Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans
The aim of the present study was to study the associations between urine albumin excretion, and a large number of urinary chemokines, cytokines, and growth factors in a normal population. We selected 90 urine samples from individuals without CVD, diabetes, stroke or kidney disease belonging to the P...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/3/396 |
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| author | Bengt Fellström Johanna Helmersson-Karlqvist Lars Lind Inga Soveri Måns Thulin Johan Ärnlöv Kim Kultima Anders Larsson |
| author_facet | Bengt Fellström Johanna Helmersson-Karlqvist Lars Lind Inga Soveri Måns Thulin Johan Ärnlöv Kim Kultima Anders Larsson |
| author_sort | Bengt Fellström |
| collection | DOAJ |
| description | The aim of the present study was to study the associations between urine albumin excretion, and a large number of urinary chemokines, cytokines, and growth factors in a normal population. We selected 90 urine samples from individuals without CVD, diabetes, stroke or kidney disease belonging to the Prospective Investigation of the Vasculature in Uppsala Seniors Study (41 males and 49 females, all aged 75 years). Urinary cytokine levels were analyzed with two multiplex assays (proximity extension assays) and the cytokine levels were correlated with urine albumin. After adjustment for sex, body mass index (BMI), estimated glomerular filtration rate (eGFR), smoking and multiplicity testing, 11 biomarkers remained significantly associated with urine albumin: thrombospondin 2, interleukin 6, interleukin 8, hepatocyte growth factor, matrix metalloproteinase-12 (MMP-12), C-X-C motif chemokine 9, tumor necrosis factor receptor superfamily member 11B, osteoprotegerin, growth-regulated alpha protein, C-X-C motif chemokine 6, oncostatin-M (OSM) and fatty acid-binding protein, intestinal, despite large differences in molecular weights. In this study, we found associations between urinary albumin and both small and large urine proteins. Additional studies are warranted to identify cytokine patterns and potential progression markers in various renal diseases. |
| first_indexed | 2024-03-09T05:01:15Z |
| format | Article |
| id | doaj.art-8b969fd699d949bba0539f23d067c9e6 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T05:01:15Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-8b969fd699d949bba0539f23d067c9e62023-12-03T12:59:47ZengMDPI AGBiomolecules2218-273X2021-03-0111339610.3390/biom11030396Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in HumansBengt Fellström0Johanna Helmersson-Karlqvist1Lars Lind2Inga Soveri3Måns Thulin4Johan Ärnlöv5Kim Kultima6Anders Larsson7Department of Medical Sciences, Uppsala University, Uppsala University Hospital, SE-751 85 Uppsala, SwedenDepartment of Medical Sciences, Uppsala University, Uppsala University Hospital, SE-751 85 Uppsala, SwedenDepartment of Medical Sciences, Uppsala University, Uppsala University Hospital, SE-751 85 Uppsala, SwedenDepartment of Medical Sciences, Uppsala University, Uppsala University Hospital, SE-751 85 Uppsala, SwedenCentre for Statistics, The Swedish University of Agricultural Sciences, SE-752 36 Uppsala, SwedenDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, 14152 Huddinge, SwedenDepartment of Medical Sciences, Uppsala University, Uppsala University Hospital, SE-751 85 Uppsala, SwedenDepartment of Medical Sciences, Uppsala University, Uppsala University Hospital, SE-751 85 Uppsala, SwedenThe aim of the present study was to study the associations between urine albumin excretion, and a large number of urinary chemokines, cytokines, and growth factors in a normal population. We selected 90 urine samples from individuals without CVD, diabetes, stroke or kidney disease belonging to the Prospective Investigation of the Vasculature in Uppsala Seniors Study (41 males and 49 females, all aged 75 years). Urinary cytokine levels were analyzed with two multiplex assays (proximity extension assays) and the cytokine levels were correlated with urine albumin. After adjustment for sex, body mass index (BMI), estimated glomerular filtration rate (eGFR), smoking and multiplicity testing, 11 biomarkers remained significantly associated with urine albumin: thrombospondin 2, interleukin 6, interleukin 8, hepatocyte growth factor, matrix metalloproteinase-12 (MMP-12), C-X-C motif chemokine 9, tumor necrosis factor receptor superfamily member 11B, osteoprotegerin, growth-regulated alpha protein, C-X-C motif chemokine 6, oncostatin-M (OSM) and fatty acid-binding protein, intestinal, despite large differences in molecular weights. In this study, we found associations between urinary albumin and both small and large urine proteins. Additional studies are warranted to identify cytokine patterns and potential progression markers in various renal diseases.https://www.mdpi.com/2218-273X/11/3/396glomerular injuryurinethrombospondin 2interleukin 6interleukin 8hepatocyte growth factor |
| spellingShingle | Bengt Fellström Johanna Helmersson-Karlqvist Lars Lind Inga Soveri Måns Thulin Johan Ärnlöv Kim Kultima Anders Larsson Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans Biomolecules glomerular injury urine thrombospondin 2 interleukin 6 interleukin 8 hepatocyte growth factor |
| title | Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans |
| title_full | Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans |
| title_fullStr | Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans |
| title_full_unstemmed | Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans |
| title_short | Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans |
| title_sort | albumin urinary excretion is associated with increased levels of urinary chemokines cytokines and growth factors levels in humans |
| topic | glomerular injury urine thrombospondin 2 interleukin 6 interleukin 8 hepatocyte growth factor |
| url | https://www.mdpi.com/2218-273X/11/3/396 |
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