The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia
A growing body of evidence confirms abnormal fatty acid (FAs) metabolism in the pathophysiology of schizophrenia. Omega-3 polyunsaturated fatty acids (PUFAs) are endogenous ligands of the G protein-coupled receptors, which have anti-inflammatory properties and are a therapeutic target in many diseas...
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MDPI AG
2020-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/8/243 |
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| author | Joanna Rog Anna Błażewicz Dariusz Juchnowicz Agnieszka Ludwiczuk Ewa Stelmach Małgorzata Kozioł Michal Karakula Przemysław Niziński Hanna Karakula-Juchnowicz |
| author_facet | Joanna Rog Anna Błażewicz Dariusz Juchnowicz Agnieszka Ludwiczuk Ewa Stelmach Małgorzata Kozioł Michal Karakula Przemysław Niziński Hanna Karakula-Juchnowicz |
| author_sort | Joanna Rog |
| collection | DOAJ |
| description | A growing body of evidence confirms abnormal fatty acid (FAs) metabolism in the pathophysiology of schizophrenia. Omega-3 polyunsaturated fatty acids (PUFAs) are endogenous ligands of the G protein-coupled receptors, which have anti-inflammatory properties and are a therapeutic target in many diseases. No clinical studies are concerned with the role of the GPR120 signaling pathway in schizophrenia. The aim of the study was to determine the differences in PUFA nutritional status and metabolism between patients with schizophrenia (SZ group) and healthy individuals (HC group). The study included 80 participants (40 in the SZ group, 40 in the HC group). There were no differences in serum GPR120 and PUFA concentrations and PUFA intake between the examined groups. In the HC group, there was a relationship between FAs in serum and GPR120 concentration (<i>p</i> < 0.05): α-linolenic acid (ALA) (<i>R</i> = −0.46), docosahexaenoic acid (DHA) (<i>R</i> = −0.54), omega-3 PUFAs (<i>R</i> = −0.41), arachidonic acid (AA) (<i>R</i> = −0.44). In the SZ group, FA serum concentration was not related to GPR120 (<i>p</i> > 0.05). In the HC group, ALA and DHA serum concentrations were independently associated with GPR120 (<i>p</i> < 0.05) in the model adjusted for eicosapentaenoic acid (EPA) and accounted for 38.59% of GPR120 variability (<i>p</i> < 0.05). Our results indicate different metabolisms of FAs in schizophrenia. It is possible that the diminished anti-inflammatory response could be a component connecting GPR120 insensitivity with schizophrenia. |
| first_indexed | 2024-03-10T18:15:07Z |
| format | Article |
| id | doaj.art-8b9102c3d3194a2d86ef3fdf2076e98a |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T18:15:07Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj.art-8b9102c3d3194a2d86ef3fdf2076e98a2023-11-20T07:47:08ZengMDPI AGBiomedicines2227-90592020-07-018824310.3390/biomedicines8080243The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in SchizophreniaJoanna Rog0Anna Błażewicz1Dariusz Juchnowicz2Agnieszka Ludwiczuk3Ewa Stelmach4Małgorzata Kozioł5Michal Karakula6Przemysław Niziński7Hanna Karakula-Juchnowicz81st Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, 20-439 Lublin, PolandChair of Chemistry, Department of Analytical Chemistry, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Psychiatric Nursing, Medical University of Lublin, 20-093 Lublin, PolandIndependent Laboratory of Natural Products Chemistry, Department of Pharmacognosy, Medical University of Lublin, 20-093 Lublin, Poland2nd Department of Psychiatry and Psychiatric Rehabilitation, Medical University of Lublin, 20-439 Lublin, PolandChair and Department of Medical Microbiology, Medical University of Lublin; 20-093 Lublin, PolandStudent Research Team from Department of Analytical Chemistry, Medical University of Lublin, 20-093 Lublin, PolandChair of Chemistry, Department of Analytical Chemistry, Medical University of Lublin, 20-093 Lublin, Poland1st Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, 20-439 Lublin, PolandA growing body of evidence confirms abnormal fatty acid (FAs) metabolism in the pathophysiology of schizophrenia. Omega-3 polyunsaturated fatty acids (PUFAs) are endogenous ligands of the G protein-coupled receptors, which have anti-inflammatory properties and are a therapeutic target in many diseases. No clinical studies are concerned with the role of the GPR120 signaling pathway in schizophrenia. The aim of the study was to determine the differences in PUFA nutritional status and metabolism between patients with schizophrenia (SZ group) and healthy individuals (HC group). The study included 80 participants (40 in the SZ group, 40 in the HC group). There were no differences in serum GPR120 and PUFA concentrations and PUFA intake between the examined groups. In the HC group, there was a relationship between FAs in serum and GPR120 concentration (<i>p</i> < 0.05): α-linolenic acid (ALA) (<i>R</i> = −0.46), docosahexaenoic acid (DHA) (<i>R</i> = −0.54), omega-3 PUFAs (<i>R</i> = −0.41), arachidonic acid (AA) (<i>R</i> = −0.44). In the SZ group, FA serum concentration was not related to GPR120 (<i>p</i> > 0.05). In the HC group, ALA and DHA serum concentrations were independently associated with GPR120 (<i>p</i> < 0.05) in the model adjusted for eicosapentaenoic acid (EPA) and accounted for 38.59% of GPR120 variability (<i>p</i> < 0.05). Our results indicate different metabolisms of FAs in schizophrenia. It is possible that the diminished anti-inflammatory response could be a component connecting GPR120 insensitivity with schizophrenia.https://www.mdpi.com/2227-9059/8/8/243G protein-coupled receptorsGPR120FFAR4schizophreniapolyunsaturated fatty acidslong-chain fatty acids |
| spellingShingle | Joanna Rog Anna Błażewicz Dariusz Juchnowicz Agnieszka Ludwiczuk Ewa Stelmach Małgorzata Kozioł Michal Karakula Przemysław Niziński Hanna Karakula-Juchnowicz The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia Biomedicines G protein-coupled receptors GPR120 FFAR4 schizophrenia polyunsaturated fatty acids long-chain fatty acids |
| title | The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia |
| title_full | The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia |
| title_fullStr | The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia |
| title_full_unstemmed | The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia |
| title_short | The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia |
| title_sort | role of gpr120 receptor in essential fatty acids metabolism in schizophrenia |
| topic | G protein-coupled receptors GPR120 FFAR4 schizophrenia polyunsaturated fatty acids long-chain fatty acids |
| url | https://www.mdpi.com/2227-9059/8/8/243 |
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