Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer
Abstract Colorectal cancer is considered one of the major malignancies that threaten the lives and health of people around the world. Patients with CRC are prone to post-operative local recurrence or metastasis, and some patients are advanced at the time of diagnosis and have no chance for complete...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01586-4 |
| _version_ | 1798037722190839808 |
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| author | Yu Guo Min Wang Yongbo Zou Longhai Jin Zeyun Zhao Qi Liu Shuang Wang Jiannan Li |
| author_facet | Yu Guo Min Wang Yongbo Zou Longhai Jin Zeyun Zhao Qi Liu Shuang Wang Jiannan Li |
| author_sort | Yu Guo |
| collection | DOAJ |
| description | Abstract Colorectal cancer is considered one of the major malignancies that threaten the lives and health of people around the world. Patients with CRC are prone to post-operative local recurrence or metastasis, and some patients are advanced at the time of diagnosis and have no chance for complete surgical resection. These factors make chemotherapy an indispensable and important tool in treating CRC. However, the complex composition of the tumor microenvironment and the interaction of cellular and interstitial components constitute a tumor tissue with high cell density, dense extracellular matrix, and high osmotic pressure, inevitably preventing chemotherapeutic drugs from entering and acting on tumor cells. As a result, a novel drug carrier system with targeted nanoparticles has been applied to tumor therapy. It can change the physicochemical properties of drugs, facilitate the crossing of drug molecules through physiological and pathological tissue barriers, and increase the local concentration of nanomedicines at lesion sites. In addition to improving drug efficacy, targeted nanoparticles also reduce side effects, enabling safer and more effective disease diagnosis and treatment and improving bioavailability. In this review, we discuss the mechanisms by which infiltrating cells and other stromal components of the tumor microenvironment comprise barriers to chemotherapy in colorectal cancer. The research and application of targeted nanoparticles in CRC treatment are also classified. |
| first_indexed | 2024-04-11T21:30:25Z |
| format | Article |
| id | doaj.art-8badd32aaa4545549862e7b1c198c274 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T21:30:25Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-8badd32aaa4545549862e7b1c198c2742022-12-22T04:02:00ZengBMCJournal of Nanobiotechnology1477-31552022-08-0120112410.1186/s12951-022-01586-4Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancerYu Guo0Min Wang1Yongbo Zou2Longhai Jin3Zeyun Zhao4Qi Liu5Shuang Wang6Jiannan Li7Department of the General Surgery, Jilin University Second HospitalDepartment of the General Surgery, Jilin University Second HospitalDepartment of the General Surgery, Jilin University Second HospitalDepartment of Radiology, Jilin University Second HospitalDepartment of the General Surgery, Jilin University Second HospitalDepartment of the General Surgery, Jilin University Second HospitalDepartment of the Dermatology, Jilin University Second HospitalDepartment of the General Surgery, Jilin University Second HospitalAbstract Colorectal cancer is considered one of the major malignancies that threaten the lives and health of people around the world. Patients with CRC are prone to post-operative local recurrence or metastasis, and some patients are advanced at the time of diagnosis and have no chance for complete surgical resection. These factors make chemotherapy an indispensable and important tool in treating CRC. However, the complex composition of the tumor microenvironment and the interaction of cellular and interstitial components constitute a tumor tissue with high cell density, dense extracellular matrix, and high osmotic pressure, inevitably preventing chemotherapeutic drugs from entering and acting on tumor cells. As a result, a novel drug carrier system with targeted nanoparticles has been applied to tumor therapy. It can change the physicochemical properties of drugs, facilitate the crossing of drug molecules through physiological and pathological tissue barriers, and increase the local concentration of nanomedicines at lesion sites. In addition to improving drug efficacy, targeted nanoparticles also reduce side effects, enabling safer and more effective disease diagnosis and treatment and improving bioavailability. In this review, we discuss the mechanisms by which infiltrating cells and other stromal components of the tumor microenvironment comprise barriers to chemotherapy in colorectal cancer. The research and application of targeted nanoparticles in CRC treatment are also classified.https://doi.org/10.1186/s12951-022-01586-4Colorectal cancerTargeted nanoparticlesChemotherapeutic resistance |
| spellingShingle | Yu Guo Min Wang Yongbo Zou Longhai Jin Zeyun Zhao Qi Liu Shuang Wang Jiannan Li Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer Journal of Nanobiotechnology Colorectal cancer Targeted nanoparticles Chemotherapeutic resistance |
| title | Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer |
| title_full | Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer |
| title_fullStr | Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer |
| title_full_unstemmed | Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer |
| title_short | Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer |
| title_sort | mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer |
| topic | Colorectal cancer Targeted nanoparticles Chemotherapeutic resistance |
| url | https://doi.org/10.1186/s12951-022-01586-4 |
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