MXene: An efficient hemoperfusion sorbent for the removal of uremic toxins
MXene, a family of two-dimensional (2D) transition metal carbides and nitrides have attracted extensive interests for many biochemical applications, including tumour elimination, biosensors, and magnetic resonance imaging (MRI). In this article, we firstly discovered that Ti3C2Tx MXene exhibited a h...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Journal of Materiomics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352847823001223 |
| _version_ | 1797582948694753280 |
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| author | Tianyi Wang Wei Gu Lu Yu Xin Guo Jian Yang Xiaoyu Sun Jun Guan Lin Zhou Chengyin Wang Hang Yao Xiuyun Zhang Guoxiu Wang |
| author_facet | Tianyi Wang Wei Gu Lu Yu Xin Guo Jian Yang Xiaoyu Sun Jun Guan Lin Zhou Chengyin Wang Hang Yao Xiuyun Zhang Guoxiu Wang |
| author_sort | Tianyi Wang |
| collection | DOAJ |
| description | MXene, a family of two-dimensional (2D) transition metal carbides and nitrides have attracted extensive interests for many biochemical applications, including tumour elimination, biosensors, and magnetic resonance imaging (MRI). In this article, we firstly discovered that Ti3C2Tx MXene exhibited a highly efficient adsorption capability as hemoperfusion absorbent towards middle-molecular mass and protein bound uremic toxins in the end stage of renal disease (ESRD) treatment. Molecular scale investigations reveal that the high efficiency of MXene for the removal of uremic toxins could be attributed to synergistic effects of physical/chemical adsorption, electrostatic interaction surface of 2D MXene, and transformation of protein secondary structure. 2D MXene materials could be used as a new hemoperfusion sorbent with ultrahigh efficiency for removing uremic toxins during the treatment of kidney disease. |
| first_indexed | 2024-03-10T23:29:51Z |
| format | Article |
| id | doaj.art-8baedbd2b5804e4592b364aeeba8a885 |
| institution | Directory Open Access Journal |
| issn | 2352-8478 |
| language | English |
| last_indexed | 2024-03-10T23:29:51Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materiomics |
| spelling | doaj.art-8baedbd2b5804e4592b364aeeba8a8852023-11-19T04:35:01ZengElsevierJournal of Materiomics2352-84782023-11-019611291140MXene: An efficient hemoperfusion sorbent for the removal of uremic toxinsTianyi Wang0Wei Gu1Lu Yu2Xin Guo3Jian Yang4Xiaoyu Sun5Jun Guan6Lin Zhou7Chengyin Wang8Hang Yao9Xiuyun Zhang10Guoxiu Wang11College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu Province, ChinaCollege of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu Province, ChinaCollege of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu Province, ChinaCentre for Clean Energy Technology, School of Mathematics and Physics, Faculty of Science, University of Technology Sydney, Broadway, Sydney, NSW2007, AustraliaCollege of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu Province, ChinaCollege of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu Province, ChinaClinical Medical College, Su Bei People's Hospital, Yangzhou University, Yangzhou, 225000, Jiangsu Province, ChinaClinical Medical College, Su Bei People's Hospital, Yangzhou University, Yangzhou, 225000, Jiangsu Province, ChinaCollege of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu Province, ChinaCollege of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225000, Jiangsu Province, China; Corresponding author.College of Physical Science and Technology, Yangzhou University, Yangzhou, 225000, Jiangsu Province, China; Corresponding author.Centre for Clean Energy Technology, School of Mathematics and Physics, Faculty of Science, University of Technology Sydney, Broadway, Sydney, NSW2007, Australia; Corresponding author.MXene, a family of two-dimensional (2D) transition metal carbides and nitrides have attracted extensive interests for many biochemical applications, including tumour elimination, biosensors, and magnetic resonance imaging (MRI). In this article, we firstly discovered that Ti3C2Tx MXene exhibited a highly efficient adsorption capability as hemoperfusion absorbent towards middle-molecular mass and protein bound uremic toxins in the end stage of renal disease (ESRD) treatment. Molecular scale investigations reveal that the high efficiency of MXene for the removal of uremic toxins could be attributed to synergistic effects of physical/chemical adsorption, electrostatic interaction surface of 2D MXene, and transformation of protein secondary structure. 2D MXene materials could be used as a new hemoperfusion sorbent with ultrahigh efficiency for removing uremic toxins during the treatment of kidney disease.http://www.sciencedirect.com/science/article/pii/S23528478230012232D materialsMXeneHemoperfusionMiddle molecular weight toxinProtein bound toxinAdsorption |
| spellingShingle | Tianyi Wang Wei Gu Lu Yu Xin Guo Jian Yang Xiaoyu Sun Jun Guan Lin Zhou Chengyin Wang Hang Yao Xiuyun Zhang Guoxiu Wang MXene: An efficient hemoperfusion sorbent for the removal of uremic toxins Journal of Materiomics 2D materials MXene Hemoperfusion Middle molecular weight toxin Protein bound toxin Adsorption |
| title | MXene: An efficient hemoperfusion sorbent for the removal of uremic toxins |
| title_full | MXene: An efficient hemoperfusion sorbent for the removal of uremic toxins |
| title_fullStr | MXene: An efficient hemoperfusion sorbent for the removal of uremic toxins |
| title_full_unstemmed | MXene: An efficient hemoperfusion sorbent for the removal of uremic toxins |
| title_short | MXene: An efficient hemoperfusion sorbent for the removal of uremic toxins |
| title_sort | mxene an efficient hemoperfusion sorbent for the removal of uremic toxins |
| topic | 2D materials MXene Hemoperfusion Middle molecular weight toxin Protein bound toxin Adsorption |
| url | http://www.sciencedirect.com/science/article/pii/S2352847823001223 |
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