Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics
Wnt signaling is one of the important pathways to play a major role in various biological processes, such as embryonic stem-cell development, tissue regeneration, cell differentiation, and immune cell regulation. Recent studies suggest that Wnt signaling performs an essential function in immune cell...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/11/1380 |
| _version_ | 1797716799365578752 |
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| author | Muhammad Haseeb Rameez Hassan Pirzada Qurat Ul Ain Sangdun Choi |
| author_facet | Muhammad Haseeb Rameez Hassan Pirzada Qurat Ul Ain Sangdun Choi |
| author_sort | Muhammad Haseeb |
| collection | DOAJ |
| description | Wnt signaling is one of the important pathways to play a major role in various biological processes, such as embryonic stem-cell development, tissue regeneration, cell differentiation, and immune cell regulation. Recent studies suggest that Wnt signaling performs an essential function in immune cell modulation and counteracts various disorders. Nonetheless, the emerging role and mechanism of action of this signaling cascade in immune cell regulation, as well as its involvement in various cancers, remain debatable. The Wnt signaling in immune cells is very diverse, e.g., the tolerogenic role of dendritic cells, the development of natural killer cells, thymopoiesis of T cells, B-cell-driven initiation of T-cells, and macrophage actions in tissue repair, regeneration, and fibrosis. The purpose of this review is to highlight the current therapeutic targets in (and the prospects of) Wnt signaling, as well as the potential suitability of available modulators for the development of cancer immunotherapies. Although there are several Wnt inhibitors relevant to cancer, it would be worthwhile to extend this approach to immune cells. |
| first_indexed | 2024-03-12T08:27:53Z |
| format | Article |
| id | doaj.art-8b9bf04254b24f56869b4492f9480c34 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:27:53Z |
| publishDate | 2019-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8b9bf04254b24f56869b4492f9480c342023-09-02T18:01:08ZengMDPI AGCells2073-44092019-11-01811138010.3390/cells8111380cells8111380Wnt Signaling in the Regulation of Immune Cell and Cancer TherapeuticsMuhammad Haseeb0Rameez Hassan Pirzada1Qurat Ul Ain2Sangdun Choi3Department of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaDepartment of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaDepartment of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaDepartment of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaWnt signaling is one of the important pathways to play a major role in various biological processes, such as embryonic stem-cell development, tissue regeneration, cell differentiation, and immune cell regulation. Recent studies suggest that Wnt signaling performs an essential function in immune cell modulation and counteracts various disorders. Nonetheless, the emerging role and mechanism of action of this signaling cascade in immune cell regulation, as well as its involvement in various cancers, remain debatable. The Wnt signaling in immune cells is very diverse, e.g., the tolerogenic role of dendritic cells, the development of natural killer cells, thymopoiesis of T cells, B-cell-driven initiation of T-cells, and macrophage actions in tissue repair, regeneration, and fibrosis. The purpose of this review is to highlight the current therapeutic targets in (and the prospects of) Wnt signaling, as well as the potential suitability of available modulators for the development of cancer immunotherapies. Although there are several Wnt inhibitors relevant to cancer, it would be worthwhile to extend this approach to immune cells.https://www.mdpi.com/2073-4409/8/11/1380wnt signalingimmune cell regulationcancertherapeutic targetinhibitor |
| spellingShingle | Muhammad Haseeb Rameez Hassan Pirzada Qurat Ul Ain Sangdun Choi Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics Cells wnt signaling immune cell regulation cancer therapeutic target inhibitor |
| title | Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics |
| title_full | Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics |
| title_fullStr | Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics |
| title_full_unstemmed | Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics |
| title_short | Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics |
| title_sort | wnt signaling in the regulation of immune cell and cancer therapeutics |
| topic | wnt signaling immune cell regulation cancer therapeutic target inhibitor |
| url | https://www.mdpi.com/2073-4409/8/11/1380 |
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