Immunomodulatory effects of Blaps rynchopetera extract
ABSTRACT Purpose: To explore the potential immunomodulatory effects of total extract and different polar parts from Blaps rynchopetera Fairmaire. Methods: Phagocytic activity was evaluated by neutral red assay, and the effect of the immune function was investigated by normal and immunocompromised...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2022-05-01
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| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502022000200204&lng=en&tlng=en |
| _version_ | 1818186940123447296 |
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| author | Di Meng Yinhe Yang Longxing Li Xiaoli Qian Qi Wang Jinglei Xu Hairong Zhao Heng Liu Huai Xiao Zhongtao Ding |
| author_facet | Di Meng Yinhe Yang Longxing Li Xiaoli Qian Qi Wang Jinglei Xu Hairong Zhao Heng Liu Huai Xiao Zhongtao Ding |
| author_sort | Di Meng |
| collection | DOAJ |
| description | ABSTRACT Purpose: To explore the potential immunomodulatory effects of total extract and different polar parts from Blaps rynchopetera Fairmaire. Methods: Phagocytic activity was evaluated by neutral red assay, and the effect of the immune function was investigated by normal and immunocompromised mice models. Results: In vitro, total extract, as well as chloroform, ethyl acetate, n-butanol and water fractions could individually enhance the phagocytic ability of mouse peritoneal macrophages; in addition, chloroform and ethyl acetate fractions had an increasing tendency when combined stimulation with lipopolysaccharide (LPS). In vivo, ethyl acetate fraction (EAF) could enhance the immune organ index, increase the serum hemolysin level and peripheral blood immune cells of immunocompromised mice, while for normal mice, the effect was inconspicuous. Conclusions: Blaps rynchopetera extracts had noteworthy immunomodulatory effect, especially for individuals with immune disorders. |
| first_indexed | 2024-12-11T23:03:07Z |
| format | Article |
| id | doaj.art-8bb5a98e86524cc1bf853ca48db01685 |
| institution | Directory Open Access Journal |
| issn | 1678-2674 |
| language | English |
| last_indexed | 2024-12-11T23:03:07Z |
| publishDate | 2022-05-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-8bb5a98e86524cc1bf853ca48db016852022-12-22T00:47:01ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira1678-26742022-05-0137210.1590/acb370205Immunomodulatory effects of Blaps rynchopetera extractDi Menghttps://orcid.org/0000-0001-6218-2151Yinhe Yanghttps://orcid.org/0000-0003-2792-8274Longxing Lihttps://orcid.org/0000-0003-3097-3543Xiaoli Qianhttps://orcid.org/0000-0002-0614-9696Qi Wanghttps://orcid.org/0000-0001-9863-560XJinglei Xuhttps://orcid.org/0000-0003-2101-4631Hairong Zhaohttps://orcid.org/0000-0003-0000-8136Heng Liuhttps://orcid.org/0000-0003-3937-4985Huai Xiaohttps://orcid.org/0000-0003-3427-2197Zhongtao Dinghttps://orcid.org/0000-0002-5058-5663ABSTRACT Purpose: To explore the potential immunomodulatory effects of total extract and different polar parts from Blaps rynchopetera Fairmaire. Methods: Phagocytic activity was evaluated by neutral red assay, and the effect of the immune function was investigated by normal and immunocompromised mice models. Results: In vitro, total extract, as well as chloroform, ethyl acetate, n-butanol and water fractions could individually enhance the phagocytic ability of mouse peritoneal macrophages; in addition, chloroform and ethyl acetate fractions had an increasing tendency when combined stimulation with lipopolysaccharide (LPS). In vivo, ethyl acetate fraction (EAF) could enhance the immune organ index, increase the serum hemolysin level and peripheral blood immune cells of immunocompromised mice, while for normal mice, the effect was inconspicuous. Conclusions: Blaps rynchopetera extracts had noteworthy immunomodulatory effect, especially for individuals with immune disorders.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502022000200204&lng=en&tlng=enInsectMacrophagesImmunocompromised HostMice |
| spellingShingle | Di Meng Yinhe Yang Longxing Li Xiaoli Qian Qi Wang Jinglei Xu Hairong Zhao Heng Liu Huai Xiao Zhongtao Ding Immunomodulatory effects of Blaps rynchopetera extract Acta Cirúrgica Brasileira Insect Macrophages Immunocompromised Host Mice |
| title | Immunomodulatory effects of Blaps rynchopetera extract |
| title_full | Immunomodulatory effects of Blaps rynchopetera extract |
| title_fullStr | Immunomodulatory effects of Blaps rynchopetera extract |
| title_full_unstemmed | Immunomodulatory effects of Blaps rynchopetera extract |
| title_short | Immunomodulatory effects of Blaps rynchopetera extract |
| title_sort | immunomodulatory effects of blaps rynchopetera extract |
| topic | Insect Macrophages Immunocompromised Host Mice |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502022000200204&lng=en&tlng=en |
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