Treatment of iron deficiency in patients after acute decompensation: a new target in the treatment of heart failure
Iron deficiency (ID) is one of the most common comorbidities in patients with heart failure (HF). ID is a strong independent predictor of outcomes in HF patients. ID reduces quality of life, exercise tolerance, and survival in patients with HF, regardless of anemia status. The latest 2021 gui...
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| 格式: | 文件 |
| 语言: | Russian |
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«FIRMA «SILICEA» LLC
2022-06-01
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| 丛编: | Российский кардиологический журнал |
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| 在线阅读: | https://russjcardiol.elpub.ru/jour/article/view/4940 |
| _version_ | 1826561001142616064 |
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| author | I. V. Zhirov N. V. Safronova S. N. Tereshchenko |
| author_facet | I. V. Zhirov N. V. Safronova S. N. Tereshchenko |
| author_sort | I. V. Zhirov |
| collection | DOAJ |
| description | Iron deficiency (ID) is one of the most common comorbidities in patients with heart failure (HF). ID is a strong independent predictor of outcomes in HF patients. ID reduces quality of life, exercise tolerance, and survival in patients with HF, regardless of anemia status. The latest 2021 guidelines recommend initiating ID treatment at a ferritin <100 µg/L, or 100 to 299 µg/L, when transferrin saturation is less than 20%. The FAIR-HF and CONFIRM-HF studies have shown improvements in symptoms, quality of life, and functional status in patients with stable HF and ID after intravenous administration of ferric carboxymaltose (FCM). Moreover, the results of these studies showed a reduced risk of hospitalization for HF, which was later confirmed in a subsequent meta-analysis. Finally, the AFFIRM-AHF study, which evaluated the effect of FCM administration on outcomes in patients hospitalized for acute HF/acute decompensated HF, found a significant reduction in HF-related readmissions among patients treated with FCM. |
| first_indexed | 2024-04-09T20:43:28Z |
| format | Article |
| id | doaj.art-8b8f2eaf7f704e23a9b7979b404f8d4b |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2025-03-14T09:25:14Z |
| publishDate | 2022-06-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-8b8f2eaf7f704e23a9b7979b404f8d4b2025-03-02T11:42:58Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202022-06-01272S10.15829/1560-4071-2022-49493559Treatment of iron deficiency in patients after acute decompensation: a new target in the treatment of heart failureI. V. Zhirov0N. V. Safronova1S. N. Tereshchenko2National Medical Research Center of Cardiology; Russian Medical Academy of Continuous Professional EducationNational Medical Research Center of CardiologyNational Medical Research Center of Cardiology; Russian Medical Academy of Continuous Professional EducationIron deficiency (ID) is one of the most common comorbidities in patients with heart failure (HF). ID is a strong independent predictor of outcomes in HF patients. ID reduces quality of life, exercise tolerance, and survival in patients with HF, regardless of anemia status. The latest 2021 guidelines recommend initiating ID treatment at a ferritin <100 µg/L, or 100 to 299 µg/L, when transferrin saturation is less than 20%. The FAIR-HF and CONFIRM-HF studies have shown improvements in symptoms, quality of life, and functional status in patients with stable HF and ID after intravenous administration of ferric carboxymaltose (FCM). Moreover, the results of these studies showed a reduced risk of hospitalization for HF, which was later confirmed in a subsequent meta-analysis. Finally, the AFFIRM-AHF study, which evaluated the effect of FCM administration on outcomes in patients hospitalized for acute HF/acute decompensated HF, found a significant reduction in HF-related readmissions among patients treated with FCM.https://russjcardiol.elpub.ru/jour/article/view/4940heart failureacute decompensated heart failureiron deficiencyanemiaferric carboxymaltose |
| spellingShingle | I. V. Zhirov N. V. Safronova S. N. Tereshchenko Treatment of iron deficiency in patients after acute decompensation: a new target in the treatment of heart failure Российский кардиологический журнал heart failure acute decompensated heart failure iron deficiency anemia ferric carboxymaltose |
| title | Treatment of iron deficiency in patients after acute decompensation: a new target in the treatment of heart failure |
| title_full | Treatment of iron deficiency in patients after acute decompensation: a new target in the treatment of heart failure |
| title_fullStr | Treatment of iron deficiency in patients after acute decompensation: a new target in the treatment of heart failure |
| title_full_unstemmed | Treatment of iron deficiency in patients after acute decompensation: a new target in the treatment of heart failure |
| title_short | Treatment of iron deficiency in patients after acute decompensation: a new target in the treatment of heart failure |
| title_sort | treatment of iron deficiency in patients after acute decompensation a new target in the treatment of heart failure |
| topic | heart failure acute decompensated heart failure iron deficiency anemia ferric carboxymaltose |
| url | https://russjcardiol.elpub.ru/jour/article/view/4940 |
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