Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome
Abstract Background Marfan syndrome (MFS) is an inherited connective tissue disorder characterized by ectopia lentis, aortic root dilation and dissection and specific skeletal features. Obstructive sleep apnea (OSA) in MFS has been described earlier but the prevalence and its relation with the cardi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-08-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.805 |
| _version_ | 1797988207314337792 |
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| author | Laura Muiño‐Mosquera Fré Bauters Karlien Dhondt Hans De Wilde Luc Jordaens Katya De Groote Daniel De Wolf Katrien Hertegonne Julie De Backer |
| author_facet | Laura Muiño‐Mosquera Fré Bauters Karlien Dhondt Hans De Wilde Luc Jordaens Katya De Groote Daniel De Wolf Katrien Hertegonne Julie De Backer |
| author_sort | Laura Muiño‐Mosquera |
| collection | DOAJ |
| description | Abstract Background Marfan syndrome (MFS) is an inherited connective tissue disorder characterized by ectopia lentis, aortic root dilation and dissection and specific skeletal features. Obstructive sleep apnea (OSA) in MFS has been described earlier but the prevalence and its relation with the cardiovascular risk is still controversial. This study aimed to further investigate these aspects. Methods In this prospective longitudinal study, we performed an attended polysomnography in 40 MFS patients (60% women, 37 ± 12.8 years) and evaluated several cardiovascular parameters through echocardiography, resting electrocardiogram, 24 hr‐Holter monitoring and serum NT‐ProBNP measurements. Results We found that OSA was present in 42.5% of the patients and that higher body mass index was the most important factor associated with the presence of OSA. We observed that overweight was present in 27.5% of the patients in the whole cohort and in 55.6% if >40 years. Furthermore, when evaluating the impact of OSA on the cardiovascular system, we observed that patients with OSA tended to have higher systolic blood pressure, larger distal aortic diameters and a higher prevalence of ventricular arrhythmia. These differences were, however, not significant after adjusting for confounders. Conclusions Our study shows a high prevalence of OSA and a high prevalence of overweight in MFS patients. We found some trends between OSA and cardiovascular features but we could not establish a solid association. Our study, however might be underpowered, and a multicenter collaborative study could be very useful to answer some important open questions. |
| first_indexed | 2024-04-11T08:00:26Z |
| format | Article |
| id | doaj.art-8b9a4db5e8da401e8b3b6338f23375d9 |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-04-11T08:00:26Z |
| publishDate | 2019-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-8b9a4db5e8da401e8b3b6338f23375d92022-12-22T04:35:45ZengWileyMolecular Genetics & Genomic Medicine2324-92692019-08-0178n/an/a10.1002/mgg3.805Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndromeLaura Muiño‐Mosquera0Fré Bauters1Karlien Dhondt2Hans De Wilde3Luc Jordaens4Katya De Groote5Daniel De Wolf6Katrien Hertegonne7Julie De Backer8Centre for Medical Genetics Ghent University Hospital Ghent BelgiumDepartment of Pneumology Ghent University Hospital Ghent BelgiumDepartment of Pneumology Ghent University Hospital Ghent BelgiumDepartment of Pediatrics, Division of Pediatric Cardiology Ghent University Hospital Ghent BelgiumDepartment of Cardiology Ghent University Hospital Ghent BelgiumDepartment of Pediatrics, Division of Pediatric Cardiology Ghent University Hospital Ghent BelgiumDepartment of Pediatrics, Division of Pediatric Cardiology Ghent University Hospital Ghent BelgiumDepartment of Pneumology Ghent University Hospital Ghent BelgiumCentre for Medical Genetics Ghent University Hospital Ghent BelgiumAbstract Background Marfan syndrome (MFS) is an inherited connective tissue disorder characterized by ectopia lentis, aortic root dilation and dissection and specific skeletal features. Obstructive sleep apnea (OSA) in MFS has been described earlier but the prevalence and its relation with the cardiovascular risk is still controversial. This study aimed to further investigate these aspects. Methods In this prospective longitudinal study, we performed an attended polysomnography in 40 MFS patients (60% women, 37 ± 12.8 years) and evaluated several cardiovascular parameters through echocardiography, resting electrocardiogram, 24 hr‐Holter monitoring and serum NT‐ProBNP measurements. Results We found that OSA was present in 42.5% of the patients and that higher body mass index was the most important factor associated with the presence of OSA. We observed that overweight was present in 27.5% of the patients in the whole cohort and in 55.6% if >40 years. Furthermore, when evaluating the impact of OSA on the cardiovascular system, we observed that patients with OSA tended to have higher systolic blood pressure, larger distal aortic diameters and a higher prevalence of ventricular arrhythmia. These differences were, however, not significant after adjusting for confounders. Conclusions Our study shows a high prevalence of OSA and a high prevalence of overweight in MFS patients. We found some trends between OSA and cardiovascular features but we could not establish a solid association. Our study, however might be underpowered, and a multicenter collaborative study could be very useful to answer some important open questions.https://doi.org/10.1002/mgg3.805aortic aneurysmaortic dissectionarrhythmiacardiovascular riskMarfan syndromesleep apnea |
| spellingShingle | Laura Muiño‐Mosquera Fré Bauters Karlien Dhondt Hans De Wilde Luc Jordaens Katya De Groote Daniel De Wolf Katrien Hertegonne Julie De Backer Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome Molecular Genetics & Genomic Medicine aortic aneurysm aortic dissection arrhythmia cardiovascular risk Marfan syndrome sleep apnea |
| title | Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome |
| title_full | Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome |
| title_fullStr | Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome |
| title_full_unstemmed | Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome |
| title_short | Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome |
| title_sort | sleep apnea and the impact on cardiovascular risk in patients with marfan syndrome |
| topic | aortic aneurysm aortic dissection arrhythmia cardiovascular risk Marfan syndrome sleep apnea |
| url | https://doi.org/10.1002/mgg3.805 |
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