Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier
Abstract Exosomes are membranous vesicles with a 30 to 150 nm diameter secreted by mesenchymal stem/stromal cells (MSCs) and other cells, such as immune cells and cancer cells. Exosomes convey proteins, bioactive lipids, and genetic components to recipient cells, such as microRNAs (miRNAs). Conseque...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01034-5 |
| _version_ | 1797865202529599488 |
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| author | Mohammad Hadi Gerami Roya Khorram Soheil Rasoolzadegan Saeid Mardpour Pooria Nakhaei Soheyla Hashemi Bashar Zuhair Talib Al-Naqeeb Amir Aminian Sahar Samimi |
| author_facet | Mohammad Hadi Gerami Roya Khorram Soheil Rasoolzadegan Saeid Mardpour Pooria Nakhaei Soheyla Hashemi Bashar Zuhair Talib Al-Naqeeb Amir Aminian Sahar Samimi |
| author_sort | Mohammad Hadi Gerami |
| collection | DOAJ |
| description | Abstract Exosomes are membranous vesicles with a 30 to 150 nm diameter secreted by mesenchymal stem/stromal cells (MSCs) and other cells, such as immune cells and cancer cells. Exosomes convey proteins, bioactive lipids, and genetic components to recipient cells, such as microRNAs (miRNAs). Consequently, they have been implicated in regulating intercellular communication mediators under physiological and pathological circumstances. Exosomes therapy as a cell-free approach bypasses many concerns regarding the therapeutic application of stem/stromal cells, including undesirable proliferation, heterogeneity, and immunogenic effects. Indeed, exosomes have become a promising strategy to treat human diseases, particularly bone- and joint-associated musculoskeletal disorders, because of their characteristics, such as potentiated stability in circulation, biocompatibility, low immunogenicity, and toxicity. In this light, a diversity of studies have indicated that inhibiting inflammation, inducing angiogenesis, provoking osteoblast and chondrocyte proliferation and migration, and negative regulation of matrix-degrading enzymes result in bone and cartilage recovery upon administration of MSCs-derived exosomes. Notwithstanding, insufficient quantity of isolated exosomes, lack of reliable potency test, and exosomes heterogeneity hurdle their application in clinics. Herein, we will deliver an outline respecting the advantages of MSCs-derived exosomes-based therapy in common bone- and joint-associated musculoskeletal disorders. Moreover, we will have a glimpse the underlying mechanism behind the MSCs-elicited therapeutic merits in these conditions. |
| first_indexed | 2024-04-09T23:05:22Z |
| format | Article |
| id | doaj.art-8bb8a3b04c9a415886d7625d62a32cc0 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-04-09T23:05:22Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-8bb8a3b04c9a415886d7625d62a32cc02023-03-22T10:46:27ZengBMCEuropean Journal of Medical Research2047-783X2023-02-0128111910.1186/s40001-023-01034-5Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontierMohammad Hadi Gerami0Roya Khorram1Soheil Rasoolzadegan2Saeid Mardpour3Pooria Nakhaei4Soheyla Hashemi5Bashar Zuhair Talib Al-Naqeeb6Amir Aminian7Sahar Samimi8Bone and Joint Diseases Research Center, Shiraz University of Medical SciencesBone and Joint Diseases Research Center, Department of Orthopedic Surgery, Shiraz University of Medical SciencesDepartment of Surgery, School of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Radiology, Imam Khomeini Hospital, Tehran University of Medical SciencesEndocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical SciencesObstetrician, Gynaecology & Infertility Department, Isfahan University of Medical SciencesAnesthesia Technology Department, Al-Turath University CollegeBone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical SciencesTehran University of Medical SciencesAbstract Exosomes are membranous vesicles with a 30 to 150 nm diameter secreted by mesenchymal stem/stromal cells (MSCs) and other cells, such as immune cells and cancer cells. Exosomes convey proteins, bioactive lipids, and genetic components to recipient cells, such as microRNAs (miRNAs). Consequently, they have been implicated in regulating intercellular communication mediators under physiological and pathological circumstances. Exosomes therapy as a cell-free approach bypasses many concerns regarding the therapeutic application of stem/stromal cells, including undesirable proliferation, heterogeneity, and immunogenic effects. Indeed, exosomes have become a promising strategy to treat human diseases, particularly bone- and joint-associated musculoskeletal disorders, because of their characteristics, such as potentiated stability in circulation, biocompatibility, low immunogenicity, and toxicity. In this light, a diversity of studies have indicated that inhibiting inflammation, inducing angiogenesis, provoking osteoblast and chondrocyte proliferation and migration, and negative regulation of matrix-degrading enzymes result in bone and cartilage recovery upon administration of MSCs-derived exosomes. Notwithstanding, insufficient quantity of isolated exosomes, lack of reliable potency test, and exosomes heterogeneity hurdle their application in clinics. Herein, we will deliver an outline respecting the advantages of MSCs-derived exosomes-based therapy in common bone- and joint-associated musculoskeletal disorders. Moreover, we will have a glimpse the underlying mechanism behind the MSCs-elicited therapeutic merits in these conditions.https://doi.org/10.1186/s40001-023-01034-5Mesenchymal stem/stromal cells (MSCs)ExosomesMusculoskeletal disorders BoneCartilage |
| spellingShingle | Mohammad Hadi Gerami Roya Khorram Soheil Rasoolzadegan Saeid Mardpour Pooria Nakhaei Soheyla Hashemi Bashar Zuhair Talib Al-Naqeeb Amir Aminian Sahar Samimi Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier European Journal of Medical Research Mesenchymal stem/stromal cells (MSCs) Exosomes Musculoskeletal disorders Bone Cartilage |
| title | Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier |
| title_full | Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier |
| title_fullStr | Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier |
| title_full_unstemmed | Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier |
| title_short | Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier |
| title_sort | emerging role of mesenchymal stem stromal cells mscs and mscs derived exosomes in bone and joint associated musculoskeletal disorders a new frontier |
| topic | Mesenchymal stem/stromal cells (MSCs) Exosomes Musculoskeletal disorders Bone Cartilage |
| url | https://doi.org/10.1186/s40001-023-01034-5 |
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