GLUTATHIONE DYNAMICS IN THE SECOND GENERATION YOUNG RATS BLOOD AS A CONSEQUENCE OF FEMALE EXPOSURE TO Cr(VI) INTOXICATION DURING GESTATION
Chromium compounds are found in the environment, due to erosion of chromium containing rocks and can be distributed by volcanic eruptions in food, water. Metals being non-biodegradable persist in the environment for a long period and cause serious ecotoxicological problems. Chromium, which exists in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Agroprint Timisoara
2023-10-01
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| Series: | Scientific Papers Animal Science and Biotechnologies |
| Subjects: | |
| Online Access: | https://spasb.ro/index.php/public_html/article/view/1292 |
| Summary: | Chromium compounds are found in the environment, due to erosion of chromium
containing rocks and can be distributed by volcanic eruptions in food, water.
Metals being non-biodegradable persist in the environment for a long period and
cause serious ecotoxicological problems. Chromium, which exists in nature mostly
in the trivalent form (Cr+3), is essential for activating certain enzymes and for
stabilizing proteins and nucleic acids. We have studied the influence of the
glutathione dynamics in the second generation rats blood, as a consequence of
females chromium (VI) intoxication during the gestation. This study was carried
out on 7 Wistar adult female rats, control group (C), 21 adult Wistar female rats,
devided in three experimental groups (E) and theire young rats. The rats were feet,
durind the gestation, with 25ppm (LOAEL), 50ppm and 75ppm potassium
dichromate, ad libitum, in drinking water. The control batch received tap water.
Reduced glutathione (GSH) was measured quantitatively after the wean using a
Perkin-Elmer spectrophotometer, through Beutler et al. method, at 412nm. The
study reports also the depletion of young rats blood GSH. |
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| ISSN: | 1841-9364 2344-4576 |