ANTIPLATELET TREATMENT IN ST ELEVATION ACUTE CORONARY SYNDROME UNDER REAL CLINICAL CIRCUMSTANCES: THE DYNAMICS OF THROMBOCYTE FUNCTION
Aim. To evaluate the dynamics of thrombocyte functional activity (TFA) under antiplatelet treatment conditions which include the branded, and generic compounds as well, in ST elevation acute coronary syndrome patients (STEACS) in routine clinical practice.Material and methods. The open-label prospec...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2017-02-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/567 |
| _version_ | 1797856893712990208 |
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| author | L. I. Malinova N. V. Furman P. V. Dolotovskaya N. F. Puchinian I. Yu. Radaeva |
| author_facet | L. I. Malinova N. V. Furman P. V. Dolotovskaya N. F. Puchinian I. Yu. Radaeva |
| author_sort | L. I. Malinova |
| collection | DOAJ |
| description | Aim. To evaluate the dynamics of thrombocyte functional activity (TFA) under antiplatelet treatment conditions which include the branded, and generic compounds as well, in ST elevation acute coronary syndrome patients (STEACS) in routine clinical practice.Material and methods. The open-label prospective study was done, including STEACS patients stratified according to the kind of antiplatelet in-patient treatment (original and/or generics). As an endpoint, we used the surrogate — functional activity of thrombocytes (TFA), measured by impedance and luminescent aggregatometry at 1 and 7 day from STEACS onset.Results. By the inclusion, baseline point all patients were comparable by TFA. On double antiplatelet therapy (DAT) by the 7th day of STEACS there was statistically significant difference of all ADP-induced thrombocyte aggregation. There was difference in ADP-induced platelet aggregation depending on the DAT variant, which included the original drug and generic.Conclusion. In STEACS patients the level of aggregation activity of platelets does significantly differ from the kind of antiplatelet treatment. Usage of the branded and generic compounds of the came antiplatelet agent by the same regimen does differ by different grade and dynamics of platelets activeness suppression. |
| first_indexed | 2024-04-09T20:48:58Z |
| format | Article |
| id | doaj.art-8b83fa41ecef4dbea9ef652871b8970c |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:48:58Z |
| publishDate | 2017-02-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-8b83fa41ecef4dbea9ef652871b8970c2023-03-29T21:23:27Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202017-02-0101828810.15829/1560-4071-2017-1-82-88713ANTIPLATELET TREATMENT IN ST ELEVATION ACUTE CORONARY SYNDROME UNDER REAL CLINICAL CIRCUMSTANCES: THE DYNAMICS OF THROMBOCYTE FUNCTIONL. I. Malinova0N. V. Furman1P. V. Dolotovskaya2N. F. Puchinian3I. Yu. Radaeva4SRI of Cardiology of the V. I. Razumovskiy Research Institute of Cardiology of Saratov Medical UniversitySRI of Cardiology of the V. I. Razumovskiy Research Institute of Cardiology of Saratov Medical UniversitySRI of Cardiology of the V. I. Razumovskiy Research Institute of Cardiology of Saratov Medical UniversitySRI of Cardiology of the V. I. Razumovskiy Research Institute of Cardiology of Saratov Medical UniversitySRI of Cardiology of the V. I. Razumovskiy Research Institute of Cardiology of Saratov Medical UniversityAim. To evaluate the dynamics of thrombocyte functional activity (TFA) under antiplatelet treatment conditions which include the branded, and generic compounds as well, in ST elevation acute coronary syndrome patients (STEACS) in routine clinical practice.Material and methods. The open-label prospective study was done, including STEACS patients stratified according to the kind of antiplatelet in-patient treatment (original and/or generics). As an endpoint, we used the surrogate — functional activity of thrombocytes (TFA), measured by impedance and luminescent aggregatometry at 1 and 7 day from STEACS onset.Results. By the inclusion, baseline point all patients were comparable by TFA. On double antiplatelet therapy (DAT) by the 7th day of STEACS there was statistically significant difference of all ADP-induced thrombocyte aggregation. There was difference in ADP-induced platelet aggregation depending on the DAT variant, which included the original drug and generic.Conclusion. In STEACS patients the level of aggregation activity of platelets does significantly differ from the kind of antiplatelet treatment. Usage of the branded and generic compounds of the came antiplatelet agent by the same regimen does differ by different grade and dynamics of platelets activeness suppression.https://russjcardiol.elpub.ru/jour/article/view/567st elevation acute coronary syndromeantiplatelet treatmentfunctional activeness of plateletsgenericsoriginal compound |
| spellingShingle | L. I. Malinova N. V. Furman P. V. Dolotovskaya N. F. Puchinian I. Yu. Radaeva ANTIPLATELET TREATMENT IN ST ELEVATION ACUTE CORONARY SYNDROME UNDER REAL CLINICAL CIRCUMSTANCES: THE DYNAMICS OF THROMBOCYTE FUNCTION Российский кардиологический журнал st elevation acute coronary syndrome antiplatelet treatment functional activeness of platelets generics original compound |
| title | ANTIPLATELET TREATMENT IN ST ELEVATION ACUTE CORONARY SYNDROME UNDER REAL CLINICAL CIRCUMSTANCES: THE DYNAMICS OF THROMBOCYTE FUNCTION |
| title_full | ANTIPLATELET TREATMENT IN ST ELEVATION ACUTE CORONARY SYNDROME UNDER REAL CLINICAL CIRCUMSTANCES: THE DYNAMICS OF THROMBOCYTE FUNCTION |
| title_fullStr | ANTIPLATELET TREATMENT IN ST ELEVATION ACUTE CORONARY SYNDROME UNDER REAL CLINICAL CIRCUMSTANCES: THE DYNAMICS OF THROMBOCYTE FUNCTION |
| title_full_unstemmed | ANTIPLATELET TREATMENT IN ST ELEVATION ACUTE CORONARY SYNDROME UNDER REAL CLINICAL CIRCUMSTANCES: THE DYNAMICS OF THROMBOCYTE FUNCTION |
| title_short | ANTIPLATELET TREATMENT IN ST ELEVATION ACUTE CORONARY SYNDROME UNDER REAL CLINICAL CIRCUMSTANCES: THE DYNAMICS OF THROMBOCYTE FUNCTION |
| title_sort | antiplatelet treatment in st elevation acute coronary syndrome under real clinical circumstances the dynamics of thrombocyte function |
| topic | st elevation acute coronary syndrome antiplatelet treatment functional activeness of platelets generics original compound |
| url | https://russjcardiol.elpub.ru/jour/article/view/567 |
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