Versatile Peptide-Based Nanosystems for Photodynamic Therapy
Photodynamic therapy (PDT) has become an important therapeutic strategy because it is highly controllable, effective, and does not cause drug resistance. Moreover, precise delivery of photosensitizers to tumor lesions can greatly reduce the amount of drug administered and optimize therapeutic outcom...
| Autori principali: | , , , |
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| Natura: | Articolo |
| Lingua: | English |
| Pubblicazione: |
MDPI AG
2024-02-01
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| Serie: | Pharmaceutics |
| Soggetti: | |
| Accesso online: | https://www.mdpi.com/1999-4923/16/2/218 |
| _version_ | 1827342972720513024 |
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| author | Qiuyan Li Ruiqi Ming Lili Huang Ruoyu Zhang |
| author_facet | Qiuyan Li Ruiqi Ming Lili Huang Ruoyu Zhang |
| author_sort | Qiuyan Li |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) has become an important therapeutic strategy because it is highly controllable, effective, and does not cause drug resistance. Moreover, precise delivery of photosensitizers to tumor lesions can greatly reduce the amount of drug administered and optimize therapeutic outcomes. As alternatives to protein antibodies, peptides have been applied as useful targeting ligands for targeted biomedical imaging, drug delivery and PDT. In addition, other functionalities of peptides such as stimuli responsiveness, self-assembly, and therapeutic activity can be integrated with photosensitizers to yield versatile peptide-based nanosystems for PDT. In this article, we start with a brief introduction to PDT and peptide-based nanosystems, followed by more detailed descriptions about the structure, property, and architecture of peptides as background information. Finally, the most recent advances in peptide-based nanosystems for PDT are emphasized and summarized according to the functionalities of peptide in the system to reveal the design and development principle in different therapeutic circumstances. We hope this review could provide useful insights and valuable reference for the development of peptide-based nanosystems for PDT. |
| first_indexed | 2024-03-07T22:18:04Z |
| format | Article |
| id | doaj.art-8b8bdc8ef9374362ae887ee171b08fb1 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-07T22:18:04Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8b8bdc8ef9374362ae887ee171b08fb12024-02-23T15:31:08ZengMDPI AGPharmaceutics1999-49232024-02-0116221810.3390/pharmaceutics16020218Versatile Peptide-Based Nanosystems for Photodynamic TherapyQiuyan Li0Ruiqi Ming1Lili Huang2Ruoyu Zhang3Institute of Engineering Medicine, School of Medical Technology, Beijing Institute of Technology, Beijing 100081, ChinaInstitute of Engineering Medicine, School of Medical Technology, Beijing Institute of Technology, Beijing 100081, ChinaInstitute of Engineering Medicine, School of Medical Technology, Beijing Institute of Technology, Beijing 100081, ChinaInstitute of Engineering Medicine, School of Medical Technology, Beijing Institute of Technology, Beijing 100081, ChinaPhotodynamic therapy (PDT) has become an important therapeutic strategy because it is highly controllable, effective, and does not cause drug resistance. Moreover, precise delivery of photosensitizers to tumor lesions can greatly reduce the amount of drug administered and optimize therapeutic outcomes. As alternatives to protein antibodies, peptides have been applied as useful targeting ligands for targeted biomedical imaging, drug delivery and PDT. In addition, other functionalities of peptides such as stimuli responsiveness, self-assembly, and therapeutic activity can be integrated with photosensitizers to yield versatile peptide-based nanosystems for PDT. In this article, we start with a brief introduction to PDT and peptide-based nanosystems, followed by more detailed descriptions about the structure, property, and architecture of peptides as background information. Finally, the most recent advances in peptide-based nanosystems for PDT are emphasized and summarized according to the functionalities of peptide in the system to reveal the design and development principle in different therapeutic circumstances. We hope this review could provide useful insights and valuable reference for the development of peptide-based nanosystems for PDT.https://www.mdpi.com/1999-4923/16/2/218peptidephotodynamic therapytargetingstimuli-responsiveself-assembly |
| spellingShingle | Qiuyan Li Ruiqi Ming Lili Huang Ruoyu Zhang Versatile Peptide-Based Nanosystems for Photodynamic Therapy Pharmaceutics peptide photodynamic therapy targeting stimuli-responsive self-assembly |
| title | Versatile Peptide-Based Nanosystems for Photodynamic Therapy |
| title_full | Versatile Peptide-Based Nanosystems for Photodynamic Therapy |
| title_fullStr | Versatile Peptide-Based Nanosystems for Photodynamic Therapy |
| title_full_unstemmed | Versatile Peptide-Based Nanosystems for Photodynamic Therapy |
| title_short | Versatile Peptide-Based Nanosystems for Photodynamic Therapy |
| title_sort | versatile peptide based nanosystems for photodynamic therapy |
| topic | peptide photodynamic therapy targeting stimuli-responsive self-assembly |
| url | https://www.mdpi.com/1999-4923/16/2/218 |
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