WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm
We report a 50-year-old woman with no relevant clinical history who presented with headache and loss of memory. Magnetic resonance imaging showed a left parieto-temporal mass with annular enhancement after contrast media administration, rendering a radiological diagnosis of high-grade astrocytic neo...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Pathologists & the Korean Society for Cytopathology
2015-07-01
|
| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-49-4-325.pdf |
| _version_ | 1831789065258663936 |
|---|---|
| author | Paola A. Escalante Abril Miguel Fdo. Salazar Nubia L. López García Mónica N. Madrazo Moya Yadir U. Zamora Guerra Yadira Gandhi Mata Mendoza Erick Gómez Apo Laura G. Chávez Macías |
| author_facet | Paola A. Escalante Abril Miguel Fdo. Salazar Nubia L. López García Mónica N. Madrazo Moya Yadir U. Zamora Guerra Yadira Gandhi Mata Mendoza Erick Gómez Apo Laura G. Chávez Macías |
| author_sort | Paola A. Escalante Abril |
| collection | DOAJ |
| description | We report a 50-year-old woman with no relevant clinical history who presented with headache and loss of memory. Magnetic resonance imaging showed a left parieto-temporal mass with annular enhancement after contrast media administration, rendering a radiological diagnosis of high-grade astrocytic neoplasm. Tumour sampling was performed but the patient ultimately died as a result of disease. Microscopically, the lesion had areas of glioblastoma mixed with a benign mesenchymal constituent; the former showed hypercellularity, endothelial proliferation, high mitotic activity and necrosis, while the latter showed fascicles of long spindle cells surrounded by collagen and reticulin fibers. With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal. As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component. |
| first_indexed | 2024-12-22T14:01:17Z |
| format | Article |
| id | doaj.art-8ba90ffcd6194474bf2f85e2131918ba |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-22T14:01:17Z |
| publishDate | 2015-07-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-8ba90ffcd6194474bf2f85e2131918ba2022-12-21T18:23:24ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452015-07-0149432533010.4132/jptm.2015.05.2016533WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted NeoplasmPaola A. Escalante AbrilMiguel Fdo. SalazarNubia L. López GarcíaMónica N. Madrazo MoyaYadir U. Zamora GuerraYadira Gandhi Mata MendozaErick Gómez ApoLaura G. Chávez MacíasWe report a 50-year-old woman with no relevant clinical history who presented with headache and loss of memory. Magnetic resonance imaging showed a left parieto-temporal mass with annular enhancement after contrast media administration, rendering a radiological diagnosis of high-grade astrocytic neoplasm. Tumour sampling was performed but the patient ultimately died as a result of disease. Microscopically, the lesion had areas of glioblastoma mixed with a benign mesenchymal constituent; the former showed hypercellularity, endothelial proliferation, high mitotic activity and necrosis, while the latter showed fascicles of long spindle cells surrounded by collagen and reticulin fibers. With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal. As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component.http://www.jpatholtm.org/upload/pdf/jptm-49-4-325.pdfGliofibromaBimorphic neoplasmDesmoplastic gliomaAdult populationTumour suppressor protein 53 |
| spellingShingle | Paola A. Escalante Abril Miguel Fdo. Salazar Nubia L. López García Mónica N. Madrazo Moya Yadir U. Zamora Guerra Yadira Gandhi Mata Mendoza Erick Gómez Apo Laura G. Chávez Macías WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm Journal of Pathology and Translational Medicine Gliofibroma Bimorphic neoplasm Desmoplastic glioma Adult population Tumour suppressor protein 53 |
| title | WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm |
| title_full | WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm |
| title_fullStr | WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm |
| title_full_unstemmed | WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm |
| title_short | WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm |
| title_sort | who grade iv gliofibroma a grading label denoting malignancy for an otherwise commonly misinterpreted neoplasm |
| topic | Gliofibroma Bimorphic neoplasm Desmoplastic glioma Adult population Tumour suppressor protein 53 |
| url | http://www.jpatholtm.org/upload/pdf/jptm-49-4-325.pdf |
| work_keys_str_mv | AT paolaaescalanteabril whogradeivgliofibromaagradinglabeldenotingmalignancyforanotherwisecommonlymisinterpretedneoplasm AT miguelfdosalazar whogradeivgliofibromaagradinglabeldenotingmalignancyforanotherwisecommonlymisinterpretedneoplasm AT nubiallopezgarcia whogradeivgliofibromaagradinglabeldenotingmalignancyforanotherwisecommonlymisinterpretedneoplasm AT monicanmadrazomoya whogradeivgliofibromaagradinglabeldenotingmalignancyforanotherwisecommonlymisinterpretedneoplasm AT yadiruzamoraguerra whogradeivgliofibromaagradinglabeldenotingmalignancyforanotherwisecommonlymisinterpretedneoplasm AT yadiragandhimatamendoza whogradeivgliofibromaagradinglabeldenotingmalignancyforanotherwisecommonlymisinterpretedneoplasm AT erickgomezapo whogradeivgliofibromaagradinglabeldenotingmalignancyforanotherwisecommonlymisinterpretedneoplasm AT lauragchavezmacias whogradeivgliofibromaagradinglabeldenotingmalignancyforanotherwisecommonlymisinterpretedneoplasm |