Aquaporin 4-positive neuromyelitis optica spectrum disorder with meningoencephalitis-like onset: A case report
Neuromyelitis optica spectrum disease (NMOSD) is a debilitating autoimmune inflammatory demyelinating disease of the central nervous system. The relationship between harboring an infection and NMOSD is currently unclear and needs further investigation. This article reports meningoencephalitis-like m...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.938492/full |
| _version_ | 1798021082992607232 |
|---|---|
| author | Yi Bu Heng Liu XuDong Qian Fan Sun ChengBo Li Jingzhe Han |
| author_facet | Yi Bu Heng Liu XuDong Qian Fan Sun ChengBo Li Jingzhe Han |
| author_sort | Yi Bu |
| collection | DOAJ |
| description | Neuromyelitis optica spectrum disease (NMOSD) is a debilitating autoimmune inflammatory demyelinating disease of the central nervous system. The relationship between harboring an infection and NMOSD is currently unclear and needs further investigation. This article reports meningoencephalitis-like manifestations, including fever, headache, neck resistance, seizures, and pleocytosis, accompanied by nausea and vomiting, in a patient with serum AQP4 antibody-positive area postrema syndrome (APS). In the presence of aseptic meningitis combined with clinical symptoms such as optic neuritis and myelitis, the possibility of NMOSD diagnosis can be considered. However, for patients with unknown causes, especially combined with aseptic meningitis, a probable differential diagnosis of NMOSD is considered. |
| first_indexed | 2024-04-11T17:08:14Z |
| format | Article |
| id | doaj.art-8b931a943aa54909a163b4045c334d70 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T17:08:14Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8b931a943aa54909a163b4045c334d702022-12-22T04:12:59ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.938492938492Aquaporin 4-positive neuromyelitis optica spectrum disorder with meningoencephalitis-like onset: A case reportYi Bu0Heng Liu1XuDong Qian2Fan Sun3ChengBo Li4Jingzhe Han5Department of Neurology, affiliated Hospital of Chengde Medical University, Chengde, ChinaDepartment of Pain, Hengshui People’s Hospital, Hengshui, ChinaDepartment of Neurology, affiliated Hospital of Chengde Medical University, Chengde, ChinaDepartment of Neurology, affiliated Hospital of Chengde Medical University, Chengde, ChinaDepartment of Neurology, affiliated Hospital of Chengde Medical University, Chengde, ChinaDepartment of Neurology, Hengshui People’s Hospital, Hengshui, ChinaNeuromyelitis optica spectrum disease (NMOSD) is a debilitating autoimmune inflammatory demyelinating disease of the central nervous system. The relationship between harboring an infection and NMOSD is currently unclear and needs further investigation. This article reports meningoencephalitis-like manifestations, including fever, headache, neck resistance, seizures, and pleocytosis, accompanied by nausea and vomiting, in a patient with serum AQP4 antibody-positive area postrema syndrome (APS). In the presence of aseptic meningitis combined with clinical symptoms such as optic neuritis and myelitis, the possibility of NMOSD diagnosis can be considered. However, for patients with unknown causes, especially combined with aseptic meningitis, a probable differential diagnosis of NMOSD is considered.https://www.frontiersin.org/articles/10.3389/fimmu.2022.938492/fullneuromyelitis optica spectrum diseaseaquaporinarea postrema syndromecentral nervous systemautoimmune inflammatory demyelinating disease |
| spellingShingle | Yi Bu Heng Liu XuDong Qian Fan Sun ChengBo Li Jingzhe Han Aquaporin 4-positive neuromyelitis optica spectrum disorder with meningoencephalitis-like onset: A case report Frontiers in Immunology neuromyelitis optica spectrum disease aquaporin area postrema syndrome central nervous system autoimmune inflammatory demyelinating disease |
| title | Aquaporin 4-positive neuromyelitis optica spectrum disorder with meningoencephalitis-like onset: A case report |
| title_full | Aquaporin 4-positive neuromyelitis optica spectrum disorder with meningoencephalitis-like onset: A case report |
| title_fullStr | Aquaporin 4-positive neuromyelitis optica spectrum disorder with meningoencephalitis-like onset: A case report |
| title_full_unstemmed | Aquaporin 4-positive neuromyelitis optica spectrum disorder with meningoencephalitis-like onset: A case report |
| title_short | Aquaporin 4-positive neuromyelitis optica spectrum disorder with meningoencephalitis-like onset: A case report |
| title_sort | aquaporin 4 positive neuromyelitis optica spectrum disorder with meningoencephalitis like onset a case report |
| topic | neuromyelitis optica spectrum disease aquaporin area postrema syndrome central nervous system autoimmune inflammatory demyelinating disease |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.938492/full |
| work_keys_str_mv | AT yibu aquaporin4positiveneuromyelitisopticaspectrumdisorderwithmeningoencephalitislikeonsetacasereport AT hengliu aquaporin4positiveneuromyelitisopticaspectrumdisorderwithmeningoencephalitislikeonsetacasereport AT xudongqian aquaporin4positiveneuromyelitisopticaspectrumdisorderwithmeningoencephalitislikeonsetacasereport AT fansun aquaporin4positiveneuromyelitisopticaspectrumdisorderwithmeningoencephalitislikeonsetacasereport AT chengboli aquaporin4positiveneuromyelitisopticaspectrumdisorderwithmeningoencephalitislikeonsetacasereport AT jingzhehan aquaporin4positiveneuromyelitisopticaspectrumdisorderwithmeningoencephalitislikeonsetacasereport |