Established and Evolving Roles of the Multifunctional Non-POU Domain-Containing Octamer-Binding Protein (NonO) and Splicing Factor Proline- and Glutamine-Rich (SFPQ)
It has been more than three decades since the discovery of multifunctional factors, the Non-POU-Domain-Containing Octamer-Binding Protein, NonO, and the Splicing Factor Proline- and Glutamine-Rich, SFPQ. Some of their functions, including their participation in transcriptional and posttranscriptiona...
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MDPI AG
2024-01-01
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| Series: | Journal of Developmental Biology |
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| Online Access: | https://www.mdpi.com/2221-3759/12/1/3 |
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| author | Danyang Yu Ching-Jung Huang Haley O. Tucker |
| author_facet | Danyang Yu Ching-Jung Huang Haley O. Tucker |
| author_sort | Danyang Yu |
| collection | DOAJ |
| description | It has been more than three decades since the discovery of multifunctional factors, the Non-POU-Domain-Containing Octamer-Binding Protein, NonO, and the Splicing Factor Proline- and Glutamine-Rich, SFPQ. Some of their functions, including their participation in transcriptional and posttranscriptional regulation as well as their contribution to paraspeckle subnuclear body organization, have been well documented. In this review, we focus on several other established roles of NonO and SFPQ, including their participation in the cell cycle, nonhomologous end-joining (NHEJ), homologous recombination (HR), telomere stability, childhood birth defects and cancer. In each of these contexts, the absence or malfunction of either or both NonO and SFPQ leads to either genome instability, tumor development or mental impairment. |
| first_indexed | 2024-04-24T18:08:14Z |
| format | Article |
| id | doaj.art-8bb20850593f483c974e4e31d0c07e06 |
| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-04-24T18:08:14Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
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| series | Journal of Developmental Biology |
| spelling | doaj.art-8bb20850593f483c974e4e31d0c07e062024-03-27T13:48:34ZengMDPI AGJournal of Developmental Biology2221-37592024-01-01121310.3390/jdb12010003Established and Evolving Roles of the Multifunctional Non-POU Domain-Containing Octamer-Binding Protein (NonO) and Splicing Factor Proline- and Glutamine-Rich (SFPQ)Danyang Yu0Ching-Jung Huang1Haley O. Tucker2Department of Biology, New York University in Shanghai, Shanghai 200122, ChinaDepartment of Biology, New York University in Shanghai, Shanghai 200122, ChinaMolecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station A5000, Austin, TX 78712, USAIt has been more than three decades since the discovery of multifunctional factors, the Non-POU-Domain-Containing Octamer-Binding Protein, NonO, and the Splicing Factor Proline- and Glutamine-Rich, SFPQ. Some of their functions, including their participation in transcriptional and posttranscriptional regulation as well as their contribution to paraspeckle subnuclear body organization, have been well documented. In this review, we focus on several other established roles of NonO and SFPQ, including their participation in the cell cycle, nonhomologous end-joining (NHEJ), homologous recombination (HR), telomere stability, childhood birth defects and cancer. In each of these contexts, the absence or malfunction of either or both NonO and SFPQ leads to either genome instability, tumor development or mental impairment.https://www.mdpi.com/2221-3759/12/1/3NonO/p54nrbSFPQ/PSFDNA damage responseATR/ATMcell cyclecheckpoint control |
| spellingShingle | Danyang Yu Ching-Jung Huang Haley O. Tucker Established and Evolving Roles of the Multifunctional Non-POU Domain-Containing Octamer-Binding Protein (NonO) and Splicing Factor Proline- and Glutamine-Rich (SFPQ) Journal of Developmental Biology NonO/p54nrb SFPQ/PSF DNA damage response ATR/ATM cell cycle checkpoint control |
| title | Established and Evolving Roles of the Multifunctional Non-POU Domain-Containing Octamer-Binding Protein (NonO) and Splicing Factor Proline- and Glutamine-Rich (SFPQ) |
| title_full | Established and Evolving Roles of the Multifunctional Non-POU Domain-Containing Octamer-Binding Protein (NonO) and Splicing Factor Proline- and Glutamine-Rich (SFPQ) |
| title_fullStr | Established and Evolving Roles of the Multifunctional Non-POU Domain-Containing Octamer-Binding Protein (NonO) and Splicing Factor Proline- and Glutamine-Rich (SFPQ) |
| title_full_unstemmed | Established and Evolving Roles of the Multifunctional Non-POU Domain-Containing Octamer-Binding Protein (NonO) and Splicing Factor Proline- and Glutamine-Rich (SFPQ) |
| title_short | Established and Evolving Roles of the Multifunctional Non-POU Domain-Containing Octamer-Binding Protein (NonO) and Splicing Factor Proline- and Glutamine-Rich (SFPQ) |
| title_sort | established and evolving roles of the multifunctional non pou domain containing octamer binding protein nono and splicing factor proline and glutamine rich sfpq |
| topic | NonO/p54nrb SFPQ/PSF DNA damage response ATR/ATM cell cycle checkpoint control |
| url | https://www.mdpi.com/2221-3759/12/1/3 |
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