Binge Eating Disorder: A 5-Year Retrospective Study on Experimental Drugs
Michelle N Levitan,1,2 Marcelo Papelbaum,2 Mauro G Carta,3 Jose C Appolinario,1 Antonio E Nardi1 1Psychiatry Institute/Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; 2Eating Disorders Department/Sheba Medical Center, Ramat Gan, Israel; 3Dipartimento di Scienze Mediche e Sanit&agra...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-01-01
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| Series: | Journal of Experimental Pharmacology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/binge-eating-disorder-a-5-year-retrospective-study-on-experimental-dru-peer-reviewed-fulltext-article-JEP |
| _version_ | 1819029267632095232 |
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| author | Levitan MN Papelbaum M Carta MG Appolinario JC Nardi AE |
| author_facet | Levitan MN Papelbaum M Carta MG Appolinario JC Nardi AE |
| author_sort | Levitan MN |
| collection | DOAJ |
| description | Michelle N Levitan,1,2 Marcelo Papelbaum,2 Mauro G Carta,3 Jose C Appolinario,1 Antonio E Nardi1 1Psychiatry Institute/Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; 2Eating Disorders Department/Sheba Medical Center, Ramat Gan, Israel; 3Dipartimento di Scienze Mediche e Sanità Pubblica, Università Degli Studi di Cagliari, Cagliari, ItalyCorrespondence: Michelle N Levitan Email milevitan@gmail.comAbstract: Binge eating disorder (BED) affects a significant rate of the general population causing a negative impact on their quality of life, weight, and self-esteem. Besides psychological treatments that compose the majority of the studies, pharmaceuticals have contributed to improve a host of clinical parameters, thus being an important component of the treatment. We opted to target the latest results by performing a review of the literature on the pharmacology for BED from the last 5 years. To achieve this goal, the terms: “binge eating disorder” and “treatment” were added to the PubMed database and the website clinicaltrials.gov. At least five drugs were either being tested or had already been recognized to improve BED symptoms – although only lisdexamfetamine is currently approved by the FDA to treat this condition. However, due to a better understanding of BED psychopathology in the last decade, it is notorious that improvement of eating-related symptoms is not the only desired target. Due to the significant comorbidity percentage (30%), weight loss is highly pursued, as well as the amelioration of clinical parameters which highlights the importance of having new agents combining both objectives.Keywords: binge eating disorder, treatment, pharmacological treatment |
| first_indexed | 2024-12-21T06:11:33Z |
| format | Article |
| id | doaj.art-8b98484051da464b93b8641fd82fe640 |
| institution | Directory Open Access Journal |
| issn | 1179-1454 |
| language | English |
| last_indexed | 2024-12-21T06:11:33Z |
| publishDate | 2021-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Experimental Pharmacology |
| spelling | doaj.art-8b98484051da464b93b8641fd82fe6402022-12-21T19:13:32ZengDove Medical PressJournal of Experimental Pharmacology1179-14542021-01-01Volume 13334761593Binge Eating Disorder: A 5-Year Retrospective Study on Experimental DrugsLevitan MNPapelbaum MCarta MGAppolinario JCNardi AEMichelle N Levitan,1,2 Marcelo Papelbaum,2 Mauro G Carta,3 Jose C Appolinario,1 Antonio E Nardi1 1Psychiatry Institute/Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; 2Eating Disorders Department/Sheba Medical Center, Ramat Gan, Israel; 3Dipartimento di Scienze Mediche e Sanità Pubblica, Università Degli Studi di Cagliari, Cagliari, ItalyCorrespondence: Michelle N Levitan Email milevitan@gmail.comAbstract: Binge eating disorder (BED) affects a significant rate of the general population causing a negative impact on their quality of life, weight, and self-esteem. Besides psychological treatments that compose the majority of the studies, pharmaceuticals have contributed to improve a host of clinical parameters, thus being an important component of the treatment. We opted to target the latest results by performing a review of the literature on the pharmacology for BED from the last 5 years. To achieve this goal, the terms: “binge eating disorder” and “treatment” were added to the PubMed database and the website clinicaltrials.gov. At least five drugs were either being tested or had already been recognized to improve BED symptoms – although only lisdexamfetamine is currently approved by the FDA to treat this condition. However, due to a better understanding of BED psychopathology in the last decade, it is notorious that improvement of eating-related symptoms is not the only desired target. Due to the significant comorbidity percentage (30%), weight loss is highly pursued, as well as the amelioration of clinical parameters which highlights the importance of having new agents combining both objectives.Keywords: binge eating disorder, treatment, pharmacological treatmenthttps://www.dovepress.com/binge-eating-disorder-a-5-year-retrospective-study-on-experimental-dru-peer-reviewed-fulltext-article-JEPbinge eating disordertreatmentpharmacological treatment. |
| spellingShingle | Levitan MN Papelbaum M Carta MG Appolinario JC Nardi AE Binge Eating Disorder: A 5-Year Retrospective Study on Experimental Drugs Journal of Experimental Pharmacology binge eating disorder treatment pharmacological treatment. |
| title | Binge Eating Disorder: A 5-Year Retrospective Study on Experimental Drugs |
| title_full | Binge Eating Disorder: A 5-Year Retrospective Study on Experimental Drugs |
| title_fullStr | Binge Eating Disorder: A 5-Year Retrospective Study on Experimental Drugs |
| title_full_unstemmed | Binge Eating Disorder: A 5-Year Retrospective Study on Experimental Drugs |
| title_short | Binge Eating Disorder: A 5-Year Retrospective Study on Experimental Drugs |
| title_sort | binge eating disorder a 5 year retrospective study on experimental drugs |
| topic | binge eating disorder treatment pharmacological treatment. |
| url | https://www.dovepress.com/binge-eating-disorder-a-5-year-retrospective-study-on-experimental-dru-peer-reviewed-fulltext-article-JEP |
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