Multi-Scale FC-Based Multi-Order GCN: A Novel Model for Predicting Individual Behavior From fMRI
Predicting individual behavior from brain imaging data using machine learning is a rapidly growing field in neuroscience. Functional connectivity (FC), which captures interactions between different brain regions, contains valuable information about the organization of the brain and is considered a c...
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| Format: | Article |
| Language: | English |
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IEEE
2024-01-01
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| Series: | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/10411915/ |
| _version_ | 1797339287208853504 |
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| author | Xuyun Wen Qumei Cao Bin Jing Daoqiang Zhang |
| author_facet | Xuyun Wen Qumei Cao Bin Jing Daoqiang Zhang |
| author_sort | Xuyun Wen |
| collection | DOAJ |
| description | Predicting individual behavior from brain imaging data using machine learning is a rapidly growing field in neuroscience. Functional connectivity (FC), which captures interactions between different brain regions, contains valuable information about the organization of the brain and is considered a crucial feature for modeling human behavior. Graph convolutional networks (GCN) have proven to be a powerful tool for extracting graph structure features and have shown promising results in various FC-based classification tasks, such as disease classification and prognosis prediction. Despite this success, few behavior prediction models currently exist based on GCN, and their performance is not satisfactory. To address this gap, a new model called the Multi-Scale FC-based Multi-Order GCN (MSFC-MO-GCN) was proposed in this paper. The model considers the hierarchical structure of the brain system and utilizes FCs inferred from multiple spatial scales as input to comprehensively characterize individual brain organization. To enhance the feature learning ability of GCN, a multi-order graph convolutional layer is incorporated, which uses multi-order neighbors to guide message passing and learns high-order graph information of nodal connections. Additionally, an inter-subject contrast constraint is designed to control the potential information redundancy of FCs among different spatial scales during the feature learning process. Experimental evaluation were conducted on the publicly available dataset from human connectome project. A total of 805 healthy subjects were included and 5 representative behavior metrics were used. The experimental results show that our proposed method outperforms the existing behavior prediction models in all behavior prediction tasks. |
| first_indexed | 2024-03-08T09:43:49Z |
| format | Article |
| id | doaj.art-8b8f1e0b1de54c0492863addbcd72896 |
| institution | Directory Open Access Journal |
| issn | 1558-0210 |
| language | English |
| last_indexed | 2024-03-08T09:43:49Z |
| publishDate | 2024-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| spelling | doaj.art-8b8f1e0b1de54c0492863addbcd728962024-01-30T00:00:17ZengIEEEIEEE Transactions on Neural Systems and Rehabilitation Engineering1558-02102024-01-013254855810.1109/TNSRE.2024.335705910411915Multi-Scale FC-Based Multi-Order GCN: A Novel Model for Predicting Individual Behavior From fMRIXuyun Wen0https://orcid.org/0000-0003-2230-8658Qumei Cao1Bin Jing2https://orcid.org/0000-0002-4478-8683Daoqiang Zhang3https://orcid.org/0000-0003-2230-8658College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, ChinaCollege of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, ChinaSchool of Biomedical Engineering, Capital Medical University, Beijing, ChinaCollege of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, ChinaPredicting individual behavior from brain imaging data using machine learning is a rapidly growing field in neuroscience. Functional connectivity (FC), which captures interactions between different brain regions, contains valuable information about the organization of the brain and is considered a crucial feature for modeling human behavior. Graph convolutional networks (GCN) have proven to be a powerful tool for extracting graph structure features and have shown promising results in various FC-based classification tasks, such as disease classification and prognosis prediction. Despite this success, few behavior prediction models currently exist based on GCN, and their performance is not satisfactory. To address this gap, a new model called the Multi-Scale FC-based Multi-Order GCN (MSFC-MO-GCN) was proposed in this paper. The model considers the hierarchical structure of the brain system and utilizes FCs inferred from multiple spatial scales as input to comprehensively characterize individual brain organization. To enhance the feature learning ability of GCN, a multi-order graph convolutional layer is incorporated, which uses multi-order neighbors to guide message passing and learns high-order graph information of nodal connections. Additionally, an inter-subject contrast constraint is designed to control the potential information redundancy of FCs among different spatial scales during the feature learning process. Experimental evaluation were conducted on the publicly available dataset from human connectome project. A total of 805 healthy subjects were included and 5 representative behavior metrics were used. The experimental results show that our proposed method outperforms the existing behavior prediction models in all behavior prediction tasks.https://ieeexplore.ieee.org/document/10411915/Functional connectivityhuman behaviorgraph convolutional networkmulti-scalemulti-order |
| spellingShingle | Xuyun Wen Qumei Cao Bin Jing Daoqiang Zhang Multi-Scale FC-Based Multi-Order GCN: A Novel Model for Predicting Individual Behavior From fMRI IEEE Transactions on Neural Systems and Rehabilitation Engineering Functional connectivity human behavior graph convolutional network multi-scale multi-order |
| title | Multi-Scale FC-Based Multi-Order GCN: A Novel Model for Predicting Individual Behavior From fMRI |
| title_full | Multi-Scale FC-Based Multi-Order GCN: A Novel Model for Predicting Individual Behavior From fMRI |
| title_fullStr | Multi-Scale FC-Based Multi-Order GCN: A Novel Model for Predicting Individual Behavior From fMRI |
| title_full_unstemmed | Multi-Scale FC-Based Multi-Order GCN: A Novel Model for Predicting Individual Behavior From fMRI |
| title_short | Multi-Scale FC-Based Multi-Order GCN: A Novel Model for Predicting Individual Behavior From fMRI |
| title_sort | multi scale fc based multi order gcn a novel model for predicting individual behavior from fmri |
| topic | Functional connectivity human behavior graph convolutional network multi-scale multi-order |
| url | https://ieeexplore.ieee.org/document/10411915/ |
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