FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses

FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses mediates host cell entry and is S-acylated on multiple phylogenetically conserved cysteine residues. Multiple protein acyltransferase enzymes have been reported to post-translationally modify sp...

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Bibliographic Details
Main Authors: Katrina Mekhail, Minhyoung Lee, Michael Sugiyama, Audrey Astori, Jonathan St-Germain, Elyse Latreille, Negar Khosraviani, Kuiru Wei, Zhijie Li, James Rini, Warren L. Lee, Costin Antonescu, Brian Raught, Gregory D. Fairn
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Journal of Lipid Research
Subjects:
S-acylation
ZDHHC
spike coronavirus
click chemistry
FASN
palmitate
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752200089X

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