Estimation of salivary amylase and total proteins in leukemia patients and its correlation with clinical feature and radiographic finding
<b>Background:</b> Leukemia is a fatal disease. The oral manifestations of the leukemias occur early in the course of the disease and these oral features can at times act as a diagnostic indicator. Saliva has been used as a diagnostic aid in a number of systemic diseases. <b>Mate...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-01-01
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| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | http://www.ijdr.in/article.asp?issn=0970-9290;year=2010;volume=21;issue=4;spage=486;epage=490;aulast=Ashok |
| _version_ | 1818027293819273216 |
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| author | Ashok L Sujatha G Hema G |
| author_facet | Ashok L Sujatha G Hema G |
| author_sort | Ashok L |
| collection | DOAJ |
| description | <b>Background:</b> Leukemia is a fatal disease. The oral manifestations of the leukemias occur early in the course of the disease and these oral features can at times act as a diagnostic indicator. Saliva has been used as a diagnostic aid in a number of systemic diseases. <b>Materials and Methods:</b> In our study, samples of unstimulated saliva of 30 leukemia patients who were not on chemotherapy were collected and analyzed for salivary amylase and total protein. The oral manifestations and radiographic changes (OPG) were recorded. The correlation between the oral manifestations and the salivary components (salivary amylase and total protein) was assessed for prognostic significance. <b>Results:</b> In the present study when the mean values of salivary amylase (1280±754 U/ml) and total protein (647.2±320.7 mg%) were compared with that in control subjects. There was a statistically significant difference for amylase levels (<i>P</i><.05). On intraoral examination the study subjects showed pallor, gingivitis, gingival enlargement, petechiae, and ecchymosis. On the OPG, the radiographic features included generalized rarefaction of bone (20%), thinning of lamina dura (3.4%), generalized alveolar crest bone resorption (30%), thinning of walls of alveolar crypts (6.7%), besides others, e.g., periapical abscess (10%). <b>Conclusions:</b> The saliva of leukemic patients demonstrated obvious changes in composition. A rise in salivary amylase and total protein levels was evident, with the increase in amylase levels being statistically significant. |
| first_indexed | 2024-12-10T04:45:36Z |
| format | Article |
| id | doaj.art-8ba275e67875480194e44c4ccb2ad387 |
| institution | Directory Open Access Journal |
| issn | 0970-9290 1998-3603 |
| language | English |
| last_indexed | 2024-12-10T04:45:36Z |
| publishDate | 2010-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj.art-8ba275e67875480194e44c4ccb2ad3872022-12-22T02:01:46ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032010-01-01214486490Estimation of salivary amylase and total proteins in leukemia patients and its correlation with clinical feature and radiographic findingAshok LSujatha GHema G<b>Background:</b> Leukemia is a fatal disease. The oral manifestations of the leukemias occur early in the course of the disease and these oral features can at times act as a diagnostic indicator. Saliva has been used as a diagnostic aid in a number of systemic diseases. <b>Materials and Methods:</b> In our study, samples of unstimulated saliva of 30 leukemia patients who were not on chemotherapy were collected and analyzed for salivary amylase and total protein. The oral manifestations and radiographic changes (OPG) were recorded. The correlation between the oral manifestations and the salivary components (salivary amylase and total protein) was assessed for prognostic significance. <b>Results:</b> In the present study when the mean values of salivary amylase (1280±754 U/ml) and total protein (647.2±320.7 mg%) were compared with that in control subjects. There was a statistically significant difference for amylase levels (<i>P</i><.05). On intraoral examination the study subjects showed pallor, gingivitis, gingival enlargement, petechiae, and ecchymosis. On the OPG, the radiographic features included generalized rarefaction of bone (20%), thinning of lamina dura (3.4%), generalized alveolar crest bone resorption (30%), thinning of walls of alveolar crypts (6.7%), besides others, e.g., periapical abscess (10%). <b>Conclusions:</b> The saliva of leukemic patients demonstrated obvious changes in composition. A rise in salivary amylase and total protein levels was evident, with the increase in amylase levels being statistically significant.http://www.ijdr.in/article.asp?issn=0970-9290;year=2010;volume=21;issue=4;spage=486;epage=490;aulast=AshokLeukemiasalivary amylasesalivary total protein |
| spellingShingle | Ashok L Sujatha G Hema G Estimation of salivary amylase and total proteins in leukemia patients and its correlation with clinical feature and radiographic finding Indian Journal of Dental Research Leukemia salivary amylase salivary total protein |
| title | Estimation of salivary amylase and total proteins in leukemia patients and its correlation with clinical feature and radiographic finding |
| title_full | Estimation of salivary amylase and total proteins in leukemia patients and its correlation with clinical feature and radiographic finding |
| title_fullStr | Estimation of salivary amylase and total proteins in leukemia patients and its correlation with clinical feature and radiographic finding |
| title_full_unstemmed | Estimation of salivary amylase and total proteins in leukemia patients and its correlation with clinical feature and radiographic finding |
| title_short | Estimation of salivary amylase and total proteins in leukemia patients and its correlation with clinical feature and radiographic finding |
| title_sort | estimation of salivary amylase and total proteins in leukemia patients and its correlation with clinical feature and radiographic finding |
| topic | Leukemia salivary amylase salivary total protein |
| url | http://www.ijdr.in/article.asp?issn=0970-9290;year=2010;volume=21;issue=4;spage=486;epage=490;aulast=Ashok |
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