Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization Study
BackgroundHypertension may have some association with osteoporosis. This Mendelian randomization (MR) study aimed to explore the causal effect of blood pressure (BP) on bone mineral density (BMD), fall, and fracture.MethodsWe used the genome-wide association study (GWAS) summary data among 330,956 E...
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.716681/full |
| _version_ | 1818601493247295488 |
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| author | Bin He Lifeng Yin Muzi Zhang Qiong Lyu Zhengxue Quan Yunsheng Ou |
| author_facet | Bin He Lifeng Yin Muzi Zhang Qiong Lyu Zhengxue Quan Yunsheng Ou |
| author_sort | Bin He |
| collection | DOAJ |
| description | BackgroundHypertension may have some association with osteoporosis. This Mendelian randomization (MR) study aimed to explore the causal effect of blood pressure (BP) on bone mineral density (BMD), fall, and fracture.MethodsWe used the genome-wide association study (GWAS) summary data among 330,956 European-descent individuals to identify 107 single-nucleotide polymorphisms (SNPs) as the instrumental variables of BP. MR analyses of these instruments were performed on 53,236 European individuals for the association with forearm BMD (FA-BMD), femoral neck BMD (FN-BMD), and lumbar spine BMD (LS-BMD); 451,179 European individuals for fall susceptibility; and up to 1.2 million individuals from European descent for fracture. Conventional inverse variance weighted (IVW) method was adopted to obtain the causal estimates of BP on different outcomes, while weighted median, MR-egger, and MR pleiotropy residual sum and outlier (MR-PRESSO) test were used for sensitivity analyses.ResultsGenetically high pulse pressure (PP) could significantly improve FA-BMD (beta-estimate: 0.038, 95% confidence interval [CI]: 0.013 to 0.063, SE:0.013, P-value=0.003<Bonferroni correction P) in the IVW analysis, indicating that 1-SD increase in PP was associated with the improvement in FA-BMD levels by 0.038 g/cm2 (95% CI: 0.013 to 0.063). This positive finding was also confirmed by weighted-median analysis (beta-estimate: 0.034, 95% CI: 0.000 to 0.067, SE:0.017, P-value=0.046) and MR-Egger analysis (beta-estimate: 0.117, 95% CI: 0.026 to 0.208, SE:0.046, P-value=0.011). However, there was no remarkable MR association between BP and other outcomes (i.e., FN-BMD, LS-BMD, fall, and fracture).ConclusionsOur findings reveal a potentially causal relationship between high PP and improved FA-BMD, which may provide new sights for the treatment of osteoporosis. |
| first_indexed | 2024-12-16T12:52:15Z |
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| id | doaj.art-8bb12517279f48749462958956084ad6 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-16T12:52:15Z |
| publishDate | 2021-08-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-8bb12517279f48749462958956084ad62022-12-21T22:31:07ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-08-011210.3389/fendo.2021.716681716681Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization StudyBin He0Lifeng Yin1Muzi Zhang2Qiong Lyu3Zhengxue Quan4Yunsheng Ou5Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of General Practice, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaBackgroundHypertension may have some association with osteoporosis. This Mendelian randomization (MR) study aimed to explore the causal effect of blood pressure (BP) on bone mineral density (BMD), fall, and fracture.MethodsWe used the genome-wide association study (GWAS) summary data among 330,956 European-descent individuals to identify 107 single-nucleotide polymorphisms (SNPs) as the instrumental variables of BP. MR analyses of these instruments were performed on 53,236 European individuals for the association with forearm BMD (FA-BMD), femoral neck BMD (FN-BMD), and lumbar spine BMD (LS-BMD); 451,179 European individuals for fall susceptibility; and up to 1.2 million individuals from European descent for fracture. Conventional inverse variance weighted (IVW) method was adopted to obtain the causal estimates of BP on different outcomes, while weighted median, MR-egger, and MR pleiotropy residual sum and outlier (MR-PRESSO) test were used for sensitivity analyses.ResultsGenetically high pulse pressure (PP) could significantly improve FA-BMD (beta-estimate: 0.038, 95% confidence interval [CI]: 0.013 to 0.063, SE:0.013, P-value=0.003<Bonferroni correction P) in the IVW analysis, indicating that 1-SD increase in PP was associated with the improvement in FA-BMD levels by 0.038 g/cm2 (95% CI: 0.013 to 0.063). This positive finding was also confirmed by weighted-median analysis (beta-estimate: 0.034, 95% CI: 0.000 to 0.067, SE:0.017, P-value=0.046) and MR-Egger analysis (beta-estimate: 0.117, 95% CI: 0.026 to 0.208, SE:0.046, P-value=0.011). However, there was no remarkable MR association between BP and other outcomes (i.e., FN-BMD, LS-BMD, fall, and fracture).ConclusionsOur findings reveal a potentially causal relationship between high PP and improved FA-BMD, which may provide new sights for the treatment of osteoporosis.https://www.frontiersin.org/articles/10.3389/fendo.2021.716681/fullblood pressurebone mineral densityfallfractureMendelian randomization study |
| spellingShingle | Bin He Lifeng Yin Muzi Zhang Qiong Lyu Zhengxue Quan Yunsheng Ou Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization Study Frontiers in Endocrinology blood pressure bone mineral density fall fracture Mendelian randomization study |
| title | Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization Study |
| title_full | Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization Study |
| title_fullStr | Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization Study |
| title_full_unstemmed | Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization Study |
| title_short | Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization Study |
| title_sort | causal effect of blood pressure on bone mineral density and fracture a mendelian randomization study |
| topic | blood pressure bone mineral density fall fracture Mendelian randomization study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.716681/full |
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