The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates
Background: Jaundice is one of the most common conditions confronting neonatologists daily. Phototherapy is generally regarded as a safe method for treating hyperbilirubinemia, but it may also lead to undesired effects, one of these effects that it can affect the function of the immune system of the...
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| Format: | Article |
| Language: | English |
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Al-Azhar University, Faculty of Medicine (Damietta)
2020-01-01
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| Series: | International Journal of Medical Arts |
| Subjects: | |
| Online Access: | https://ijma.journals.ekb.eg/article_55919_e2a9773c283cc915f103b895f0e0ce9b.pdf |
| _version_ | 1818427535123283968 |
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| author | Mohamed Neam Mohamed Zannoun |
| author_facet | Mohamed Neam Mohamed Zannoun |
| author_sort | Mohamed Neam |
| collection | DOAJ |
| description | Background: Jaundice is one of the most common conditions confronting neonatologists daily. Phototherapy is generally regarded as a safe method for treating hyperbilirubinemia, but it may also lead to undesired effects, one of these effects that it can affect the function of the immune system of the newborn. Aim of the work: The aim of the work was to study the effect of phototherapy on the serum level of tumor necrosis factor- alpha [TNF-α] in neonates. Patients and methods: A total of 35 cases of term neonates with Neonatal Jaundice and indirect hyperbilirubinemia high to the level that need phototherapy for 72hrs or more according to the guidelines of the American Academy of Pediatrics were included in this study, and 15 healthy matched newborns were selected as controls. TNF-α was measured before exposure and after 72 hours phototherapy and from control group at the time of examination. Serum levels of TNF alpha were measured using enzyme linked immunosorbent assay kits. Results: The results showed that there was no statistically significant in patient group before phototherapy in comparison to control group as regards TNF-α, patient demographics or laboratory data. On the other side, serum TNF-α levels significantly increased after exposure to phototherapy for 72 hours when compared to values before phototherapy (151.49±61.97 vs 61.36±31.96 respectively), indicating the influence of phototherapy on serum level of TNF-α. Conclusion: The results demonstrated increased serum TNF-α level after 72 hours may affect the immune system in neonates. |
| first_indexed | 2024-12-14T14:47:16Z |
| format | Article |
| id | doaj.art-8bad20a3a7a244bdb9c76040bab197e0 |
| institution | Directory Open Access Journal |
| issn | 2636-4174 2682-3780 |
| language | English |
| last_indexed | 2024-12-14T14:47:16Z |
| publishDate | 2020-01-01 |
| publisher | Al-Azhar University, Faculty of Medicine (Damietta) |
| record_format | Article |
| series | International Journal of Medical Arts |
| spelling | doaj.art-8bad20a3a7a244bdb9c76040bab197e02022-12-21T22:57:15ZengAl-Azhar University, Faculty of Medicine (Damietta)International Journal of Medical Arts2636-41742682-37802020-01-012115716110.21608/ijma.2019.12655.100455919The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in NeonatesMohamed Neam0Mohamed Zannoun1Department of Pediatrics, Damanhour General Hospital, Ministry of Health, EgyptDepartment of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, EgyptBackground: Jaundice is one of the most common conditions confronting neonatologists daily. Phototherapy is generally regarded as a safe method for treating hyperbilirubinemia, but it may also lead to undesired effects, one of these effects that it can affect the function of the immune system of the newborn. Aim of the work: The aim of the work was to study the effect of phototherapy on the serum level of tumor necrosis factor- alpha [TNF-α] in neonates. Patients and methods: A total of 35 cases of term neonates with Neonatal Jaundice and indirect hyperbilirubinemia high to the level that need phototherapy for 72hrs or more according to the guidelines of the American Academy of Pediatrics were included in this study, and 15 healthy matched newborns were selected as controls. TNF-α was measured before exposure and after 72 hours phototherapy and from control group at the time of examination. Serum levels of TNF alpha were measured using enzyme linked immunosorbent assay kits. Results: The results showed that there was no statistically significant in patient group before phototherapy in comparison to control group as regards TNF-α, patient demographics or laboratory data. On the other side, serum TNF-α levels significantly increased after exposure to phototherapy for 72 hours when compared to values before phototherapy (151.49±61.97 vs 61.36±31.96 respectively), indicating the influence of phototherapy on serum level of TNF-α. Conclusion: The results demonstrated increased serum TNF-α level after 72 hours may affect the immune system in neonates.https://ijma.journals.ekb.eg/article_55919_e2a9773c283cc915f103b895f0e0ce9b.pdfphototherapyjaundiceimmune systemcytokinesneonate |
| spellingShingle | Mohamed Neam Mohamed Zannoun The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates International Journal of Medical Arts phototherapy jaundice immune system cytokines neonate |
| title | The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates |
| title_full | The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates |
| title_fullStr | The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates |
| title_full_unstemmed | The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates |
| title_short | The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates |
| title_sort | effect of phototherapy on serum level of tumor necrosis factor alpha in neonates |
| topic | phototherapy jaundice immune system cytokines neonate |
| url | https://ijma.journals.ekb.eg/article_55919_e2a9773c283cc915f103b895f0e0ce9b.pdf |
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