Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke
Background: Somatosensory deficits are frequently seen in acute stroke patients and may recover over time and affect functional outcome. However, the underlying mechanism of function recovery remains poorly understood. In the present study, progressive function alteration of the secondary somatosens...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Current Research in Neurobiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665945X23000256 |
| _version_ | 1797794010427817984 |
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| author | Chun-Xia Li Frank Tong Doty Kempf Leonard Howell Xiaodong Zhang |
| author_facet | Chun-Xia Li Frank Tong Doty Kempf Leonard Howell Xiaodong Zhang |
| author_sort | Chun-Xia Li |
| collection | DOAJ |
| description | Background: Somatosensory deficits are frequently seen in acute stroke patients and may recover over time and affect functional outcome. However, the underlying mechanism of function recovery remains poorly understood. In the present study, progressive function alteration of the secondary somatosensory cortex (S2) and its relationship with regional perfusion and neurological outcome were examined using a monkey model of stroke. Methods and materials: Rhesus monkeys (n = 4) were induced with permanent middle cerebral artery occlusion (pMCAo). Resting-state functional MRI, dynamic susceptibility contrast perfusion MRI, diffusion-weighted, T1 and T2 weighted images were collected before surgery and at 4–6, 48, and 96 h post stroke on a 3T scanner. Progressive changes of relative functional connectivity (FC), cerebral blood flow (CBF), and CBF/Tmax (Time to Maximum) of affected S2 regions were evaluated. Neurological deficits were assessed using the Spetzler approach. Results: Ischemic lesion was evidently seen in the MCA territory including S2 in each monkey. Relative FC of injured S2 regions decreased substantially following stroke. Spetzler scores dropped substantially at 24 h post stroke but slightly recovered from Day 2 to Day 4. Relative FC progressively increased from 6 to 48 and 96 h post stroke and correlated significantly with relative CBFand CBF/Tmax changes. Conclusion: The present study revealed the progressive alteration of function connectivity in S2 during acute stroke. The preliminary results suggested the function recovery might start couple days post occlusion and collateral circulation might play a key role in the recovery of somatosensory function after stroke insult. The relative function connectivity in S2 may provide additional information for prediction of functional outcome in stroke patients. |
| first_indexed | 2024-03-13T02:55:39Z |
| format | Article |
| id | doaj.art-8baceb1aa6c943f9a2342c7bffd0cffc |
| institution | Directory Open Access Journal |
| issn | 2665-945X |
| language | English |
| last_indexed | 2024-03-13T02:55:39Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Neurobiology |
| spelling | doaj.art-8baceb1aa6c943f9a2342c7bffd0cffc2023-06-28T04:30:26ZengElsevierCurrent Research in Neurobiology2665-945X2023-01-015100097Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute strokeChun-Xia Li0Frank Tong1Doty Kempf2Leonard Howell3Xiaodong Zhang4Emory National Primate Research Center, Emory University, Atlanta, 30329, GeorgiaDepartment of Radiology, Emory University School of Medicine, Atlanta, 30322, GeorgiaEmory National Primate Research Center, Emory University, Atlanta, 30329, GeorgiaEmory National Primate Research Center, Emory University, Atlanta, 30329, GeorgiaEmory National Primate Research Center, Emory University, Atlanta, 30329, Georgia; Corresponding author. EPC Imaging Center, Emory University, 954 Gatewood Rd NE, Atlanta, GA 30329, USA.Background: Somatosensory deficits are frequently seen in acute stroke patients and may recover over time and affect functional outcome. However, the underlying mechanism of function recovery remains poorly understood. In the present study, progressive function alteration of the secondary somatosensory cortex (S2) and its relationship with regional perfusion and neurological outcome were examined using a monkey model of stroke. Methods and materials: Rhesus monkeys (n = 4) were induced with permanent middle cerebral artery occlusion (pMCAo). Resting-state functional MRI, dynamic susceptibility contrast perfusion MRI, diffusion-weighted, T1 and T2 weighted images were collected before surgery and at 4–6, 48, and 96 h post stroke on a 3T scanner. Progressive changes of relative functional connectivity (FC), cerebral blood flow (CBF), and CBF/Tmax (Time to Maximum) of affected S2 regions were evaluated. Neurological deficits were assessed using the Spetzler approach. Results: Ischemic lesion was evidently seen in the MCA territory including S2 in each monkey. Relative FC of injured S2 regions decreased substantially following stroke. Spetzler scores dropped substantially at 24 h post stroke but slightly recovered from Day 2 to Day 4. Relative FC progressively increased from 6 to 48 and 96 h post stroke and correlated significantly with relative CBFand CBF/Tmax changes. Conclusion: The present study revealed the progressive alteration of function connectivity in S2 during acute stroke. The preliminary results suggested the function recovery might start couple days post occlusion and collateral circulation might play a key role in the recovery of somatosensory function after stroke insult. The relative function connectivity in S2 may provide additional information for prediction of functional outcome in stroke patients.http://www.sciencedirect.com/science/article/pii/S2665945X23000256Somatosensory deficitrsfMRINon-human primatePerfusionMCAO |
| spellingShingle | Chun-Xia Li Frank Tong Doty Kempf Leonard Howell Xiaodong Zhang Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke Current Research in Neurobiology Somatosensory deficit rsfMRI Non-human primate Perfusion MCAO |
| title | Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke |
| title_full | Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke |
| title_fullStr | Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke |
| title_full_unstemmed | Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke |
| title_short | Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke |
| title_sort | longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex s2 of the monkey brain during acute stroke |
| topic | Somatosensory deficit rsfMRI Non-human primate Perfusion MCAO |
| url | http://www.sciencedirect.com/science/article/pii/S2665945X23000256 |
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