Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite
Summary: Thirst and salt appetite are temporarily suppressed after water and salt ingestion, respectively, before absorption; however, the underlying neural mechanisms remain unclear. The parabrachial nucleus (PBN) is the relay center of ingestion signals from the digestive organs. We herein identif...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723016315 |
| _version_ | 1797372052716388352 |
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| author | Takashi Matsuda Kenta Kobayashi Kazuto Kobayashi Masaharu Noda |
| author_facet | Takashi Matsuda Kenta Kobayashi Kazuto Kobayashi Masaharu Noda |
| author_sort | Takashi Matsuda |
| collection | DOAJ |
| description | Summary: Thirst and salt appetite are temporarily suppressed after water and salt ingestion, respectively, before absorption; however, the underlying neural mechanisms remain unclear. The parabrachial nucleus (PBN) is the relay center of ingestion signals from the digestive organs. We herein identify two distinct neuronal populations expressing cholecystokinin (Cck) mRNA in the lateral PBN that are activated in response to water and salt intake, respectively. The two Cck neurons in the dorsal-lateral compartment of the PBN project to the median preoptic nucleus and ventral part of the bed nucleus of the stria terminalis, respectively. The optogenetic stimulation of respective Cck neurons suppresses thirst or salt appetite under water- or salt-depleted conditions. The combination of optogenetics and in vivo Ca2+ imaging during ingestion reveals that both Cck neurons control GABAergic neurons in their target nuclei. These findings provide the feedback mechanisms for the suppression of thirst and salt appetite after ingestion. |
| first_indexed | 2024-03-08T18:29:51Z |
| format | Article |
| id | doaj.art-8ba0e257508448fb8e66cb5f08973f1f |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-08T18:29:51Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-8ba0e257508448fb8e66cb5f08973f1f2023-12-30T04:44:12ZengElsevierCell Reports2211-12472024-01-01431113619Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetiteTakashi Matsuda0Kenta Kobayashi1Kazuto Kobayashi2Masaharu Noda3Homeostatic Mechanism Research Unit, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8503, JapanSection of Viral Vector Development, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, JapanDepartment of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima, Fukushima 960-1295, JapanHomeostatic Mechanism Research Unit, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8503, Japan; Corresponding authorSummary: Thirst and salt appetite are temporarily suppressed after water and salt ingestion, respectively, before absorption; however, the underlying neural mechanisms remain unclear. The parabrachial nucleus (PBN) is the relay center of ingestion signals from the digestive organs. We herein identify two distinct neuronal populations expressing cholecystokinin (Cck) mRNA in the lateral PBN that are activated in response to water and salt intake, respectively. The two Cck neurons in the dorsal-lateral compartment of the PBN project to the median preoptic nucleus and ventral part of the bed nucleus of the stria terminalis, respectively. The optogenetic stimulation of respective Cck neurons suppresses thirst or salt appetite under water- or salt-depleted conditions. The combination of optogenetics and in vivo Ca2+ imaging during ingestion reveals that both Cck neurons control GABAergic neurons in their target nuclei. These findings provide the feedback mechanisms for the suppression of thirst and salt appetite after ingestion.http://www.sciencedirect.com/science/article/pii/S2211124723016315CP: Neuroscience |
| spellingShingle | Takashi Matsuda Kenta Kobayashi Kazuto Kobayashi Masaharu Noda Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite Cell Reports CP: Neuroscience |
| title | Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite |
| title_full | Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite |
| title_fullStr | Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite |
| title_full_unstemmed | Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite |
| title_short | Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite |
| title_sort | two parabrachial cck neurons involved in the feedback control of thirst or salt appetite |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723016315 |
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