An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli
Colistin, the last resort for multidrug and extensively drug-resistant bacterial infection treatment, was reintroduced after being avoided in clinical settings from the 1970s to the 1990s because of its high toxicity. Colistin is considered a crucial treatment option for Acinetobacter baumannii and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.882236/full |
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| author | Piyatip Khuntayaporn Piyatip Khuntayaporn Krit Thirapanmethee Krit Thirapanmethee Mullika Traidej Chomnawang Mullika Traidej Chomnawang |
| author_facet | Piyatip Khuntayaporn Piyatip Khuntayaporn Krit Thirapanmethee Krit Thirapanmethee Mullika Traidej Chomnawang Mullika Traidej Chomnawang |
| author_sort | Piyatip Khuntayaporn |
| collection | DOAJ |
| description | Colistin, the last resort for multidrug and extensively drug-resistant bacterial infection treatment, was reintroduced after being avoided in clinical settings from the 1970s to the 1990s because of its high toxicity. Colistin is considered a crucial treatment option for Acinetobacter baumannii and Pseudomonas aeruginosa, which are listed as critical priority pathogens for new antibiotics by the World Health Organization. The resistance mechanisms of colistin are considered to be chromosomally encoded, and no horizontal transfer has been reported. Nevertheless, in November 2015, a transmissible resistance mechanism of colistin, called mobile colistin resistance (MCR), was discovered. Up to ten families with MCR and more than 100 variants of Gram-negative bacteria have been reported worldwide. Even though few have been reported from Acinetobacter spp. and Pseudomonas spp., it is important to closely monitor the epidemiology of mcr genes in these pathogens. Therefore, this review focuses on the most recent update on colistin resistance and the epidemiology of mcr genes among non-fermentative Gram-negative bacilli, especially Acinetobacter spp. and P. aeruginosa. |
| first_indexed | 2024-04-12T14:23:19Z |
| format | Article |
| id | doaj.art-8bb6bf8646ec442f94aaf4385a46cdcb |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-12T14:23:19Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-8bb6bf8646ec442f94aaf4385a46cdcb2022-12-22T03:29:30ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-06-011210.3389/fcimb.2022.882236882236An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative BacilliPiyatip Khuntayaporn0Piyatip Khuntayaporn1Krit Thirapanmethee2Krit Thirapanmethee3Mullika Traidej Chomnawang4Mullika Traidej Chomnawang5Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, ThailandAntimicrobial Resistance Interdisciplinary Group (AmRIG), Faculty of Pharmacy, Mahidol University, Bangkok, ThailandDepartment of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, ThailandAntimicrobial Resistance Interdisciplinary Group (AmRIG), Faculty of Pharmacy, Mahidol University, Bangkok, ThailandDepartment of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, ThailandAntimicrobial Resistance Interdisciplinary Group (AmRIG), Faculty of Pharmacy, Mahidol University, Bangkok, ThailandColistin, the last resort for multidrug and extensively drug-resistant bacterial infection treatment, was reintroduced after being avoided in clinical settings from the 1970s to the 1990s because of its high toxicity. Colistin is considered a crucial treatment option for Acinetobacter baumannii and Pseudomonas aeruginosa, which are listed as critical priority pathogens for new antibiotics by the World Health Organization. The resistance mechanisms of colistin are considered to be chromosomally encoded, and no horizontal transfer has been reported. Nevertheless, in November 2015, a transmissible resistance mechanism of colistin, called mobile colistin resistance (MCR), was discovered. Up to ten families with MCR and more than 100 variants of Gram-negative bacteria have been reported worldwide. Even though few have been reported from Acinetobacter spp. and Pseudomonas spp., it is important to closely monitor the epidemiology of mcr genes in these pathogens. Therefore, this review focuses on the most recent update on colistin resistance and the epidemiology of mcr genes among non-fermentative Gram-negative bacilli, especially Acinetobacter spp. and P. aeruginosa.https://www.frontiersin.org/articles/10.3389/fcimb.2022.882236/fullcolistin resistancemcr genesAcinetobacterPseudomonaspolymyxin |
| spellingShingle | Piyatip Khuntayaporn Piyatip Khuntayaporn Krit Thirapanmethee Krit Thirapanmethee Mullika Traidej Chomnawang Mullika Traidej Chomnawang An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli Frontiers in Cellular and Infection Microbiology colistin resistance mcr genes Acinetobacter Pseudomonas polymyxin |
| title | An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli |
| title_full | An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli |
| title_fullStr | An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli |
| title_full_unstemmed | An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli |
| title_short | An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli |
| title_sort | update of mobile colistin resistance in non fermentative gram negative bacilli |
| topic | colistin resistance mcr genes Acinetobacter Pseudomonas polymyxin |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.882236/full |
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