Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the <italic toggle="yes">Coxiella</italic>-Containing Vacuole

Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the <italic toggle="yes">Coxiella</italic>-Containing Vacuole

ABSTRACT Coxiella burnetii replicates in an acidified lysosome-derived vacuole. Biogenesis of the Coxiella-containing vacuole (CCV) requires bacterial effector proteins delivered into host cells by the Dot/Icm secretion system. Genetic and cell biological analysis revealed that an effector protein c...

Full description

Bibliographic Details
Main Authors: Lara J. Kohler, Shawna R. Reed, Shireen A. Sarraf, David D. Arteaga, Hayley J. Newton, Craig R. Roy
Format: Article
Language:English
Published: American Society for Microbiology 2016-09-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.01127-16

Similar Items

Similar Items