Frequency of deep-seated cerebral microbleeds in patients with lobar hemorrhages and histopathological evidence for cerebral amyloid angiopathy
BackgroundCerebral amyloid angiopathy (CAA) is a common disease and the most common cause of lobar hemorrhages in the elderly. Usually, deep-seated microhemorrhages preclude the diagnosis of CAA. In this study, we sought to estimate the frequency of deep-seated microbleeds on MRI in patients with lo...
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| Format: | Article |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1146737/full |
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| author | Monika Huhndorf Christoph Röcken Charlotte Flüh Caroline Weiler Gregor Kuhlenbäumer Nora Tegeler Hannes Schacht Alexander Neumann Nils G. Margraf Ulf Jensen-Kondering Ulf Jensen-Kondering |
| author_facet | Monika Huhndorf Christoph Röcken Charlotte Flüh Caroline Weiler Gregor Kuhlenbäumer Nora Tegeler Hannes Schacht Alexander Neumann Nils G. Margraf Ulf Jensen-Kondering Ulf Jensen-Kondering |
| author_sort | Monika Huhndorf |
| collection | DOAJ |
| description | BackgroundCerebral amyloid angiopathy (CAA) is a common disease and the most common cause of lobar hemorrhages in the elderly. Usually, deep-seated microhemorrhages preclude the diagnosis of CAA. In this study, we sought to estimate the frequency of deep-seated microbleeds on MRI in patients with lobar hemorrhages and histopathological evidence for cerebral amyloid angiopathy. In addition, we describe a cohort of patients with cortical and deep-seated microbleeds on MRI and a histopathological specimen available from lobar hematoma evacuation.MethodsRetrospective database search for histopathological specimens from lobar hematoma evacuation and review of imaging findings (CT and MRI) and patient charts was performed.ResultsBetween 1 January 2012 and 31 December 2020, 88 specimens from 88 patients were available. A total of 56 specimens were excluded (no brain tissue in the specimen n = 4, other diagnosis n = 8, no MRI n = 43, and no BOLD-based sequence n = 1). Of the remaining 32 patients, 25 patients (78%) did not harbor deep-seated lesions on MRI, of which 17 patients had histopathological features of CAA. A total of seven patients harbored deep-seated CMB. Of these seven patients, three (3/20, 15%) had histopathological features of CAA.ConclusionApproximately 15% of patients with histopathologically diagnosed CAA harbor deep-seated microbleeds. This finding may add to the discussion on how to identify patients with CAA and deep-seated CMB. |
| first_indexed | 2024-04-09T18:24:28Z |
| format | Article |
| id | doaj.art-8ba395befd384959a478beef0a450499 |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T18:24:28Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-8ba395befd384959a478beef0a4504992023-04-12T05:07:13ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-04-011410.3389/fneur.2023.11467371146737Frequency of deep-seated cerebral microbleeds in patients with lobar hemorrhages and histopathological evidence for cerebral amyloid angiopathyMonika Huhndorf0Christoph Röcken1Charlotte Flüh2Caroline Weiler3Gregor Kuhlenbäumer4Nora Tegeler5Hannes Schacht6Alexander Neumann7Nils G. Margraf8Ulf Jensen-Kondering9Ulf Jensen-Kondering10Department of Radiology and Neuroradiology, Universitätsklinikum Schleswig-Holstein (UKSH), Kiel, GermanyDepartment of Pathology, Universitätsklinikum Schleswig-Holstein (UKSH), Kiel, GermanyDepartment of Neurosurgery, Universitätsklinikum Schleswig-Holstein (UKSH), Kiel, GermanyDepartment of Neurology, Universitätsklinikum Schleswig-Holstein (UKSH), Kiel, GermanyDepartment of Neurology, Universitätsklinikum Schleswig-Holstein (UKSH), Kiel, GermanyDepartment of Neurosurgery, Universitätsklinikum Schleswig-Holstein (UKSH), Kiel, GermanyDepartment of Neuroradiology, Universitätsklinikum Schleswig-Holstein (UKSH), Lübeck, GermanyDepartment of Neuroradiology, Universitätsklinikum Schleswig-Holstein (UKSH), Lübeck, GermanyDepartment of Neurology, Universitätsklinikum Schleswig-Holstein (UKSH), Kiel, GermanyDepartment of Radiology and Neuroradiology, Universitätsklinikum Schleswig-Holstein (UKSH), Kiel, GermanyDepartment of Neuroradiology, Universitätsklinikum Schleswig-Holstein (UKSH), Lübeck, GermanyBackgroundCerebral amyloid angiopathy (CAA) is a common disease and the most common cause of lobar hemorrhages in the elderly. Usually, deep-seated microhemorrhages preclude the diagnosis of CAA. In this study, we sought to estimate the frequency of deep-seated microbleeds on MRI in patients with lobar hemorrhages and histopathological evidence for cerebral amyloid angiopathy. In addition, we describe a cohort of patients with cortical and deep-seated microbleeds on MRI and a histopathological specimen available from lobar hematoma evacuation.MethodsRetrospective database search for histopathological specimens from lobar hematoma evacuation and review of imaging findings (CT and MRI) and patient charts was performed.ResultsBetween 1 January 2012 and 31 December 2020, 88 specimens from 88 patients were available. A total of 56 specimens were excluded (no brain tissue in the specimen n = 4, other diagnosis n = 8, no MRI n = 43, and no BOLD-based sequence n = 1). Of the remaining 32 patients, 25 patients (78%) did not harbor deep-seated lesions on MRI, of which 17 patients had histopathological features of CAA. A total of seven patients harbored deep-seated CMB. Of these seven patients, three (3/20, 15%) had histopathological features of CAA.ConclusionApproximately 15% of patients with histopathologically diagnosed CAA harbor deep-seated microbleeds. This finding may add to the discussion on how to identify patients with CAA and deep-seated CMB.https://www.frontiersin.org/articles/10.3389/fneur.2023.1146737/fullCAABoston criteriaMRIhistopathologyCT |
| spellingShingle | Monika Huhndorf Christoph Röcken Charlotte Flüh Caroline Weiler Gregor Kuhlenbäumer Nora Tegeler Hannes Schacht Alexander Neumann Nils G. Margraf Ulf Jensen-Kondering Ulf Jensen-Kondering Frequency of deep-seated cerebral microbleeds in patients with lobar hemorrhages and histopathological evidence for cerebral amyloid angiopathy Frontiers in Neurology CAA Boston criteria MRI histopathology CT |
| title | Frequency of deep-seated cerebral microbleeds in patients with lobar hemorrhages and histopathological evidence for cerebral amyloid angiopathy |
| title_full | Frequency of deep-seated cerebral microbleeds in patients with lobar hemorrhages and histopathological evidence for cerebral amyloid angiopathy |
| title_fullStr | Frequency of deep-seated cerebral microbleeds in patients with lobar hemorrhages and histopathological evidence for cerebral amyloid angiopathy |
| title_full_unstemmed | Frequency of deep-seated cerebral microbleeds in patients with lobar hemorrhages and histopathological evidence for cerebral amyloid angiopathy |
| title_short | Frequency of deep-seated cerebral microbleeds in patients with lobar hemorrhages and histopathological evidence for cerebral amyloid angiopathy |
| title_sort | frequency of deep seated cerebral microbleeds in patients with lobar hemorrhages and histopathological evidence for cerebral amyloid angiopathy |
| topic | CAA Boston criteria MRI histopathology CT |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1146737/full |
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