MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring
Kawasaki disease (KD) is an acute autoimmune vascular disease featured with a long stage of febrile. It predominantly afflicts children under 5 years old and causes an increased risk of cardiovascular combinations. The onset and progression of KD are impacted by many aspects, including genetic susce...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1016575/full |
| _version_ | 1811307761809489920 |
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| author | Yiyi Xiong Jiawei Xu Deju Zhang Shuqin Wu Zhangwang Li Jing Zhang Zhongbin Xia Panpan Xia Cai Xia Xiaoyi Tang Xiao Liu Jianping Liu Jianping Liu Peng Yu Peng Yu |
| author_facet | Yiyi Xiong Jiawei Xu Deju Zhang Shuqin Wu Zhangwang Li Jing Zhang Zhongbin Xia Panpan Xia Cai Xia Xiaoyi Tang Xiao Liu Jianping Liu Jianping Liu Peng Yu Peng Yu |
| author_sort | Yiyi Xiong |
| collection | DOAJ |
| description | Kawasaki disease (KD) is an acute autoimmune vascular disease featured with a long stage of febrile. It predominantly afflicts children under 5 years old and causes an increased risk of cardiovascular combinations. The onset and progression of KD are impacted by many aspects, including genetic susceptibility, infection, and immunity. In recent years, many studies revealed that miRNAs, a novel class of small non-coding RNAs, may play an indispensable role in the development of KD via differential expression and participation in the central pathogenesis of KD comprise of the modulation of immunity, inflammatory response and vascular dysregulation. Although specific diagnose criteria remains unclear up to date, accumulating clinical evidence indicated that miRNAs, as small molecules, could serve as potential diagnostic biomarkers and exhibit extraordinary specificity and sensitivity. Besides, miRNAs have gained attention in affecting therapies for Kawasaki disease and providing new insights into personalized treatment. Through consanguineous coordination with classical therapies, miRNAs could overcome the inevitable drug-resistance and poor prognosis problem in a novel point of view. In this review, we systematically reviewed the existing literature and summarized those findings to analyze the latest mechanism to explore the role of miRNAs in the treatment of KD from basic and clinical aspects retrospectively. Our discussion helps to better understand the pathogenesis of KD and may offer profound inspiration on KD diagnosis, treatment, and prognosis. |
| first_indexed | 2024-04-13T09:11:28Z |
| format | Article |
| id | doaj.art-8b900ab4b9a446089df5e0f2fdf1cd2f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T09:11:28Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8b900ab4b9a446089df5e0f2fdf1cd2f2022-12-22T02:52:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.10165751016575MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoringYiyi Xiong0Jiawei Xu1Deju Zhang2Shuqin Wu3Zhangwang Li4Jing Zhang5Zhongbin Xia6Panpan Xia7Cai Xia8Xiaoyi Tang9Xiao Liu10Jianping Liu11Jianping Liu12Peng Yu13Peng Yu14The Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaThe Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaFood and Nutritional Sciences, School of Biological Sciences, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaThe Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaThe Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaThe Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaThe Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaThe Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaKawasaki disease (KD) is an acute autoimmune vascular disease featured with a long stage of febrile. It predominantly afflicts children under 5 years old and causes an increased risk of cardiovascular combinations. The onset and progression of KD are impacted by many aspects, including genetic susceptibility, infection, and immunity. In recent years, many studies revealed that miRNAs, a novel class of small non-coding RNAs, may play an indispensable role in the development of KD via differential expression and participation in the central pathogenesis of KD comprise of the modulation of immunity, inflammatory response and vascular dysregulation. Although specific diagnose criteria remains unclear up to date, accumulating clinical evidence indicated that miRNAs, as small molecules, could serve as potential diagnostic biomarkers and exhibit extraordinary specificity and sensitivity. Besides, miRNAs have gained attention in affecting therapies for Kawasaki disease and providing new insights into personalized treatment. Through consanguineous coordination with classical therapies, miRNAs could overcome the inevitable drug-resistance and poor prognosis problem in a novel point of view. In this review, we systematically reviewed the existing literature and summarized those findings to analyze the latest mechanism to explore the role of miRNAs in the treatment of KD from basic and clinical aspects retrospectively. Our discussion helps to better understand the pathogenesis of KD and may offer profound inspiration on KD diagnosis, treatment, and prognosis.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1016575/fullKawasaki diseasemicriRNAsbiomarkertherapeutic targetprognosis |
| spellingShingle | Yiyi Xiong Jiawei Xu Deju Zhang Shuqin Wu Zhangwang Li Jing Zhang Zhongbin Xia Panpan Xia Cai Xia Xiaoyi Tang Xiao Liu Jianping Liu Jianping Liu Peng Yu Peng Yu MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring Frontiers in Immunology Kawasaki disease micriRNAs biomarker therapeutic target prognosis |
| title | MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring |
| title_full | MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring |
| title_fullStr | MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring |
| title_full_unstemmed | MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring |
| title_short | MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring |
| title_sort | micrornas in kawasaki disease an update on diagnosis therapy and monitoring |
| topic | Kawasaki disease micriRNAs biomarker therapeutic target prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1016575/full |
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