Varicella vaccination - the global experience
Introduction: Varicella, although a frequently benign childhood disease, nevertheless represents a considerable health burden. WHO recommends including varicella vaccines in universal routine vaccination programs, and maintaining coverage >80%. Many countries have successfully introduced varicell...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-08-01
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| Series: | Expert Review of Vaccines |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14760584.2017.1343669 |
| _version_ | 1827813251282370560 |
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| author | Peter Wutzler Paolo Bonanni Margaret Burgess Anne Gershon Marco Aurélio Sáfadi Giacomo Casabona |
| author_facet | Peter Wutzler Paolo Bonanni Margaret Burgess Anne Gershon Marco Aurélio Sáfadi Giacomo Casabona |
| author_sort | Peter Wutzler |
| collection | DOAJ |
| description | Introduction: Varicella, although a frequently benign childhood disease, nevertheless represents a considerable health burden. WHO recommends including varicella vaccines in universal routine vaccination programs, and maintaining coverage >80%. Many countries have successfully introduced varicella vaccination and have benefited from lower disease burden, but many others have not adopted the vaccine. Reasons include cost commitment for a ‘mild childhood disease’ or concerns that vaccination will shift varicella to older age groups or increase herpes zoster incidence. Areas covered: This literature review summarizes the effectiveness and epidemiological impact of varicella immunization programs. Expert commentary: Varicella vaccines are immunogenic with acceptable safety profiles. One and two dose schedules are highly effective against varicella and large reductions in disease incidence, particularly moderate-severe disease, have been widely reported. There is currently no evidence to suggest that the introduction of varicella vaccination results in a shift of varicella disease burden to older age groups. Although epidemiological studies have shown an increased incidence of herpes zoster since the vaccines were launched, there are many other contributing factors, and indeed, this secular trend was evident before their introduction. In conclusion, varicella vaccination easily fits into existing immunization programs and significantly reduces the often underestimated burden of varicella. |
| first_indexed | 2024-03-11T23:29:55Z |
| format | Article |
| id | doaj.art-8b9083b8b13149d69482f65bfcc2ef6b |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:29:55Z |
| publishDate | 2017-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-8b9083b8b13149d69482f65bfcc2ef6b2023-09-20T10:18:02ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952017-08-0116883384310.1080/14760584.2017.13436691343669Varicella vaccination - the global experiencePeter Wutzler0Paolo Bonanni1Margaret Burgess2Anne Gershon3Marco Aurélio Sáfadi4Giacomo Casabona5Friedrich Schiller UniversityUniversity of FlorenceUniversity of SydneyColumbia UniversitySanta Casa de Sao Paulo School of Medical SciencesGlobal Medical Affairs Rota & MMRV, GSKIntroduction: Varicella, although a frequently benign childhood disease, nevertheless represents a considerable health burden. WHO recommends including varicella vaccines in universal routine vaccination programs, and maintaining coverage >80%. Many countries have successfully introduced varicella vaccination and have benefited from lower disease burden, but many others have not adopted the vaccine. Reasons include cost commitment for a ‘mild childhood disease’ or concerns that vaccination will shift varicella to older age groups or increase herpes zoster incidence. Areas covered: This literature review summarizes the effectiveness and epidemiological impact of varicella immunization programs. Expert commentary: Varicella vaccines are immunogenic with acceptable safety profiles. One and two dose schedules are highly effective against varicella and large reductions in disease incidence, particularly moderate-severe disease, have been widely reported. There is currently no evidence to suggest that the introduction of varicella vaccination results in a shift of varicella disease burden to older age groups. Although epidemiological studies have shown an increased incidence of herpes zoster since the vaccines were launched, there are many other contributing factors, and indeed, this secular trend was evident before their introduction. In conclusion, varicella vaccination easily fits into existing immunization programs and significantly reduces the often underestimated burden of varicella.http://dx.doi.org/10.1080/14760584.2017.1343669varicellaherpes zostervaccineseffectivenessimmunization |
| spellingShingle | Peter Wutzler Paolo Bonanni Margaret Burgess Anne Gershon Marco Aurélio Sáfadi Giacomo Casabona Varicella vaccination - the global experience Expert Review of Vaccines varicella herpes zoster vaccines effectiveness immunization |
| title | Varicella vaccination - the global experience |
| title_full | Varicella vaccination - the global experience |
| title_fullStr | Varicella vaccination - the global experience |
| title_full_unstemmed | Varicella vaccination - the global experience |
| title_short | Varicella vaccination - the global experience |
| title_sort | varicella vaccination the global experience |
| topic | varicella herpes zoster vaccines effectiveness immunization |
| url | http://dx.doi.org/10.1080/14760584.2017.1343669 |
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