Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance

Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance

Newly formed microvessels in most solid tumors show an abnormal morphology and thus do not fulfil the metabolic demands of the growing tumor mass. Due to the chaotic and heterogeneous tumor microcirculation, a hostile tumor microenvironment develops, that is characterized inter alia by local hypoxia...

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Bibliographic Details
Main Authors: Gabriele Multhoff, Jürgen Radons, Peter Vaupel
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Cancers
Subjects:
tumor angiogenesis
tumor microcirculation
tumor hypoxia
hypoxia-inducible factor (HIF)
radioresistance
hypoxia modifiers
Online Access:http://www.mdpi.com/2072-6694/6/2/813

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