital, Peking University, Beijing, ChinaNHC Key Laboratory of Mental Health, Peking University Institute of Mental Health, Peking University Sixth Hospital, Peking University, Beijing, ChinaAnhui Mental Health Center, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaKailuan Mental Health Center, Tangshan, ChinaNHC Key Laboratory of Mental Health, Peking University Institute of Mental Health, Peking University Sixth Hospital, Peking University, Beijing, ChinaNational Institute on Drug Dependence, Peking University, Beijing, ChinaNHC Key Laboratory of Mental Health, Peking University Institute of Mental Health, Peking University Sixth Hospital, Peking University, Beijing, ChinaNHC Key Laboratory of Mental Health, Peking University Institute of Mental Health, Peking University Sixth Hospital, Peking University, Beijing, ChinaNHC Key Laboratory of Mental Health, Peking University Institute of Mental Health, Peking University Sixth Hospital, Peking University, Beijing, ChinaNational Institute on Drug Dependence, Peking University, Beijing, ChinaPeking-Tsinghua Center for Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, ChinaNHC Key Laboratory of Mental Health, Peking University Institute of Mental Health, Peking University Sixth Hospital, Peking University, Beijing, ChinaNHC Key Laboratory of Mental Health, Peking University Institute of Mental Health, Peking University Sixth Hospital, Peking University, Beijing, ChinaBackground and ObjectivesCue exposure therapy (CET) has been used to reduce alcohol use, but the effect of CET during sleep on alcohol dependence (AD) is unclear. The present study examined the effect of repeated exposure to an olfactory stimulus during non-rapid eye movement (NREM) sleep on cue reactivity and craving in patients with AD.MethodsThirty-five patients with AD were enrolled according to the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV). All the subjects were randomly assigned to the experimental or control group. The experimental group was exposed to alcohol odor for 10 min during NREM sleep. The other group (controls) was exposed to water [control stimulus (CtrS)] for 10 min during NREM sleep. Demographic, alcohol-related, and clinical characteristics were collected at baseline. A cue-reactivity test was conducted before and after exposure to evaluate the effect of memory manipulation on acute response to an alcohol stimulus.ResultsThere were no significant time × group interactions according to the visual analog scale (VAS) score of craving intensity, skin conductance response (SCR), systolic blood pressure (SBP), and diastolic blood pressure (DBP; all p > 0.05). Two-way ANOVA showed significant main effects of time on SCR [F(1,33) = 4.453, p = 0.043], SBP [F(1,33) = 14.532, p = 0.001], DBP [F(1,33) = 8.327, p = 0.007], Craving-VAS [F(1,33) = 1.997, p = 0.167] in two groups.ConclusionExposure to olfactory alcohol cues during NREM sleep had no significant effect on alcohol craving in subjects with AD during hospitalization.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.837573/fullalcohol dependencesleepcue exposure therapycravingalcohol odor |
| spellingShingle | Ran Zhu Zhaojun Ni Ran Tao Jun Cheng Liangjun Pang Shun Zhang Yang Zhang Yanxue Xue Yundong Ma Wei Sun Lin Lu Lin Lu Lin Lu Jiahui Deng Hongqiang Sun Exposure to Olfactory Alcohol Cues During Non-rapid Eye Movement Sleep Did Not Decrease Craving in Patients With Alcohol Dependence Frontiers in Psychiatry alcohol dependence sleep cue exposure therapy craving alcohol odor |
| title | Exposure to Olfactory Alcohol Cues During Non-rapid Eye Movement Sleep Did Not Decrease Craving in Patients With Alcohol Dependence |
| title_full | Exposure to Olfactory Alcohol Cues During Non-rapid Eye Movement Sleep Did Not Decrease Craving in Patients With Alcohol Dependence |
| title_fullStr | Exposure to Olfactory Alcohol Cues During Non-rapid Eye Movement Sleep Did Not Decrease Craving in Patients With Alcohol Dependence |
| title_full_unstemmed | Exposure to Olfactory Alcohol Cues During Non-rapid Eye Movement Sleep Did Not Decrease Craving in Patients With Alcohol Dependence |
| title_short | Exposure to Olfactory Alcohol Cues During Non-rapid Eye Movement Sleep Did Not Decrease Craving in Patients With Alcohol Dependence |
| title_sort | exposure to olfactory alcohol cues during non rapid eye movement sleep did not decrease craving in patients with alcohol dependence |
| topic | alcohol dependence sleep cue exposure therapy craving alcohol odor |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.837573/full |
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