Quincke-edema induced by chlorpromazine: About two cases
Introduction Quincke-edema has been specifically associated with using certain drugs including chlorpromazine as detailed through two clinical cases. Objectives Illustration of two clinical cases about angioedema induced by Chlorpromazine. Methods We reviewed clinical data from two patients wh...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933821012888/type/journal_article |
| _version_ | 1827754894206959616 |
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| author | S. Brahim W. Bouali M. Henia A. Abid L. Zarrouk |
| author_facet | S. Brahim W. Bouali M. Henia A. Abid L. Zarrouk |
| author_sort | S. Brahim |
| collection | DOAJ |
| description |
Introduction
Quincke-edema has been specifically associated with using certain drugs including chlorpromazine as detailed through two clinical cases.
Objectives
Illustration of two clinical cases about angioedema induced by Chlorpromazine.
Methods
We reviewed clinical data from two patients who committed a suicide attempt and then transferred to the psychiatry department after their somatic stabilization: the first was 27-year-old followed in psychiatry since childhood for intellectual deficiency and admitted to the emergency department for the suicide attempt by taking 14 tablets of chlorpromazine 100 mg and the second was a 20-year-old patient, admitted to the emergency department for suicide attempt by Raticid.
Results
The first patient presented a delusional persecution-themed syndrome with auditory hallucinations. Therefore, he was initially put on injectable treatment with Haloperidol 15mg and Diazepam 30mg then oral relay after 48h by Risperidone 4 mg and Chlorpromazine 200 mg. On the fourthday of his hospitalization, he presented a Quincke edema without laryngeal impairment. We stopped chlorpromazine and eliminated the other causes of this edema, resulting in a gradual regression of symptomatology. The second patient was put on chlorpromazine. On the second day, the patient presented a Quincke edema without laryngeal impairment. Somatic examination and biological exploration did not reveal any abnormalities. We stopped chlorpromazine and put the patient on Dexamethasone 3 days in a row resulting in a good outcome.
Conclusions
These two cases identified a Quincke-edema reaction associated with the use of Chlorpromazine, this complication can lead to life-threatening manifestations and warrants greater awareness of the potential for recurrence.
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| first_indexed | 2024-03-11T07:56:54Z |
| format | Article |
| id | doaj.art-8bb299a56bbb46e494261e38509eff5b |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:56:54Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-8bb299a56bbb46e494261e38509eff5b2023-11-17T05:05:38ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S482S48210.1192/j.eurpsy.2021.1288Quincke-edema induced by chlorpromazine: About two casesS. Brahim0W. Bouali1M. Henia2A. Abid3L. Zarrouk4Psychiatry, University Hospital of Mahdia, Tunisia., chebba, TunisiaDepartment Of Psychiatry, University Hospital Of Mahdia, Tunisia., Psychiatry, Mahdia, TunisiaDepartment Of Psychiatry, University Hospital Of Mahdia, Tunisia., Psychiatry, Mahdia, TunisiaAnesthesia, University Hospital of Mahdia, Tunisia., mahdia, TunisiaDepartment Of Psychiatry, University Hospital Of Mahdia, Tunisia., Psychiatry, Mahdia, Tunisia Introduction Quincke-edema has been specifically associated with using certain drugs including chlorpromazine as detailed through two clinical cases. Objectives Illustration of two clinical cases about angioedema induced by Chlorpromazine. Methods We reviewed clinical data from two patients who committed a suicide attempt and then transferred to the psychiatry department after their somatic stabilization: the first was 27-year-old followed in psychiatry since childhood for intellectual deficiency and admitted to the emergency department for the suicide attempt by taking 14 tablets of chlorpromazine 100 mg and the second was a 20-year-old patient, admitted to the emergency department for suicide attempt by Raticid. Results The first patient presented a delusional persecution-themed syndrome with auditory hallucinations. Therefore, he was initially put on injectable treatment with Haloperidol 15mg and Diazepam 30mg then oral relay after 48h by Risperidone 4 mg and Chlorpromazine 200 mg. On the fourthday of his hospitalization, he presented a Quincke edema without laryngeal impairment. We stopped chlorpromazine and eliminated the other causes of this edema, resulting in a gradual regression of symptomatology. The second patient was put on chlorpromazine. On the second day, the patient presented a Quincke edema without laryngeal impairment. Somatic examination and biological exploration did not reveal any abnormalities. We stopped chlorpromazine and put the patient on Dexamethasone 3 days in a row resulting in a good outcome. Conclusions These two cases identified a Quincke-edema reaction associated with the use of Chlorpromazine, this complication can lead to life-threatening manifestations and warrants greater awareness of the potential for recurrence. https://www.cambridge.org/core/product/identifier/S0924933821012888/type/journal_articlechlorpromazineclinical casePharmacologyQuincke-edema |
| spellingShingle | S. Brahim W. Bouali M. Henia A. Abid L. Zarrouk Quincke-edema induced by chlorpromazine: About two cases European Psychiatry chlorpromazine clinical case Pharmacology Quincke-edema |
| title | Quincke-edema induced by chlorpromazine: About two cases |
| title_full | Quincke-edema induced by chlorpromazine: About two cases |
| title_fullStr | Quincke-edema induced by chlorpromazine: About two cases |
| title_full_unstemmed | Quincke-edema induced by chlorpromazine: About two cases |
| title_short | Quincke-edema induced by chlorpromazine: About two cases |
| title_sort | quincke edema induced by chlorpromazine about two cases |
| topic | chlorpromazine clinical case Pharmacology Quincke-edema |
| url | https://www.cambridge.org/core/product/identifier/S0924933821012888/type/journal_article |
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