Progression of cardiac allograft vasculopathy assessed by serial three-vessel quantitative coronary angiography.
BACKGROUND:The purpose of the present study was to assess the short- and long-term progression of cardiac allograft vasculopathy (CAV) using serial 3-vessel quantitative coronary angiography (QCA). METHODS:CAV progression was assessed using serial 3-vessel QCA analysis at baseline, 1-year and long-t...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6110499?pdf=render |
| _version_ | 1819261596320399360 |
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| author | Christian Zanchin Kyohei Yamaji Carolin Rogge Dorothea Lesche Thomas Zanchin Yasushi Ueki Stephan Windecker Paul Mohacsi Lorenz Räber Vilborg Sigurdardottir |
| author_facet | Christian Zanchin Kyohei Yamaji Carolin Rogge Dorothea Lesche Thomas Zanchin Yasushi Ueki Stephan Windecker Paul Mohacsi Lorenz Räber Vilborg Sigurdardottir |
| author_sort | Christian Zanchin |
| collection | DOAJ |
| description | BACKGROUND:The purpose of the present study was to assess the short- and long-term progression of cardiac allograft vasculopathy (CAV) using serial 3-vessel quantitative coronary angiography (QCA). METHODS:CAV progression was assessed using serial 3-vessel QCA analysis at baseline, 1-year and long-term angiographic follow-up (8.5±3.7 years) after heart transplantation. The change in minimal lumen diameter (MLD) and percent diameter stenosis (%DS) was serially assessed within matched segments. Patients were graded according to the ISHLT-CAV classification and grouped as ISHLT-CAV0 and ISHLT-CAV1-3. The primary endpoint was mean change in MLD and %DS. RESULTS:A total of 41 patients and 520 matched segments were available for serial 3-vessel QCA. Overall, MLD decreased non-significantly from baseline to 1-year follow-up and significantly from 1-year to the long-term angiographic follow-up (Δ-0.08mm/year [95%CI -0.11 to -0.05], P<0.001). %DS increased significantly from baseline to 1-year (Δ+0.96%/year [95%CI 0.04 to 1.88], P = 0.041) and from 1-year to long-term angiographic follow-up (Δ+0.61%/year [95%CI 0.33 to 0.88], P<0.001). ISHLT-CAV1-3 at 1 year and at long-term angiographic follow-up was observed in 22% and 61%, respectively. Between baseline and long-term angiographic follow-up, a significant reduction in MLD was observed within both groups without a significant difference in the reduction between the two groups (ISHLT-CAV0: median -0.49mm [IQR -0.54 to -0.43] vs. ISHLT-CAV1-3: median -0.40mm [IQR -0.44 to -0.35], P = 0.4). CONCLUSION:The current data suggest that QCA can't predict CAV beyond 1 year, but, QCA affirmed that CAV progresses to a similar extent in patients who do not develop visual CAV during long-term follow-up. |
| first_indexed | 2024-12-23T19:44:19Z |
| format | Article |
| id | doaj.art-8b83ab5acdce45968f21974c6895d4e1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T19:44:19Z |
| publishDate | 2018-01-01 |
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| spelling | doaj.art-8b83ab5acdce45968f21974c6895d4e12022-12-21T17:33:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01138e020295010.1371/journal.pone.0202950Progression of cardiac allograft vasculopathy assessed by serial three-vessel quantitative coronary angiography.Christian ZanchinKyohei YamajiCarolin RoggeDorothea LescheThomas ZanchinYasushi UekiStephan WindeckerPaul MohacsiLorenz RäberVilborg SigurdardottirBACKGROUND:The purpose of the present study was to assess the short- and long-term progression of cardiac allograft vasculopathy (CAV) using serial 3-vessel quantitative coronary angiography (QCA). METHODS:CAV progression was assessed using serial 3-vessel QCA analysis at baseline, 1-year and long-term angiographic follow-up (8.5±3.7 years) after heart transplantation. The change in minimal lumen diameter (MLD) and percent diameter stenosis (%DS) was serially assessed within matched segments. Patients were graded according to the ISHLT-CAV classification and grouped as ISHLT-CAV0 and ISHLT-CAV1-3. The primary endpoint was mean change in MLD and %DS. RESULTS:A total of 41 patients and 520 matched segments were available for serial 3-vessel QCA. Overall, MLD decreased non-significantly from baseline to 1-year follow-up and significantly from 1-year to the long-term angiographic follow-up (Δ-0.08mm/year [95%CI -0.11 to -0.05], P<0.001). %DS increased significantly from baseline to 1-year (Δ+0.96%/year [95%CI 0.04 to 1.88], P = 0.041) and from 1-year to long-term angiographic follow-up (Δ+0.61%/year [95%CI 0.33 to 0.88], P<0.001). ISHLT-CAV1-3 at 1 year and at long-term angiographic follow-up was observed in 22% and 61%, respectively. Between baseline and long-term angiographic follow-up, a significant reduction in MLD was observed within both groups without a significant difference in the reduction between the two groups (ISHLT-CAV0: median -0.49mm [IQR -0.54 to -0.43] vs. ISHLT-CAV1-3: median -0.40mm [IQR -0.44 to -0.35], P = 0.4). CONCLUSION:The current data suggest that QCA can't predict CAV beyond 1 year, but, QCA affirmed that CAV progresses to a similar extent in patients who do not develop visual CAV during long-term follow-up.http://europepmc.org/articles/PMC6110499?pdf=render |
| spellingShingle | Christian Zanchin Kyohei Yamaji Carolin Rogge Dorothea Lesche Thomas Zanchin Yasushi Ueki Stephan Windecker Paul Mohacsi Lorenz Räber Vilborg Sigurdardottir Progression of cardiac allograft vasculopathy assessed by serial three-vessel quantitative coronary angiography. PLoS ONE |
| title | Progression of cardiac allograft vasculopathy assessed by serial three-vessel quantitative coronary angiography. |
| title_full | Progression of cardiac allograft vasculopathy assessed by serial three-vessel quantitative coronary angiography. |
| title_fullStr | Progression of cardiac allograft vasculopathy assessed by serial three-vessel quantitative coronary angiography. |
| title_full_unstemmed | Progression of cardiac allograft vasculopathy assessed by serial three-vessel quantitative coronary angiography. |
| title_short | Progression of cardiac allograft vasculopathy assessed by serial three-vessel quantitative coronary angiography. |
| title_sort | progression of cardiac allograft vasculopathy assessed by serial three vessel quantitative coronary angiography |
| url | http://europepmc.org/articles/PMC6110499?pdf=render |
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