The prognostic value of amplitude-integrated EEG in full-term neonates with seizures.
Neonatal seizures pose a high risk for adverse outcome in survived infants. While the prognostic value of amplitude-integrated electroencephalogram (aEEG) is well established in neonates with encephalopathy and asphyxia, neonatal seizure studies focusing on the direct correlation between early aEEG...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3827298?pdf=render |
| _version_ | 1819056382230396928 |
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| author | Dandan Zhang Haiyan Ding Lili Liu Xinlin Hou Guoyu Sun Lei Li Yunzhe Liu Congle Zhou Ruolei Gu Yuejia Luo |
| author_facet | Dandan Zhang Haiyan Ding Lili Liu Xinlin Hou Guoyu Sun Lei Li Yunzhe Liu Congle Zhou Ruolei Gu Yuejia Luo |
| author_sort | Dandan Zhang |
| collection | DOAJ |
| description | Neonatal seizures pose a high risk for adverse outcome in survived infants. While the prognostic value of amplitude-integrated electroencephalogram (aEEG) is well established in neonates with encephalopathy and asphyxia, neonatal seizure studies focusing on the direct correlation between early aEEG measurement and subsequent neurologic outcome are scarce. In this study, the prognostic value of aEEG features was systematically analyzed in 143 full-term neonates to identify prognostic indicators of neurodevelopmental outcome. Neonatal aEEG features of background pattern, cyclicity, and seizure activity, as well as the etiology of neonatal seizures, were significantly associated with neurodevelopmental outcome at one year of age. aEEG background pattern was highly associated with neurologic outcomes (χ² = 116.9), followed by aEEG cyclicity (χ² = 87.2) and seizure etiology (χ² = 79.3). Multiple linear regression showed that the four predictors explained 71.2% of the variation in neurological outcome, with standardized β coefficients of 0.44, 0.24, 0.22, and 0.14 for the predictors of aEEG background pattern, cyclicity, etiology, and aEEG seizure activity, respectively. This clinically applicable scoring system based on etiology and three aEEG indices would allow pediatricians to assess the risk for neurodevelopmental impairment and facilitate an early intervention in newborns developing seizures. |
| first_indexed | 2024-12-21T13:22:31Z |
| format | Article |
| id | doaj.art-8bb937cf325f4844b7bbc47cdb3f2242 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T13:22:31Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8bb937cf325f4844b7bbc47cdb3f22422022-12-21T19:02:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e7896010.1371/journal.pone.0078960The prognostic value of amplitude-integrated EEG in full-term neonates with seizures.Dandan ZhangHaiyan DingLili LiuXinlin HouGuoyu SunLei LiYunzhe LiuCongle ZhouRuolei GuYuejia LuoNeonatal seizures pose a high risk for adverse outcome in survived infants. While the prognostic value of amplitude-integrated electroencephalogram (aEEG) is well established in neonates with encephalopathy and asphyxia, neonatal seizure studies focusing on the direct correlation between early aEEG measurement and subsequent neurologic outcome are scarce. In this study, the prognostic value of aEEG features was systematically analyzed in 143 full-term neonates to identify prognostic indicators of neurodevelopmental outcome. Neonatal aEEG features of background pattern, cyclicity, and seizure activity, as well as the etiology of neonatal seizures, were significantly associated with neurodevelopmental outcome at one year of age. aEEG background pattern was highly associated with neurologic outcomes (χ² = 116.9), followed by aEEG cyclicity (χ² = 87.2) and seizure etiology (χ² = 79.3). Multiple linear regression showed that the four predictors explained 71.2% of the variation in neurological outcome, with standardized β coefficients of 0.44, 0.24, 0.22, and 0.14 for the predictors of aEEG background pattern, cyclicity, etiology, and aEEG seizure activity, respectively. This clinically applicable scoring system based on etiology and three aEEG indices would allow pediatricians to assess the risk for neurodevelopmental impairment and facilitate an early intervention in newborns developing seizures.http://europepmc.org/articles/PMC3827298?pdf=render |
| spellingShingle | Dandan Zhang Haiyan Ding Lili Liu Xinlin Hou Guoyu Sun Lei Li Yunzhe Liu Congle Zhou Ruolei Gu Yuejia Luo The prognostic value of amplitude-integrated EEG in full-term neonates with seizures. PLoS ONE |
| title | The prognostic value of amplitude-integrated EEG in full-term neonates with seizures. |
| title_full | The prognostic value of amplitude-integrated EEG in full-term neonates with seizures. |
| title_fullStr | The prognostic value of amplitude-integrated EEG in full-term neonates with seizures. |
| title_full_unstemmed | The prognostic value of amplitude-integrated EEG in full-term neonates with seizures. |
| title_short | The prognostic value of amplitude-integrated EEG in full-term neonates with seizures. |
| title_sort | prognostic value of amplitude integrated eeg in full term neonates with seizures |
| url | http://europepmc.org/articles/PMC3827298?pdf=render |
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