Identification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severity
Abstract Background The ongoing pandemic of COVID-19 viruses takes its sole origin from the Wuhan Huanan seafood market, China. The first case was recorded as viral pneumonia and later became a worldwide pandemic (officially declared by WHO on March 11, 2020). Main body SARS-CoV-2 is an extremely in...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2021-04-01
|
| Series: | Bulletin of the National Research Centre |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42269-021-00540-y |
| _version_ | 1818827677872685056 |
|---|---|
| author | Ramakrishnan Veerabathiran Barath Ragunath Vaishak Kaviarasan Vajagathali Mohammed Shiek S. S. J. Ahmed |
| author_facet | Ramakrishnan Veerabathiran Barath Ragunath Vaishak Kaviarasan Vajagathali Mohammed Shiek S. S. J. Ahmed |
| author_sort | Ramakrishnan Veerabathiran |
| collection | DOAJ |
| description | Abstract Background The ongoing pandemic of COVID-19 viruses takes its sole origin from the Wuhan Huanan seafood market, China. The first case was recorded as viral pneumonia and later became a worldwide pandemic (officially declared by WHO on March 11, 2020). Main body SARS-CoV-2 is an extremely infectious and transferrable virus that develops severe conditions like respiratory syndrome, high blood pressure and weakens the immune system. Coronavirus falls under the Coronaviridae family and Beta coronavirus genus. Affected individuals will encounter problems starting with fever followed by severe complications like SARS, ARDS, and many others. These SARS-CoV and MERS-CoV enter the host cells by the endosomal pathway, and about 16 non-structural proteins are involved in assembling the viral RNA synthesis complex. They possess a positive-sense single-stranded RNA, and about four major genes are mainly associated with the development of ASRD, SARS, and other respiratory problems. Conclusion Susceptibility of these four major genes such as ACE2, IL-2, 7 and 10, TNF, and VEGF is associated with COVID-19. This highlights the identification of the above-mentioned genes that can be used as potential biomarkers for early diagnosis and targeted drug delivery for treating the SARS-CoV-2 neurological symptoms and reducing inflammation in the brain. |
| first_indexed | 2024-12-19T00:47:22Z |
| format | Article |
| id | doaj.art-8bb0140b85cb4cf4877db41173f14f9f |
| institution | Directory Open Access Journal |
| issn | 2522-8307 |
| language | English |
| last_indexed | 2024-12-19T00:47:22Z |
| publishDate | 2021-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bulletin of the National Research Centre |
| spelling | doaj.art-8bb0140b85cb4cf4877db41173f14f9f2022-12-21T20:44:14ZengSpringerOpenBulletin of the National Research Centre2522-83072021-04-0145111110.1186/s42269-021-00540-yIdentification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severityRamakrishnan Veerabathiran0Barath Ragunath1Vaishak Kaviarasan2Vajagathali Mohammed3Shiek S. S. J. Ahmed4Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI) Chettinad Academy of Research and Education (CARE)Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI) Chettinad Academy of Research and Education (CARE)Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI) Chettinad Academy of Research and Education (CARE)Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI) Chettinad Academy of Research and Education (CARE)Drug Discovery and Multi-Omics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI) Chettinad Academy of Research and Education (CARE)Abstract Background The ongoing pandemic of COVID-19 viruses takes its sole origin from the Wuhan Huanan seafood market, China. The first case was recorded as viral pneumonia and later became a worldwide pandemic (officially declared by WHO on March 11, 2020). Main body SARS-CoV-2 is an extremely infectious and transferrable virus that develops severe conditions like respiratory syndrome, high blood pressure and weakens the immune system. Coronavirus falls under the Coronaviridae family and Beta coronavirus genus. Affected individuals will encounter problems starting with fever followed by severe complications like SARS, ARDS, and many others. These SARS-CoV and MERS-CoV enter the host cells by the endosomal pathway, and about 16 non-structural proteins are involved in assembling the viral RNA synthesis complex. They possess a positive-sense single-stranded RNA, and about four major genes are mainly associated with the development of ASRD, SARS, and other respiratory problems. Conclusion Susceptibility of these four major genes such as ACE2, IL-2, 7 and 10, TNF, and VEGF is associated with COVID-19. This highlights the identification of the above-mentioned genes that can be used as potential biomarkers for early diagnosis and targeted drug delivery for treating the SARS-CoV-2 neurological symptoms and reducing inflammation in the brain.https://doi.org/10.1186/s42269-021-00540-ySARS-CoV-2GenesACE2InterleukinCytokines |
| spellingShingle | Ramakrishnan Veerabathiran Barath Ragunath Vaishak Kaviarasan Vajagathali Mohammed Shiek S. S. J. Ahmed Identification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severity Bulletin of the National Research Centre SARS-CoV-2 Genes ACE2 Interleukin Cytokines |
| title | Identification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severity |
| title_full | Identification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severity |
| title_fullStr | Identification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severity |
| title_full_unstemmed | Identification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severity |
| title_short | Identification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severity |
| title_sort | identification of selected genes associated with the sars cov 2 a therapeutic approach and disease severity |
| topic | SARS-CoV-2 Genes ACE2 Interleukin Cytokines |
| url | https://doi.org/10.1186/s42269-021-00540-y |
| work_keys_str_mv | AT ramakrishnanveerabathiran identificationofselectedgenesassociatedwiththesarscov2atherapeuticapproachanddiseaseseverity AT barathragunath identificationofselectedgenesassociatedwiththesarscov2atherapeuticapproachanddiseaseseverity AT vaishakkaviarasan identificationofselectedgenesassociatedwiththesarscov2atherapeuticapproachanddiseaseseverity AT vajagathalimohammed identificationofselectedgenesassociatedwiththesarscov2atherapeuticapproachanddiseaseseverity AT shiekssjahmed identificationofselectedgenesassociatedwiththesarscov2atherapeuticapproachanddiseaseseverity |