COVID-19 Infection in Heart Transplant Recipients: Results of a Six-Month Prospective Survey-Based Study
Solid-organ transplantation recipients were assumed highly vulnerable to coronavirus disease 2019 (COVID-19). However, the results of previous studies in patients with orthotopic heart transplantation (OHT) under immunosuppressive therapy are contradictory. Therefore, we aimed to assess the prevale...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2022-07-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/9883 |
| _version_ | 1818477699377659904 |
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| author | Vahideh Lalehfar Farnoosh Larti Ali Mehrakizadeh Alireza Bakhshandeh Roya Sattarzadeh Badkoubeh Shabnam Mohammadzadeh Akram Sardari |
| author_facet | Vahideh Lalehfar Farnoosh Larti Ali Mehrakizadeh Alireza Bakhshandeh Roya Sattarzadeh Badkoubeh Shabnam Mohammadzadeh Akram Sardari |
| author_sort | Vahideh Lalehfar |
| collection | DOAJ |
| description |
Solid-organ transplantation recipients were assumed highly vulnerable to coronavirus disease 2019 (COVID-19). However, the results of previous studies in patients with orthotopic heart transplantation (OHT) under immunosuppressive therapy are contradictory. Therefore, we aimed to assess the prevalence of COVID-19 infection and associated risk factors, along with the six-month outcomes in COVID-19 positive OHT patients. This single-center telephone-based survey was conducted on OHT patients. Using a detailed questionnaire, exposure to COVID-19, related symptoms, and preventive self-care measures were collected. Outcomes of COVID-19-positive patients were reassessed using another survey six months later. 118 OHT patients (male: n=87, 73.7%) were included with a mean age of 45.3±13.1 years. Sixteen patients (13.5%) reported one or more symptoms compatible with COVID-19, of whom 12 (10.2%) tested positive. Our results indicated no statistically significant association between COVID-19 and comorbidities. Poor adherence to self-care measures and contact with positive index cases were both significantly associated with COVID-19 infection (P<0.001). A later six months follow-up showed that two out of 12 (16.6%) COVID-19 positive OHT patients died. There was no statistically significant difference between the prevalence of COVID-19 in our patients compared to Iran’s general population (P=0.152). Non-compliance with personal protective protocols and a history of contact with COVID-19 cases were the most risk factors for COVID-19 infection in OHT patients.
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| first_indexed | 2024-12-10T09:40:25Z |
| format | Article |
| id | doaj.art-8b8d5bf6f9714fde8847c67545c5b9a9 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-10T09:40:25Z |
| publishDate | 2022-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-8b8d5bf6f9714fde8847c67545c5b9a92022-12-22T01:54:01ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942022-07-0160610.18502/acta.v60i6.10037COVID-19 Infection in Heart Transplant Recipients: Results of a Six-Month Prospective Survey-Based StudyVahideh Lalehfar0Farnoosh Larti1Ali Mehrakizadeh2Alireza Bakhshandeh3Roya Sattarzadeh Badkoubeh4Shabnam Mohammadzadeh5Akram Sardari6Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of cardiovascular surgeryl, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Solid-organ transplantation recipients were assumed highly vulnerable to coronavirus disease 2019 (COVID-19). However, the results of previous studies in patients with orthotopic heart transplantation (OHT) under immunosuppressive therapy are contradictory. Therefore, we aimed to assess the prevalence of COVID-19 infection and associated risk factors, along with the six-month outcomes in COVID-19 positive OHT patients. This single-center telephone-based survey was conducted on OHT patients. Using a detailed questionnaire, exposure to COVID-19, related symptoms, and preventive self-care measures were collected. Outcomes of COVID-19-positive patients were reassessed using another survey six months later. 118 OHT patients (male: n=87, 73.7%) were included with a mean age of 45.3±13.1 years. Sixteen patients (13.5%) reported one or more symptoms compatible with COVID-19, of whom 12 (10.2%) tested positive. Our results indicated no statistically significant association between COVID-19 and comorbidities. Poor adherence to self-care measures and contact with positive index cases were both significantly associated with COVID-19 infection (P<0.001). A later six months follow-up showed that two out of 12 (16.6%) COVID-19 positive OHT patients died. There was no statistically significant difference between the prevalence of COVID-19 in our patients compared to Iran’s general population (P=0.152). Non-compliance with personal protective protocols and a history of contact with COVID-19 cases were the most risk factors for COVID-19 infection in OHT patients. https://acta.tums.ac.ir/index.php/acta/article/view/9883Coronavirus disease 2019 (COVID-19)Heart transplantationImmunosuppressionPreventive self-care measuresTelephone-based survey |
| spellingShingle | Vahideh Lalehfar Farnoosh Larti Ali Mehrakizadeh Alireza Bakhshandeh Roya Sattarzadeh Badkoubeh Shabnam Mohammadzadeh Akram Sardari COVID-19 Infection in Heart Transplant Recipients: Results of a Six-Month Prospective Survey-Based Study Acta Medica Iranica Coronavirus disease 2019 (COVID-19) Heart transplantation Immunosuppression Preventive self-care measures Telephone-based survey |
| title | COVID-19 Infection in Heart Transplant Recipients: Results of a Six-Month Prospective Survey-Based Study |
| title_full | COVID-19 Infection in Heart Transplant Recipients: Results of a Six-Month Prospective Survey-Based Study |
| title_fullStr | COVID-19 Infection in Heart Transplant Recipients: Results of a Six-Month Prospective Survey-Based Study |
| title_full_unstemmed | COVID-19 Infection in Heart Transplant Recipients: Results of a Six-Month Prospective Survey-Based Study |
| title_short | COVID-19 Infection in Heart Transplant Recipients: Results of a Six-Month Prospective Survey-Based Study |
| title_sort | covid 19 infection in heart transplant recipients results of a six month prospective survey based study |
| topic | Coronavirus disease 2019 (COVID-19) Heart transplantation Immunosuppression Preventive self-care measures Telephone-based survey |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/9883 |
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