Impact of Particles on Pulmonary Endothelial Cells
According to the WHO, air quality affects around 40 million people, contributing to around 21,000 premature deaths per year. Severe respiratory diseases, such as asthma and chronic obstructive pulmonary disorder, can be promoted by air pollution, which has already been documented; this is one of the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/10/6/312 |
| _version_ | 1797481841845862400 |
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| author | Marina Almeida-Silva Jéssica Cardoso Catarina Alemão Sara Santos Ana Monteiro Vítor Manteigas Ana Marques-Ramos |
| author_facet | Marina Almeida-Silva Jéssica Cardoso Catarina Alemão Sara Santos Ana Monteiro Vítor Manteigas Ana Marques-Ramos |
| author_sort | Marina Almeida-Silva |
| collection | DOAJ |
| description | According to the WHO, air quality affects around 40 million people, contributing to around 21,000 premature deaths per year. Severe respiratory diseases, such as asthma and chronic obstructive pulmonary disorder, can be promoted by air pollution, which has already been documented; this is one of the reasons why air quality is a very relevant factor for human health and well-being. Aerosols are an aggregation of solid or liquid particles dispersed in the air and can be found in the form of dust or fumes. Aerosols can be easily inhaled or absorbed by the skin, which can lead to adverse health effects according to their sizes that range from the nanometre to the millimetre scale. Based on the PRISMA methodology and using the Rayyan QCRI platform, it was possible to assess more than four hundred research articles. This systematic review study aimed to understand the impact of particles on pulmonary endothelial cells, namely particulate matter in different sizes, cigarette smoke, diesel exhaust particles and carbon black. The main conclusions were that particles induce multiple health effects on endothelial cells, namely endothelial dysfunction, which can lead to apoptosis and necrosis, and it may also cause necroptosis in lung structure. |
| first_indexed | 2024-03-09T22:20:19Z |
| format | Article |
| id | doaj.art-8bb6ff06faf04213915eeff75a4dd147 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T22:20:19Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-8bb6ff06faf04213915eeff75a4dd1472023-11-23T19:16:09ZengMDPI AGToxics2305-63042022-06-0110631210.3390/toxics10060312Impact of Particles on Pulmonary Endothelial CellsMarina Almeida-Silva0Jéssica Cardoso1Catarina Alemão2Sara Santos3Ana Monteiro4Vítor Manteigas5Ana Marques-Ramos6HTRC-Health & Technology Research Center, ESTeSL—Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, 1990-096 Lisbon, PortugalHTRC-Health & Technology Research Center, ESTeSL—Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, 1990-096 Lisbon, PortugalHTRC-Health & Technology Research Center, ESTeSL—Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, 1990-096 Lisbon, PortugalHTRC-Health & Technology Research Center, ESTeSL—Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, 1990-096 Lisbon, PortugalHTRC-Health & Technology Research Center, ESTeSL—Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, 1990-096 Lisbon, PortugalHTRC-Health & Technology Research Center, ESTeSL—Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, 1990-096 Lisbon, PortugalHTRC-Health & Technology Research Center, ESTeSL—Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, 1990-096 Lisbon, PortugalAccording to the WHO, air quality affects around 40 million people, contributing to around 21,000 premature deaths per year. Severe respiratory diseases, such as asthma and chronic obstructive pulmonary disorder, can be promoted by air pollution, which has already been documented; this is one of the reasons why air quality is a very relevant factor for human health and well-being. Aerosols are an aggregation of solid or liquid particles dispersed in the air and can be found in the form of dust or fumes. Aerosols can be easily inhaled or absorbed by the skin, which can lead to adverse health effects according to their sizes that range from the nanometre to the millimetre scale. Based on the PRISMA methodology and using the Rayyan QCRI platform, it was possible to assess more than four hundred research articles. This systematic review study aimed to understand the impact of particles on pulmonary endothelial cells, namely particulate matter in different sizes, cigarette smoke, diesel exhaust particles and carbon black. The main conclusions were that particles induce multiple health effects on endothelial cells, namely endothelial dysfunction, which can lead to apoptosis and necrosis, and it may also cause necroptosis in lung structure.https://www.mdpi.com/2305-6304/10/6/312pulmonary endothelial cellsparticlesimpactexposurepollution |
| spellingShingle | Marina Almeida-Silva Jéssica Cardoso Catarina Alemão Sara Santos Ana Monteiro Vítor Manteigas Ana Marques-Ramos Impact of Particles on Pulmonary Endothelial Cells Toxics pulmonary endothelial cells particles impact exposure pollution |
| title | Impact of Particles on Pulmonary Endothelial Cells |
| title_full | Impact of Particles on Pulmonary Endothelial Cells |
| title_fullStr | Impact of Particles on Pulmonary Endothelial Cells |
| title_full_unstemmed | Impact of Particles on Pulmonary Endothelial Cells |
| title_short | Impact of Particles on Pulmonary Endothelial Cells |
| title_sort | impact of particles on pulmonary endothelial cells |
| topic | pulmonary endothelial cells particles impact exposure pollution |
| url | https://www.mdpi.com/2305-6304/10/6/312 |
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