Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance
Newly formed microvessels in most solid tumors show an abnormal morphology and thus do not fulfil the metabolic demands of the growing tumor mass. Due to the chaotic and heterogeneous tumor microcirculation, a hostile tumor microenvironment develops, that is characterized inter alia by local hypoxia...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/6/2/813 |
| _version_ | 1797766180768841728 |
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| author | Gabriele Multhoff Jürgen Radons Peter Vaupel |
| author_facet | Gabriele Multhoff Jürgen Radons Peter Vaupel |
| author_sort | Gabriele Multhoff |
| collection | DOAJ |
| description | Newly formed microvessels in most solid tumors show an abnormal morphology and thus do not fulfil the metabolic demands of the growing tumor mass. Due to the chaotic and heterogeneous tumor microcirculation, a hostile tumor microenvironment develops, that is characterized inter alia by local hypoxia, which in turn can stimulate the HIF-system. The latter can lead to tumor progression and may be involved in hypoxia-mediated radioresistance of tumor cells. Herein, cellular and molecular mechanisms in tumor angiogenesis are discussed that, among others, might impact hypoxia-related radioresistance. |
| first_indexed | 2024-03-12T20:21:31Z |
| format | Article |
| id | doaj.art-8bb673e7490342b5841bcde296e463e8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T20:21:31Z |
| publishDate | 2014-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8bb673e7490342b5841bcde296e463e82023-08-02T00:55:56ZengMDPI AGCancers2072-66942014-04-016281382810.3390/cancers6020813cancers6020813Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated RadioresistanceGabriele Multhoff0Jürgen Radons1Peter Vaupel2Department of Radiotherapy and Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675 Munich, GermanyGmbH, Munich, Ismaningerstr. 22, 81675 Munich, GermanyDepartment of Radiotherapy and Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675 Munich, GermanyNewly formed microvessels in most solid tumors show an abnormal morphology and thus do not fulfil the metabolic demands of the growing tumor mass. Due to the chaotic and heterogeneous tumor microcirculation, a hostile tumor microenvironment develops, that is characterized inter alia by local hypoxia, which in turn can stimulate the HIF-system. The latter can lead to tumor progression and may be involved in hypoxia-mediated radioresistance of tumor cells. Herein, cellular and molecular mechanisms in tumor angiogenesis are discussed that, among others, might impact hypoxia-related radioresistance.http://www.mdpi.com/2072-6694/6/2/813tumor angiogenesistumor microcirculationtumor hypoxiahypoxia-inducible factor (HIF)radioresistancehypoxia modifiers |
| spellingShingle | Gabriele Multhoff Jürgen Radons Peter Vaupel Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance Cancers tumor angiogenesis tumor microcirculation tumor hypoxia hypoxia-inducible factor (HIF) radioresistance hypoxia modifiers |
| title | Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance |
| title_full | Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance |
| title_fullStr | Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance |
| title_full_unstemmed | Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance |
| title_short | Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance |
| title_sort | critical role of aberrant angiogenesis in the development of tumor hypoxia and associated radioresistance |
| topic | tumor angiogenesis tumor microcirculation tumor hypoxia hypoxia-inducible factor (HIF) radioresistance hypoxia modifiers |
| url | http://www.mdpi.com/2072-6694/6/2/813 |
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