Influence of Helicobacter pylori infection on risk of rheumatoid arthritis: a nationwide population-based study
Abstract The relationship between Helicobacter pylori infection and rheumatoid arthritis has been investigated, but the results remain controversial. This study aims to determine the association between the two diseases via a 17-year retrospective cohort study. Using the National Health Insurance Re...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-42207-w |
| _version_ | 1797576710040846336 |
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| author | Tzu-Hsuan Lee Meng-Che Wu Ming-Hung Lee Pei-Lun Liao Chieh-Chung Lin James Cheng-Chung Wei |
| author_facet | Tzu-Hsuan Lee Meng-Che Wu Ming-Hung Lee Pei-Lun Liao Chieh-Chung Lin James Cheng-Chung Wei |
| author_sort | Tzu-Hsuan Lee |
| collection | DOAJ |
| description | Abstract The relationship between Helicobacter pylori infection and rheumatoid arthritis has been investigated, but the results remain controversial. This study aims to determine the association between the two diseases via a 17-year retrospective cohort study. Using the National Health Insurance Research Database, a nationwide population based in Taiwan, we identified 97,533 individuals with H. pylori infection and matched controls between 2000 and 2017 using propensity score matching at a 1:1 ratio. The adjusted hazard ratio of rheumatoid arthritis was determined by multiple Cox regression. The incidence rate of rheumatoid arthritis was 1.28 per 10,000 person-months in the H. pylori cohort, with a higher risk compared to the control group. In the < 30 years old subgroup, the risk was highest, especially in women < 30 years old with H. pylori infection. Patients with < 1 year follow-up showed 1.58 times higher susceptibility to rheumatoid arthritis. Individuals with follow-ups of 1–5 years and over 5 years demonstrated 1.43 and 1.44 times higher risks of rheumatoid arthritis, respectively. Our study showed H. pylori infection was associated with the development of rheumatoid arthritis. Clinicians should note higher risk, especially < 30 years old. More research needed to understand underlying mechanism. |
| first_indexed | 2024-03-10T21:57:36Z |
| format | Article |
| id | doaj.art-8b95c230040643339c44a76b6249c5a2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T21:57:36Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8b95c230040643339c44a76b6249c5a22023-11-19T13:05:01ZengNature PortfolioScientific Reports2045-23222023-09-0113111110.1038/s41598-023-42207-wInfluence of Helicobacter pylori infection on risk of rheumatoid arthritis: a nationwide population-based studyTzu-Hsuan Lee0Meng-Che Wu1Ming-Hung Lee2Pei-Lun Liao3Chieh-Chung Lin4James Cheng-Chung Wei5Division of Gastroenterology, Children’s Medical Center, Taichung Veterans General HospitalDivision of Gastroenterology, Children’s Medical Center, Taichung Veterans General HospitalDepartment of Otolaryngology-Head & Neck Surgery, Taichung Veterans General HospitalDepartment of Medical Research, Chung Shan Medical University HospitalDivision of Gastroenterology, Children’s Medical Center, Taichung Veterans General HospitalInstitute of Medicine, Chung Shan Medical UniversityAbstract The relationship between Helicobacter pylori infection and rheumatoid arthritis has been investigated, but the results remain controversial. This study aims to determine the association between the two diseases via a 17-year retrospective cohort study. Using the National Health Insurance Research Database, a nationwide population based in Taiwan, we identified 97,533 individuals with H. pylori infection and matched controls between 2000 and 2017 using propensity score matching at a 1:1 ratio. The adjusted hazard ratio of rheumatoid arthritis was determined by multiple Cox regression. The incidence rate of rheumatoid arthritis was 1.28 per 10,000 person-months in the H. pylori cohort, with a higher risk compared to the control group. In the < 30 years old subgroup, the risk was highest, especially in women < 30 years old with H. pylori infection. Patients with < 1 year follow-up showed 1.58 times higher susceptibility to rheumatoid arthritis. Individuals with follow-ups of 1–5 years and over 5 years demonstrated 1.43 and 1.44 times higher risks of rheumatoid arthritis, respectively. Our study showed H. pylori infection was associated with the development of rheumatoid arthritis. Clinicians should note higher risk, especially < 30 years old. More research needed to understand underlying mechanism.https://doi.org/10.1038/s41598-023-42207-w |
| spellingShingle | Tzu-Hsuan Lee Meng-Che Wu Ming-Hung Lee Pei-Lun Liao Chieh-Chung Lin James Cheng-Chung Wei Influence of Helicobacter pylori infection on risk of rheumatoid arthritis: a nationwide population-based study Scientific Reports |
| title | Influence of Helicobacter pylori infection on risk of rheumatoid arthritis: a nationwide population-based study |
| title_full | Influence of Helicobacter pylori infection on risk of rheumatoid arthritis: a nationwide population-based study |
| title_fullStr | Influence of Helicobacter pylori infection on risk of rheumatoid arthritis: a nationwide population-based study |
| title_full_unstemmed | Influence of Helicobacter pylori infection on risk of rheumatoid arthritis: a nationwide population-based study |
| title_short | Influence of Helicobacter pylori infection on risk of rheumatoid arthritis: a nationwide population-based study |
| title_sort | influence of helicobacter pylori infection on risk of rheumatoid arthritis a nationwide population based study |
| url | https://doi.org/10.1038/s41598-023-42207-w |
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