Dual-sensitive and highly biocompatible O-carboxymethyl chitosan nanodroplets for prostate tumor ultrasonic imaging and treatment
Abstract Nanosized drug delivery systems have rapidly emerged as a promising approach to tumor therapy, which still have many challenges in clinical application. In this study, doxorubicin-loaded O-carboxymethyl chitosan/perfluorohexane nanodroplets (O-CS-DOX NDs) were synthesized and functionally t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-03-01
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| Series: | Cancer Nanotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12645-023-00172-z |
| _version_ | 1797865545807167488 |
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| author | Dong Meng Lu Guo Dandan Shi Xiao Sun Mengmeng Shang Shan Xiao Xiaoying Zhou Yading Zhao Xiaoxuan Wang Jie Li |
| author_facet | Dong Meng Lu Guo Dandan Shi Xiao Sun Mengmeng Shang Shan Xiao Xiaoying Zhou Yading Zhao Xiaoxuan Wang Jie Li |
| author_sort | Dong Meng |
| collection | DOAJ |
| description | Abstract Nanosized drug delivery systems have rapidly emerged as a promising approach to tumor therapy, which still have many challenges in clinical application. In this study, doxorubicin-loaded O-carboxymethyl chitosan/perfluorohexane nanodroplets (O-CS-DOX NDs) were synthesized and functionally tested as an effective drug delivery system in vitro and in vivo. O-CS-DOX NDs with small size (159.6 nm) and good doxorubicin encapsuling ability showed pH- and ultrasound-dependent drug release profile and satisfying ultrasound imaging performance. With high biocompatibility and biosafety, these nanodroplets could accumulate in the tumor sites and exhibit high efficiency in inhibiting tumor growth with ultrasound irradiation. These stable, safe and smart O-CS-DOX NDs showed promising potential as a smart dual-responsive bomb for tumor ultrasonic imaging and treatment. |
| first_indexed | 2024-04-09T23:10:54Z |
| format | Article |
| id | doaj.art-8b943c7c41bb465a8080dd79872e0ece |
| institution | Directory Open Access Journal |
| issn | 1868-6958 1868-6966 |
| language | English |
| last_indexed | 2024-04-09T23:10:54Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Nanotechnology |
| spelling | doaj.art-8b943c7c41bb465a8080dd79872e0ece2023-03-22T10:25:13ZengBMCCancer Nanotechnology1868-69581868-69662023-03-0114112010.1186/s12645-023-00172-zDual-sensitive and highly biocompatible O-carboxymethyl chitosan nanodroplets for prostate tumor ultrasonic imaging and treatmentDong Meng0Lu Guo1Dandan Shi2Xiao Sun3Mengmeng Shang4Shan Xiao5Xiaoying Zhou6Yading Zhao7Xiaoxuan Wang8Jie Li9Department of Ultrasound, Qilu Hospital of Shandong UniversityDepartment of Ultrasound, Qilu Hospital of Shandong UniversityDepartment of Ultrasound, Qilu Hospital of Shandong UniversityDepartment of Ultrasound, Qilu Hospital of Shandong UniversityDepartment of Ultrasound, Qilu Hospital of Shandong UniversityDepartment of Ultrasound, Qilu Hospital of Shandong UniversityDepartment of Ultrasound, Qilu Hospital of Shandong UniversityDepartment of Ultrasound, Qilu Hospital of Shandong UniversityDepartment of Ultrasound, Qilu Hospital of Shandong UniversityDepartment of Ultrasound, Qilu Hospital of Shandong UniversityAbstract Nanosized drug delivery systems have rapidly emerged as a promising approach to tumor therapy, which still have many challenges in clinical application. In this study, doxorubicin-loaded O-carboxymethyl chitosan/perfluorohexane nanodroplets (O-CS-DOX NDs) were synthesized and functionally tested as an effective drug delivery system in vitro and in vivo. O-CS-DOX NDs with small size (159.6 nm) and good doxorubicin encapsuling ability showed pH- and ultrasound-dependent drug release profile and satisfying ultrasound imaging performance. With high biocompatibility and biosafety, these nanodroplets could accumulate in the tumor sites and exhibit high efficiency in inhibiting tumor growth with ultrasound irradiation. These stable, safe and smart O-CS-DOX NDs showed promising potential as a smart dual-responsive bomb for tumor ultrasonic imaging and treatment.https://doi.org/10.1186/s12645-023-00172-zO-carboxymethyl chitosanNanodropletspH-sensitiveHigh biocompatibilityUltrasound-sensitiveUltrasound imaging |
| spellingShingle | Dong Meng Lu Guo Dandan Shi Xiao Sun Mengmeng Shang Shan Xiao Xiaoying Zhou Yading Zhao Xiaoxuan Wang Jie Li Dual-sensitive and highly biocompatible O-carboxymethyl chitosan nanodroplets for prostate tumor ultrasonic imaging and treatment Cancer Nanotechnology O-carboxymethyl chitosan Nanodroplets pH-sensitive High biocompatibility Ultrasound-sensitive Ultrasound imaging |
| title | Dual-sensitive and highly biocompatible O-carboxymethyl chitosan nanodroplets for prostate tumor ultrasonic imaging and treatment |
| title_full | Dual-sensitive and highly biocompatible O-carboxymethyl chitosan nanodroplets for prostate tumor ultrasonic imaging and treatment |
| title_fullStr | Dual-sensitive and highly biocompatible O-carboxymethyl chitosan nanodroplets for prostate tumor ultrasonic imaging and treatment |
| title_full_unstemmed | Dual-sensitive and highly biocompatible O-carboxymethyl chitosan nanodroplets for prostate tumor ultrasonic imaging and treatment |
| title_short | Dual-sensitive and highly biocompatible O-carboxymethyl chitosan nanodroplets for prostate tumor ultrasonic imaging and treatment |
| title_sort | dual sensitive and highly biocompatible o carboxymethyl chitosan nanodroplets for prostate tumor ultrasonic imaging and treatment |
| topic | O-carboxymethyl chitosan Nanodroplets pH-sensitive High biocompatibility Ultrasound-sensitive Ultrasound imaging |
| url | https://doi.org/10.1186/s12645-023-00172-z |
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